公开(公告)号：US20210179687A1

公开(公告)日：2021-06-17

申请号：US16762273

申请日：2018-11-06

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Chengcheng ZHANG ,  Samuel JOHN ,  Heyu CHEN ,  Mi DENG ,  Xun GUI ,  Ningyan ZHANG ,  Zhiqiang AN

IPC: C07K14/705 ,  A61K45/06 ,  A61P35/02 ,  C12N5/0783

Abstract: The present disclosure provides methods and compositions for immunotherapy employing a modified T cell or NK cell comprising a chimeric LILRB4 antigen receptor (CAR) that can be administered to patients for disease (e.g., cancer) treatment.

公开(公告)号：US20230068663A1

公开(公告)日：2023-03-02

申请号：US17759800

申请日：2021-01-28

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM ,  IMMUNE-ONC THERAPEUTICS, INC.

Inventor： Zhiqiang AN ,  Ningyan ZHANG ,  Zhiqiang KU ,  Chengcheng ZHANG ,  Xiaoye XU ,  Heyu CHEN ,  JingJing XIE ,  Maria Jose COSTA ,  An SONG ,  X. Charlene LIAO

IPC: C07K16/28 ,  A61K45/06 ,  A61K47/68 ,  A61P35/02 ,  A61K39/395 ,  G01N33/574

Abstract: Provided herein are antibodies binding to LILRB2 and the uses of the antibodies in detecting and treating cancer and autoimmune diseases.

公开(公告)号：US20240101667A1

公开(公告)日：2024-03-28

申请号：US18255745

申请日：2021-12-02

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Chengcheng ZHANG ,  Guojin WU ,  Jaehyup KIM ,  Heyu CHEN ,  Mi DENG ,  Zhiqiang AN ,  Ningyan ZHANG ,  Ryan HUANG

IPC: C07K16/28 ,  A61P35/02 ,  G01N33/574 ,  G01N33/577

CPC classification number: C07K16/2803 ,  A61P35/02 ,  G01N33/574 ,  G01N33/577 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/76 ,  C07K2317/92

Abstract: Provided herein are methods and compositions for the identification of modulators of LILRB3 activation. Also provided herein are methods of treating cancer comprising the administration of an inhibitor LILRB3 activation. Also provided are methods of treating autoimmune disease or inhibiting the onset of transplant rejection or treating an inflammatory disorder comprising administering an agonist of LILRB3 activation to a subject.

公开(公告)号：US20230235055A1

公开(公告)日：2023-07-27

申请号：US18007185

申请日：2021-07-26

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Zhiqiang AN ,  Chengcheng ZHANG ,  Ningyan ZHANG ,  Yuanzhi CHEN ,  Heyu CHEN

IPC: C07K16/28 ,  A61K45/06 ,  G01N33/574 ,  A61K39/395 ,  A61P35/00

CPC classification number: C07K16/2803 ,  A61K45/06 ,  G01N33/57484 ,  A61K39/3955 ,  A61P35/00 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/73 ,  A61K2039/505

Abstract: Provided herein are antibodies binding to LILRB1 and the uses of the antibodies in detecting and treating cancer and autoimmune diseases.