公开(公告)号：US20220304766A1

公开(公告)日：2022-09-29

申请号：US17703238

申请日：2022-03-24

Applicant: UROGEN PHARMA LTD. ,  The Regents of the University of California

Inventor： Ralph V. CLAYMAN ,  Pengbo Jiang ,  Mark Schoenberg ,  Omer Tsipori

IPC: A61B90/00 ,  A61B18/26 ,  A61L24/00 ,  A61L24/08

Abstract: Provided herein are methods for treating nephrolithiasis and protecting the urothelium and inner lining of the kidney from thermal damage during lithotripsy by use of a thermosensitive bio-adhesive hydrogel. The described method dramatically improved the efficiency and effectiveness of stone clearance compared to conventional techniques while providing protection to the urothelium from potentially damaging temperature spikes.

公开(公告)号：US20230364419A1

公开(公告)日：2023-11-16

申请号：US18317724

申请日：2023-05-15

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Ralph V. Clayman ,  Jamie Landman ,  Seyed Hossein Hosseini Sharifi ,  Pengbo Jiang

IPC: A61N1/30

CPC classification number: A61N1/306

Abstract: A medical urology device for drug delivery to the lining and deeper tissues of the ureter and kidney. The present invention features an electromotive drug administration (EMDA) catheter device for deploying a fluid to deep tissues of a patient. The device includes a catheter body with fenestrations along its distal length. The device may further comprise a multiport component for allowing access to the catheter body. The device may further comprise a conductive wire removably disposed through the multiport component within the catheter body. Fluid may be directed through the multiport component and the plurality of fenestrations to the body structure of the patient. Electrical stimulation directed through the conductive wire enhances the penetration of medications with the same polarity to electrical stimulation into a body structure of the patient to allow the fluid to penetrate deep tissues.

公开(公告)号：US11576744B2

公开(公告)日：2023-02-14

申请号：US17703238

申请日：2022-03-24

Applicant: UROGEN PHARMA LTD. ,  The Regents of the University of California

Inventor： Ralph V. Clayman ,  Pengbo Jiang ,  Mark Schoenberg ,  Omer Tsipori

IPC: A61B90/00 ,  A61B18/26 ,  A61L24/00 ,  A61L24/08 ,  A61K31/722 ,  A61B17/22

Abstract: Provided herein are methods for treating nephrolithiasis and protecting the urothelium and inner lining of the kidney from thermal damage during lithotripsy by use of a thermosensitive bio-adhesive hydrogel. The described method dramatically improved the efficiency and effectiveness of stone clearance compared to conventional techniques while providing protection to the urothelium from potentially damaging temperature spikes.

公开(公告)号：US20220265350A1

公开(公告)日：2022-08-25

申请号：US17738758

申请日：2022-05-06

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Ralph V. Clayman ,  Kamaljot S. Kaler ,  Andrew Emon Heidari ,  Roshan M. Patel ,  Jamie Landman ,  Pengbo Jiang

IPC: A61B18/26 ,  A61B1/273 ,  A61B1/00 ,  A61B1/307 ,  A61B1/01

Abstract: The present technology relates to ureteroscopy, laser ablation of ureteral and renal stone, capture and removal of stone fragments. In one embodiment, the device includes an optical instrument operably connected to a large vacuum channel that is about 1.5 mm to about 8.0 mm in width. In another embodiment, the device includes two single-time use disposable or potentially reusable units, such as a large vacuum endoscope removal tip and a wireless and modular battery-powered handpiece.