公开(公告)号：US11465978B2

公开(公告)日：2022-10-11

申请号：US15021592

申请日：2014-09-11

申请人： THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND ,  DUQUESNE UNIVERSITY OF THE HOLY GHOST

发明人： Suravi Chakrabarty ,  Patrick T. Flaherty ,  Darlene Monlish ,  Jane E. Cavanaugh ,  Matthew E. Burow ,  Steven Elliott ,  Van T. Hoang

IPC分类号： C07D295/192 ,  C07D295/16 ,  C07C229/58 ,  C07C237/30 ,  C07C237/32 ,  C07C237/34 ,  C07C237/36

摘要： Disclosed are anthranilic amide derivatives having the formula. Compositions are disclosed that include the anthranilic amide derivatives and the use of the anthranilic amide derivatives for the manufacture of a medicament. Further disclosed are methods of inhibiting or treating cancer, inhibiting or reversing an epithelial to mesenchymal cellular transition, and/or inhibiting MEK1/2 and/or MEK 5 enzymatic activity in a subject by administering to the subject an effective amount of a disclosed anthranilic amide derivative.

公开(公告)号：US10654792B2

公开(公告)日：2020-05-19

申请号：US15383635

申请日：2016-12-19

申请人： DUQUESNE UNIVERSITY OF THE HOLY GHOST

发明人： Suravi Chakrabarty ,  Darlene Monlish ,  Patrick Flaherty ,  Jane E. Cavanaugh ,  Sneha Potdar

IPC分类号： C07C227/10 ,  C07C229/58

摘要： The invention generally relates to compounds having structure I: wherein x represents alkyl, aryl or het-aryl, each of y independently represents hydrogen or halogen and z represents hydrogen or alkyl. Further, said compounds are inhibitors of MEK 1, 2 and 5. Furthermore, the invention includes methods of making said compounds, compositions including said compounds and uses for inhibiting MEK 1, 2 and 5.

公开(公告)号：US09556112B2

公开(公告)日：2017-01-31

申请号：US14081426

申请日：2013-11-15

申请人： DUQUESNE UNIVERSITY OF THE HOLY GHOST

发明人： Suravi Chakrabarty ,  Darlene Monlish ,  Patrick Flaherty ,  Jane E. Cavanaugh ,  Sneha Potdar

IPC分类号： C07C229/58

CPC分类号： C07C227/10 ,  C07C229/58

摘要： The invention generally relates to compounds having structure I: wherein x represents alkyl, aryl or het-aryl, each of y independently represents hydrogen or halogen and z represents hydrogen or alkyl. Further, said compounds are inhibitors of MEK 1, 2 and 5. Furthermore, the invention includes methods of making said compounds, compositions including said compounds and uses for inhibiting MEK 1, 2 and 5.

摘要翻译： 本发明一般涉及具有结构I的化合物：其中x代表烷基，芳基或苯基 - 芳基，y各自独立地表示氢或卤素，z代表氢或烷基。 此外，所述化合物是MEK 1,2和5的抑制剂。此外，本发明包括制备所述化合物，包含所述化合物的组合物和用于抑制MEK 1,2和5的方法。