公开(公告)号：US20240101667A1

公开(公告)日：2024-03-28

申请号：US18255745

申请日：2021-12-02

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Chengcheng ZHANG ,  Guojin WU ,  Jaehyup KIM ,  Heyu CHEN ,  Mi DENG ,  Zhiqiang AN ,  Ningyan ZHANG ,  Ryan HUANG

IPC: C07K16/28 ,  A61P35/02 ,  G01N33/574 ,  G01N33/577

CPC classification number: C07K16/2803 ,  A61P35/02 ,  G01N33/574 ,  G01N33/577 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/76 ,  C07K2317/92

Abstract: Provided herein are methods and compositions for the identification of modulators of LILRB3 activation. Also provided herein are methods of treating cancer comprising the administration of an inhibitor LILRB3 activation. Also provided are methods of treating autoimmune disease or inhibiting the onset of transplant rejection or treating an inflammatory disorder comprising administering an agonist of LILRB3 activation to a subject.