公开(公告)号：US20180311468A1

公开(公告)日：2018-11-01

申请号：US15963851

申请日：2018-04-26

Applicant: The Regents of the University of California

Inventor： Ralph V. Clayman ,  Kamaljot S. Kaler ,  Jaime Landman ,  Michael J. Klopfer ,  Guann-Pyng Li

IPC: A61M25/01 ,  A61M25/06

Abstract: Provided herein is a load sensing device. In one embodiment, the device comprises a load cell adapted to receive a force, an input/output interface, and an adjustable attachment mechanism adapted to reversibly attach a surgical device. In another embodiment, the load cell detects the amount of force applied during the deployment of the surgical device in a patient and outputs a force value representative thereof via the input/output interface. Also provided herein are methods of making and using load sensing devices.

公开(公告)号：US20190076209A1

公开(公告)日：2019-03-14

申请号：US16127996

申请日：2018-09-11

Applicant: The Regents of The University of California

Inventor： Ralph V. Clayman ,  Kam Kaler ,  Michael Klopfer

IPC: A61B90/00 ,  A61B1/00 ,  A61B1/307

Abstract: The invention relates to medical devices and methods of use thereof, such as for example, ureteroscopy. In one embodiment, the device is a safety ureteral access sheath and interventional catheter insertion with a force meter and a force disengagement mechanism. In another embodiment, the invention provides a method of examination or treatment for a condition in a subject, comprising providing a device comprising a ureteral access sheath (UAS) operably linked to a force meter and a force disengagement mechanism, and using the device to examine or treat the subject.

公开(公告)号：US20230190078A1

公开(公告)日：2023-06-22

申请号：US18169646

申请日：2023-02-15

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Ralph V. Clayman ,  Jamie Landman ,  Zachary Tano ,  Antonio R. H. Gorgen ,  Andrei Cumpanas

IPC: A61B1/00 ,  A61B1/015 ,  A61B1/018 ,  A61B1/05 ,  A61B1/06 ,  A61B10/04

CPC classification number: A61B1/00094 ,  A61B1/015 ,  A61B1/018 ,  A61B1/051 ,  A61B1/0676 ,  A61B1/0684 ,  A61B10/04

Abstract: The present technology relates to endoscope devices and methods of use for said endoscope devices. In one embodiment, the device comprises a semicircular aspiration channel with a blocking bar disposed at an outlet of the semicircular aspiration channel to prevent clogging of said channel. The endoscope devices of the present invention may further comprise a plurality of working channels, an image sensor, and a light source. In addition, for work within the ureter, a force sensor is incorporated to ensure safe passage of the largest flexible ureteroscope.

公开(公告)号：US20220126066A1

公开(公告)日：2022-04-28

申请号：US17570776

申请日：2022-01-07

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Ralph V. Clayman ,  Kamaljot S. Kaler ,  Jamie Landman ,  Michael John Klopfer ,  Guann-Pyng Li

IPC: A61M25/06 ,  A61B90/00 ,  A61M25/01 ,  A61M25/00

Abstract: Various embodiments herein comprise a handheld load sensing device. In one embodiment, the device comprises a force sensor (e.g., a mechanical spring or an electromechanical load cell) adapted to receive a force, an input/output interface, and an adjustable attachment mechanism adapted to reversibly attach a surgical device. In another embodiment, the force sensor detects the amount of force applied during the deployment of the surgical device in a patient and outputs a force value representative thereof via the input/output interface. Also provided herein are methods of making and using load sensing devices.

公开(公告)号：US20230364419A1

公开(公告)日：2023-11-16

申请号：US18317724

申请日：2023-05-15

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Ralph V. Clayman ,  Jamie Landman ,  Seyed Hossein Hosseini Sharifi ,  Pengbo Jiang

IPC: A61N1/30

CPC classification number: A61N1/306

Abstract: A medical urology device for drug delivery to the lining and deeper tissues of the ureter and kidney. The present invention features an electromotive drug administration (EMDA) catheter device for deploying a fluid to deep tissues of a patient. The device includes a catheter body with fenestrations along its distal length. The device may further comprise a multiport component for allowing access to the catheter body. The device may further comprise a conductive wire removably disposed through the multiport component within the catheter body. Fluid may be directed through the multiport component and the plurality of fenestrations to the body structure of the patient. Electrical stimulation directed through the conductive wire enhances the penetration of medications with the same polarity to electrical stimulation into a body structure of the patient to allow the fluid to penetrate deep tissues.

公开(公告)号：US11576744B2

公开(公告)日：2023-02-14

申请号：US17703238

申请日：2022-03-24

Applicant: UROGEN PHARMA LTD. ,  The Regents of the University of California

Inventor： Ralph V. Clayman ,  Pengbo Jiang ,  Mark Schoenberg ,  Omer Tsipori

IPC: A61B90/00 ,  A61B18/26 ,  A61L24/00 ,  A61L24/08 ,  A61K31/722 ,  A61B17/22

Abstract: Provided herein are methods for treating nephrolithiasis and protecting the urothelium and inner lining of the kidney from thermal damage during lithotripsy by use of a thermosensitive bio-adhesive hydrogel. The described method dramatically improved the efficiency and effectiveness of stone clearance compared to conventional techniques while providing protection to the urothelium from potentially damaging temperature spikes.

公开(公告)号：US20220265350A1

公开(公告)日：2022-08-25

申请号：US17738758

申请日：2022-05-06

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Ralph V. Clayman ,  Kamaljot S. Kaler ,  Andrew Emon Heidari ,  Roshan M. Patel ,  Jamie Landman ,  Pengbo Jiang

IPC: A61B18/26 ,  A61B1/273 ,  A61B1/00 ,  A61B1/307 ,  A61B1/01

Abstract: The present technology relates to ureteroscopy, laser ablation of ureteral and renal stone, capture and removal of stone fragments. In one embodiment, the device includes an optical instrument operably connected to a large vacuum channel that is about 1.5 mm to about 8.0 mm in width. In another embodiment, the device includes two single-time use disposable or potentially reusable units, such as a large vacuum endoscope removal tip and a wireless and modular battery-powered handpiece.

公开(公告)号：US20190274698A1

公开(公告)日：2019-09-12

申请号：US16253015

申请日：2019-01-21

Applicant: The Regents of the University of California

Inventor： Kamaijot Kaler ,  Daniel Meller ,  Roshan M. Patel ,  Ralph V. Clayman

IPC: A61B17/221

Abstract: Provided herein are devices related to the removal of uroliths, including kidney, ureteral and/or bladder stones. In one embodiment, the device comprises a mesh or sponge that is removably connected to a catheter, adapted for the removal of urolith fragments of the size 2 mm or less. In one embodiment, the device includes a catheter that is either solid or hollow, the latter for the irrigation of various types of fluid (either standard irrigation fluid (e.g. saline or water) or a material (e.g. blood, fibrin glue, etc.) that would form a clot like substance within the interstices of the device thereby increasing its ability to entrap fragments within the interstices of the basket or nearby.