公开(公告)号：US20220057328A1

公开(公告)日：2022-02-24

申请号：US17516490

申请日：2021-11-01

Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE ,  UNIVERSITY HEALTH NETWORK

Inventor： Keith D. Paulsen ,  David W. Roberts ,  Dennis Wirth ,  Brian C. Wilson ,  Mira Sibai

IPC: G01N21/64 ,  G01B11/22 ,  G01N21/47 ,  G01N33/483

Abstract: A method and device for determining the depth and fluorophore concentration of a fluorophore concentration below the surface of an optically absorbing and scattering medium suitable for use in fluorescence-based surgical guidance such as in tumor resection is described. Long-wavelength stimulus light us used to obtain deep tissue penetration. Recovery of depth is performed by fitting measured modulation amplitudes for each spatial frequency to precomputed modulation amplitudes in a table of modulation amplitudes indexed by optical parameters and depth.

公开(公告)号：US11662315B2

公开(公告)日：2023-05-30

申请号：US17516490

申请日：2021-11-01

Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE ,  UNIVERSITY HEALTH NETWORK

Inventor： Keith D. Paulsen ,  David W. Roberts ,  Dennis Wirth ,  Brian C. Wilson ,  Mira Sibai

IPC: G01B11/22 ,  G01N21/64 ,  G01N21/47 ,  G01N33/483

CPC classification number: G01N21/6456 ,  G01B11/22 ,  G01N21/4795 ,  G01N33/4833 ,  G01N2201/062

Abstract: A method and device for determining the depth and fluorophore concentration of a fluorophore concentration below the surface of an optically absorbing and scattering medium suitable for use in fluorescence-based surgical guidance such as in tumor resection is described. Long-wavelength stimulus light us used to obtain deep tissue penetration. Recovery of depth is performed by fitting measured modulation amplitudes for each spatial frequency to precomputed modulation amplitudes in a table of modulation amplitudes indexed by optical parameters and depth.

公开(公告)号：US20210239617A1

公开(公告)日：2021-08-05

申请号：US17050745

申请日：2019-04-26

Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE ,  UNIVERSITY HEALTH NETWORK

Inventor： Keith D. Paulsen ,  David W. Roberts ,  Dennis Wirth ,  Brian C. Wilson ,  Mira Sibai

IPC: G01N21/64 ,  G01N33/483 ,  G01B11/22 ,  G01N21/47

Abstract: A method and device for determining the depth and fluorophore concentration of a fluorophore concentration below the surface of an optically absorbing and scattering medium suitable for use in fluorescence-based surgical guidance such as in tumor resection is described. Long-wavelength stimulus light us used to obtain deep tissue penetration. Recovery of depth is performed by fitting measured modulation amplitudes for each spatial frequency to precomputed modulation amplitudes in a table of modulation amplitudes indexed by optical parameters and depth.

公开(公告)号：US11162900B2

公开(公告)日：2021-11-02

申请号：US17050745

申请日：2019-04-26

Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE ,  UNIVERSITY HEALTH NETWORK

Inventor： Keith D. Paulsen ,  David W. Roberts ,  Dennis Wirth ,  Brian C. Wilson ,  Mira Sibai

IPC: G01N21/64 ,  G01N33/483 ,  G01N21/47 ,  G01B11/22

Abstract: A method and device for determining the depth and fluorophore concentration of a fluorophore concentration below the surface of an optically absorbing and scattering medium suitable for use in fluorescence-based surgical guidance such as in tumor resection is described. Long-wavelength stimulus light us used to obtain deep tissue penetration. Recovery of depth is performed by fitting measured modulation amplitudes for each spatial frequency to precomputed modulation amplitudes in a table of modulation amplitudes indexed by optical parameters and depth.

公开(公告)号：US11977027B2

公开(公告)日：2024-05-07

申请号：US18202823

申请日：2023-05-26

Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE ,  UNIVERSITY HEALTH NETWORK

Inventor： Keith D. Paulsen ,  David W. Roberts ,  Dennis Wirth ,  Brian C. Wilson ,  Mira Sibai

IPC: G01B11/22 ,  G01N21/47 ,  G01N21/64 ,  G01N33/483

CPC classification number: G01N21/6456 ,  G01B11/22 ,  G01N21/4795 ,  G01N33/4833 ,  G01N2201/062

Abstract: A method and device for determining the depth and fluorophore concentration of a fluorophore concentration below the surface of an optically absorbing and scattering medium suitable for use in fluorescence-based surgical guidance such as in tumor resection is described. Long-wavelength stimulus light us used to obtain deep tissue penetration. Recovery of depth is performed by fitting measured modulation amplitudes for each spatial frequency to precomputed modulation amplitudes in a table of modulation amplitudes indexed by optical parameters and depth.

