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公开(公告)号：US20230212522A1
公开(公告)日：2023-07-06
申请号：US17824612
申请日：2022-05-25
Inventor： Dong H. Kim , Yuanqing Yan , Yanning Rui , Zhen Xu , John Hagan
IPC: C12N5/071
CPC classification number: C12N5/069 , C12N2510/02
Abstract: The disclosure describes global transcriptome profiling in human vascular endothelial cells upon THSD1 knockdown and identification from these studies of specific genes and pathways that are THSD1. The analysis highlights a role for THSD1 in regulating endothelial to mesenchymal transition and other pathways. The analysis also demonstrates that endothelial cell injury is the first event of an intracranial aneurysm. The disclosure provides novel cell lines and reagents used for better understanding the molecular mechanism of THSD1 biology.
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