公开(公告)号：US10668260B2

公开(公告)日：2020-06-02

申请号：US14774385

申请日：2014-03-11

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Yoshihiro Omachi ,  Yasuhiro Hiraishi ,  Masami Kusaka ,  Shigehiro Asano ,  Masao Nagao

IPC: A61M37/00 ,  A61K9/00 ,  A61K9/70 ,  B29C45/00 ,  B29C45/16 ,  B29K101/12 ,  B29L9/00 ,  B29L31/00

Abstract: The present invention provides a microneedle patch which can solve the problem that microneedle production is difficult and requires high accuracy, the problem that time and mental burdens on a health professional and a patient are large, and the problem caused by compounding a plurality of drugs. The microneedle patch comprises a large number of drug-carrying microprojections 4 erected on one support sheet, each microprojection 4 having a drug layer 5 soluble in vivo at its top part and having an intermediate layer 6 under the drug layer 5, the intermediate layer 6 containing a polymeric substance for adhesion of the drug layer 5 to the support sheet, the drug layer 5 at the top part of the microprojection 4 containing a single drug, the microprojections 4 holding difference types of drugs being arranged together on the support sheet 2.

公开(公告)号：US20130261156A1

公开(公告)日：2013-10-03

申请号：US13905090

申请日：2013-05-29

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Yasuhiro Hiraishi ,  Muneo Nonomura

IPC: A61K47/12 ,  A61K47/10 ,  A61K47/02

CPC classification number: A61K47/12 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2853 ,  A61K9/2866 ,  A61K31/4427 ,  A61K47/02 ,  A61K47/10

Abstract: The present invention provides a pharmaceutical composition or a solid preparation containing a stabilized pharmaceutically active ingredient and a stabilizing method thereof.According to the present invention, a pharmaceutical composition can be stabilized by containing a nonpeptidic pharmaceutically active ingredient having a primary or secondary amino group, an excipient and an acidic compound. In addition, a solid preparation containing a pharmaceutically active ingredient, titanium oxide, a plasticizer and a chain organic acid can enhance the stability of the pharmaceutically active ingredient during light irradiation.

Abstract translation: 本发明提供含有稳定的药物活性成分的药物组合物或固体制剂及其稳定化方法。 根据本发明，可以通过含有具有伯氨基或仲氨基的非肽类药物活性成分，赋形剂和酸性化合物来稳定药物组合物。 此外，含有药物活性成分，氧化钛，增塑剂和链状有机酸的固体制剂可以在光照射期间增强药物活性成分的稳定性。