公开(公告)号：US12005054B2

公开(公告)日：2024-06-11

申请号：US17320574

申请日：2021-05-14

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Zacharia Cheruvallath ,  Jason Green ,  Ben Johnson ,  Kristin Schleicher ,  Huikai Sun ,  Mingnam Tang

IPC: A61K31/4439 ,  A61K31/40 ,  A61K31/4355 ,  A61K31/438 ,  A61K31/4468 ,  A61K31/4545 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  C07D207/14 ,  C07D211/58 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D491/048

CPC classification number: A61K31/4439 ,  A61K31/40 ,  A61K31/4355 ,  A61K31/438 ,  A61K31/4468 ,  A61K31/4545 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  C07D207/14 ,  C07D211/58 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D491/048

Abstract: Disclosed are compounds of Formula 1,




stereoisomers thereof, and pharmaceutically acceptable salts thereof, wherein L, r, s, R5, R6, R7, R9, R10, R11, R12, X1, X2, X3, X4, X13, and X14 are defined in the specification. This disclosure also relates to materials and methods for preparing compounds of Formula 1, to pharmaceutical compositions which contain them, and to their use for treating diseases, disorders, and conditions associated with SSTR4.

公开(公告)号：US11045457B2

公开(公告)日：2021-06-29

申请号：US16289311

申请日：2019-02-28

Applicant: Takeda Pharmaceutical Company Limited ,  Zacharia Cheruvallath ,  Jason Green ,  Ben Johnson ,  Kristin Schleicher ,  Huikai Sun ,  Mingnam Tang

Inventor： Zacharia Cheruvallath ,  Jason Green ,  Ben Johnson ,  Kristin Schleicher ,  Huikai Sun ,  Mingnam Tang

IPC: C07D207/14 ,  A61K31/4439 ,  A61K31/40 ,  A61K31/4355 ,  A61K31/438 ,  A61K31/4468 ,  A61K31/4545 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  C07D211/58 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D491/048

Abstract: Disclosed are compounds of Formula 1, stereoisomers thereof, and pharmaceutically acceptable salts thereof, wherein L, r, s, R5, R6, R7, R9, R10, R11, R12, X1, X2, X3, X4, X13, and X14 are defined in the specification. This disclosure also relates to materials and methods for preparing compounds of Formula 1, to pharmaceutical compositions which contain them, and to their use for treating diseases, disorders, and conditions associated with SSTR4.

公开(公告)号：US20230021834A1

公开(公告)日：2023-01-26

申请号：US17320574

申请日：2021-05-14

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Zacharia Cheruvallath ,  Jason Green ,  Ben Johnson ,  Kristin Schleicher ,  Huikai Sun ,  Mingnam Tang

IPC: A61K31/4439 ,  A61K31/40 ,  A61K31/4355 ,  A61K31/438 ,  A61K31/4468 ,  A61K31/4545 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  C07D207/14 ,  C07D211/58 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D491/048

Abstract: Disclosed are compounds of Formula 1, stereoisomers thereof, and pharmaceutically acceptable salts thereof, wherein L, r, s, R5, R6, R7, R9, R10, R11, R12, X1, X2, X3, X4, X13, and X14 are defined in the specification. This disclosure also relates to materials and methods for preparing compounds of Formula 1, to pharmaceutical compositions which contain them, and to their use for treating diseases, disorders, and conditions associated with SSTR4.

公开(公告)号：US11426397B2

公开(公告)日：2022-08-30

申请号：US16497967

申请日：2018-03-26

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Jason Green ,  Maria Hopkins ,  Benjamin Jones ,  Andre A. Kiryanov ,  Jon Kuehler ,  Holger Monenschein ,  Sean Murphy ,  Thomas Nixey ,  Huikai Sun

IPC: C07D417/12 ,  A61K31/4545 ,  A61K31/198 ,  A61K31/451 ,  A61K31/4525 ,  A61K31/4535 ,  A61K31/454 ,  A61K31/496 ,  A61K31/501 ,  A61K31/506 ,  A61K31/519 ,  A61K31/5365 ,  A61K31/553 ,  C07D211/52 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D487/04 ,  C07D498/04

Abstract: Disclosed are compounds of Formula 1 and pharmaceutically acceptable salts thereof, wherein L, R4, R5, R8, R10, R11, X1, X2, X3, X9, X12, and Z are defined in the specification. This disclosure also relates to materials and methods for preparing compounds of Formula 1, to pharmaceutical compositions which contain them, and to their use for treating diseases, disorders, and conditions associated with GPR6.

公开(公告)号：US20200061041A1

公开(公告)日：2020-02-27

申请号：US16289311

申请日：2019-02-28

Applicant: Zacharia Cheruvallath ,  Jason Green ,  Ben Johnson ,  Kristin Schleicher ,  Huikai Sun ,  Mingnam Tang ,  Takeda Pharmaceutical Company Limited

Inventor： Zacharia Cheruvallath ,  Jason Green ,  Ben Johnson ,  Kristin Schleicher ,  Huikai Sun ,  Mingnam Tang

IPC: A61K31/4439 ,  C07D401/12 ,  A61K31/4545 ,  C07D403/12 ,  A61K31/506 ,  C07D401/14 ,  A61K31/40 ,  C07D207/14 ,  C07D211/58 ,  A61K31/4468 ,  A61K31/501 ,  A61K31/497 ,  A61K31/4355 ,  C07D491/048 ,  A61K31/438

Abstract: Disclosed are compounds of Formula 1, stereoisomers thereof, and pharmaceutically acceptable salts thereof, wherein L, r, s, R5, R6, R7, R9, R10, R11, R12, X1, X2, X3, X4, X13, and X14 are defined in the specification. This disclosure also relates to materials and methods for preparing compounds of Formula 1, to pharmaceutical compositions which contain them, and to their use for treating diseases, disorders, and conditions associated with SSTR4.

公开(公告)号：US20200375969A1

公开(公告)日：2020-12-03

申请号：US16497967

申请日：2018-03-26

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Jason Green ,  Maria Hopkins ,  Benjamin Jones ,  Andre A. Kiryanov ,  Jon Kuehler ,  Holger Monenschein ,  Sean Murphy ,  Thomas Nixey ,  Huikai Sun

IPC: A61K31/4545 ,  A61K31/198 ,  A61K31/454 ,  A61K31/451 ,  A61K31/506 ,  A61K31/4525 ,  A61K31/496 ,  A61K31/553 ,  A61K31/4535 ,  A61K31/519 ,  A61K31/501 ,  A61K31/5365 ,  C07D401/12 ,  C07D211/52 ,  C07D401/14 ,  C07D405/12 ,  C07D498/04 ,  C07D413/12 ,  C07D409/12 ,  C07D487/04 ,  C07D417/12

Abstract: Disclosed are compounds of Formula 1 and pharmaceutically acceptable salts thereof, wherein L, R4, R5, R8, R10, R11, X1, X2, X3, X9, X12, and Z are defined in the specification. This disclosure also relates to materials and methods for preparing compounds of Formula 1, to pharmaceutical compositions which contain them, and to their use for treating diseases, disorders, and conditions associated with GPR6.