公开(公告)号：US12116597B2

公开(公告)日：2024-10-15

申请号：US17824621

申请日：2022-05-25

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Dong H. Kim ,  Yanning Rui ,  Zhen Xu ,  John Hagan

IPC: C12N5/071 ,  A61B17/12 ,  A61K31/351 ,  A61K31/37 ,  A61K31/404 ,  A61K31/4706 ,  A61K31/496 ,  A61K31/5025 ,  A61K31/506 ,  A61K31/517 ,  A61K31/52 ,  A61K31/5377 ,  A61K31/55 ,  A61K38/10 ,  A61P9/00 ,  A61P9/10 ,  C07K14/495

CPC classification number: C12N5/069 ,  A61B17/1215 ,  A61K31/351 ,  A61K31/37 ,  A61K31/404 ,  A61K31/4706 ,  A61K31/496 ,  A61K31/5025 ,  A61K31/506 ,  A61K31/517 ,  A61K31/52 ,  A61K31/5377 ,  A61K31/55 ,  A61K38/10 ,  A61P9/00 ,  A61P9/10 ,  C07K14/495 ,  C12N2510/02

Abstract: Disclosed here are uses of autophagy inhibitors for treating a subject at risk of suffering from an aneurysm. The present disclosure demonstrates that autophagy plays a role in THSD1-mediated focal adhesion stability and aneurysm formation and characterizes molecular targets for therapeutic intervention.

公开(公告)号：US20230210858A1

公开(公告)日：2023-07-06

申请号：US17824631

申请日：2022-05-25

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Dong H. Kim ,  Zhen Xu ,  Yanning Rui ,  John Hagan

IPC: A61K31/5377 ,  A61K31/404 ,  A61K31/517 ,  A61K31/496 ,  A61K31/506 ,  A61K31/5025 ,  A61P9/00

CPC classification number: A61K31/5377 ,  A61K31/404 ,  A61K31/517 ,  A61K31/496 ,  A61K31/506 ,  A61K31/5025 ,  A61P9/00

Abstract: Disclosed here are uses of anti-podosome therapies for treating a subject at risk of suffering from an aneurysm. The present disclosure demonstrates that endothelial podosomes plays a role in THSD1-mediated focal adhesion stability and aneurysm formation and characterizes molecular targets for therapeutic intervention.

公开(公告)号：US20230270715A1

公开(公告)日：2023-08-31

申请号：US17824621

申请日：2022-05-25

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Dong H. Kim ,  Yanning Rui ,  Zhen Xu ,  John Hagan

IPC: A61K31/37 ,  A61K31/4706 ,  A61K31/55 ,  A61K31/52 ,  A61K31/351 ,  A61K38/10 ,  A61P9/10

CPC classification number: A61K31/37 ,  A61K31/52 ,  A61K31/55 ,  A61K31/351 ,  A61K31/4706 ,  A61K38/10 ,  A61P9/10

Abstract: Disclosed here are uses of autophagy inhibitors for treating a subject at risk of suffering from an aneurysm. The present disclosure demonstrates that autophagy plays a role in THSD1-mediated focal adhesion stability and aneurysm formation and characterizes molecular targets for therapeutic intervention.

公开(公告)号：US20230212522A1

公开(公告)日：2023-07-06

申请号：US17824612

申请日：2022-05-25

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Dong H. Kim ,  Yuanqing Yan ,  Yanning Rui ,  Zhen Xu ,  John Hagan

IPC: C12N5/071

CPC classification number: C12N5/069 ,  C12N2510/02

Abstract: The disclosure describes global transcriptome profiling in human vascular endothelial cells upon THSD1 knockdown and identification from these studies of specific genes and pathways that are THSD1. The analysis highlights a role for THSD1 in regulating endothelial to mesenchymal transition and other pathways. The analysis also demonstrates that endothelial cell injury is the first event of an intracranial aneurysm. The disclosure provides novel cell lines and reagents used for better understanding the molecular mechanism of THSD1 biology.

公开(公告)号：US20230212246A1

公开(公告)日：2023-07-06

申请号：US17824641

申请日：2022-05-25

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Dong H. Kim ,  Zhen Xu ,  Yanning Rui ,  John Hagan

IPC: C07K14/495 ,  A61B17/12

CPC classification number: C07K14/495 ,  A61B17/1215

Abstract: Disclosed here are metal coils conjugated to TGF-beta ligand(s) or TGF-beta activator(s) to improve the outcome of existing surgical treatments on intracranial aneurysm patients and methods for using the same.