公开(公告)号：US20230324301A1

公开(公告)日：2023-10-12

申请号：US18202823

申请日：2023-05-26

Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE ,  UNIVERSITY HEALTH NETWORK

Inventor： Keith D. Paulsen ,  David W. Roberts ,  Dennis Wirth ,  Brian C. Wilson ,  Mira Sibai

IPC: G01N21/64 ,  G01N21/47 ,  G01B11/22 ,  G01N33/483

CPC classification number: G01N21/6456 ,  G01B11/22 ,  G01N21/4795 ,  G01N33/4833 ,  G01N2201/062

Abstract: A method and device for determining the depth and fluorophore concentration of a fluorophore concentration below the surface of an optically absorbing and scattering medium suitable for use in fluorescence-based surgical guidance such as in tumor resection is described. Long-wavelength stimulus light us used to obtain deep tissue penetration. Recovery of depth is performed by fitting measured modulation amplitudes for each spatial frequency to precomputed modulation amplitudes in a table of modulation amplitudes indexed by optical parameters and depth.

公开(公告)号：US20250160649A1

公开(公告)日：2025-05-22

申请号：US19025446

申请日：2025-01-16

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Ralph S. DaCosta ,  Brian C. Wilson ,  Kai Zhang

IPC: A61B5/00 ,  A61B5/01 ,  A61B10/00 ,  G01N21/64

Abstract: A device for fluorescence-based imaging and monitoring of a target is provided. The device includes a light source emitting light for illuminating the target, the emitted light including at least one wavelength or wavelength band causing at least one biomarker associated with the target to fluoresce, and a light detector for detecting the fluorescence.

公开(公告)号：US20250152010A1

公开(公告)日：2025-05-15

申请号：US19025440

申请日：2025-01-16

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Ralph S. DaCosta ,  Brian C. Wilson ,  Kai Zhang

IPC: A61B5/00 ,  A61B5/01 ,  A61B10/00 ,  G01N21/64

Abstract: A device for fluorescence-based imaging and monitoring of a target is provided. The device includes a light source emitting light for illuminating the target, the emitted light including at least one wavelength or wavelength band causing at least one biomarker associated with the target to fluoresce, and a light detector for detecting the fluorescence.

公开(公告)号：US12251191B2

公开(公告)日：2025-03-18

申请号：US17856487

申请日：2022-07-01

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Ralph Sebastian Dacosta ,  Brian C. Wilson ,  Kai Zhang

IPC: A61B5/00 ,  A61B5/01 ,  A61B10/00 ,  G01N21/64

Abstract: A system for outputting a representation of a wound in tissue comprises a housing configured to removably receive at least a portion of a wireless communication device. At least one light source coupled to the housing is configured to emit excitation light to illuminate a target which includes at least a portion of the wound. A power supply contained in the housing is configured to provide power to the light source. A non-transitory computer-readable medium stores a program executable to cause the performance of operations comprising detecting signals responsive to illumination of the target, outputting the representation of the target based thereon, storing data relative to one or more target surface parameter based on the detected signals, and displaying the representation. The signals correspond to at least one of endogenous or exogeneous fluorescence, absorbance, and reflectance from at least one biological component in and/or on the target.

公开(公告)号：US20240366090A1

公开(公告)日：2024-11-07

申请号：US18662750

申请日：2024-05-13

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Ralph S. DaCosta ,  Brian C. Wilson ,  Kai Zhang

IPC: A61B5/00 ,  A61B5/01 ,  A61B10/00 ,  G01N21/64

Abstract: A portable imaging system for visualizing bacteria in a wound in real time includes an excitation light source configured to emit violet and/or blue excitation light to illuminate a wound and cause at least one biomarker associated with the wound to fluoresce and a camera configured to detect fluorescence emitted by the at least one biomarker associated with the wound in response to illumination of the wound with the excitation light. A portable frame is configured to support the camera and the excitation light source for hands-free operation and to position the camera and the excitation light source relative to the wound. The system also includes a power source for the excitation light source.