公开(公告)号：US20240361226A1

公开(公告)日：2024-10-31

申请号：US18765836

申请日：2024-07-08

Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATION

Inventor： Nathan SWAMI ,  Walter VARHUE ,  Vahid FARMEHINI

IPC: G01N15/1031 ,  B01L3/00 ,  G01N15/01 ,  G01N33/483 ,  G01R27/16

CPC classification number: G01N15/1031 ,  B01L3/502715 ,  B01L3/502761 ,  G01N33/4833 ,  G01R27/16 ,  B01L2200/0647 ,  B01L2300/0627 ,  G01N15/01

Abstract: An exemplary method and system is disclosed that facilitate the integration of on-chip impedance sensors and measurement circuitries, e.g., in characterizing internal microfluidic structures and/or in cell or particle cytometry, for quantifying the impedance/frequency response of microfluidic device under the same, or similar, conditions used for particle manipulation. In some embodiments, the exemplary method and system employs a circuit configured for automated determination and quantification of parasitic voltage drops during AC electrokinetic particle manipulation, without the need to use valuable biological samples or model particles. The determined impedance response can be used to assess efficacy of the microfluidic device geometry as well as to provide control signals to inform downstream cell separation decisions.

公开(公告)号：US20240359187A1

公开(公告)日：2024-10-31

申请号：US18673451

申请日：2024-05-24

Applicant: Faxitron Bioptics, LLC

Inventor： Ciaran Purdy ,  Donogh O'Driscoll

IPC: B01L9/00 ,  A61B10/00 ,  G01N33/483

CPC classification number: B01L9/52 ,  A61B10/0096 ,  G01N33/4833 ,  B01L2300/0609 ,  B01L2300/0809 ,  B01L2300/123 ,  G01N2223/307 ,  G01N2223/6126

Abstract: A specimen holding and positioning apparatus operable to substantially non-movably maintain a specimen (e.g., an excised tissue specimen) in a fixed or stable orientation with respect to the apparatus during imaging operations (e.g., x-ray imaging), transport (e.g., from a surgery room to a pathologist's laboratory), and the like for use in facilitating accurate detection and diagnosis of cancers and/or other abnormalities of the specimen.

公开(公告)号：US20240352407A1

公开(公告)日：2024-10-24

申请号：US18435757

申请日：2024-02-07

Applicant: Carnegie Mellon University

Inventor： Adam Feinberg ,  Rebecca Duffy ,  Jacqueline Wittmer

IPC: C12N5/00 ,  C12M1/00 ,  C12M1/32 ,  C12N5/071 ,  G01N3/06 ,  G01N3/20 ,  G01N33/483 ,  G01N33/50

CPC classification number: C12N5/0062 ,  C12M23/12 ,  C12M23/26 ,  C12N5/0697 ,  G01N3/066 ,  G01N3/20 ,  G01N33/4833 ,  G01N33/5008 ,  C12N2513/00 ,  G01N2500/00

Abstract: This document describes systems and methods for integrated mechanical loading of tissue. The system includes a three-dimensional tissue comprising organic material. The system includes a strip of bendable material. The strip includes a first region proximate to a first end of the strip coupled to the tissue. The strip includes a second region near a second end of the strip for coupled to the tissue, the second end being opposite the first end, wherein the tissue exerts a force on the strip to bend the strip, the force caused by contraction of the tissue, and wherein the strip exerts a stress on the tissue.

公开(公告)号：US12105094B2

公开(公告)日：2024-10-01

申请号：US18454838

申请日：2023-08-24

Applicant: magtivio b.v

Inventor： Mario Wuttke ,  Viorel Rusu ,  Erik Ruijters ,  Gerbert Schaap ,  Sven Goethel

IPC: G01N33/68 ,  B01L3/00 ,  G01N21/64 ,  G01N33/483

CPC classification number: G01N33/6848 ,  B01L3/502715 ,  B01L3/502753 ,  G01N21/64 ,  G01N33/4833 ,  B01L2300/069 ,  B01L2300/12 ,  G01N2800/52

Abstract: Various embodiments of the present disclosure relate to a method for analyzing target compounds from a fluid or dried biological sample by using a microfluidic sample device including a hollow cartridge and an absorbent body unit.

公开(公告)号：US12094609B2

公开(公告)日：2024-09-17

申请号：US17448886

申请日：2021-09-26

Applicant: Arion Diagnostics, Inc.

Inventor： Alexander Lazarev ,  Pavel Lazarev ,  Delvin Tai Wai Yuk

IPC: G16H50/20 ,  A61B5/00 ,  G01N23/20 ,  G01N23/201 ,  G01N33/483 ,  G06F21/60 ,  G06N3/08 ,  G06Q20/08 ,  G06Q20/32 ,  G16H10/40 ,  G16H10/60 ,  G16H30/20 ,  G16H40/63 ,  G16H40/67

CPC classification number: G16H50/20 ,  A61B5/00 ,  A61B5/4312 ,  G01N23/20 ,  G01N23/201 ,  G01N33/4833 ,  G06F21/602 ,  G06N3/08 ,  G06Q20/085 ,  G06Q20/325 ,  G16H10/40 ,  G16H10/60 ,  G16H30/20 ,  G16H40/63 ,  G16H40/67 ,  G01N2223/0566 ,  G01N2223/6126

Abstract: An animal-tissue analysis and communication system produces a quantitative-diagnostic indicator for animal-tissue analyzed by the system. The system includes an animal-tissue-analyzer subsystem with at least one animal-tissue analyzer constructed to analyze animal tissue and to produce an quantitative-diagnostic indicator. The system also includes a two-way communication subsystem constructed to allow the animal-tissue-analyzer subsystem to send and receive information relevant to the quantitative-diagnostic indicator. The animal-tissue-analyzer subsystem includes at least one tissue diffractometer operatively coupled to a computer database over a network, and is configured for acquisition and transfer of animal-tissue data, and transfer to the computer database over the network. A computer processor is operatively coupled to the tissue diffractometer, and configured to receive, transmit and process the animal-tissue data from the diffractometer to the computer database, using a data analytics algorithm that provides a computer-aided quantitative-diagnostic indicator for a given animal-tissue sample.

公开(公告)号：US20240302253A1

公开(公告)日：2024-09-12

申请号：US18599465

申请日：2024-03-08

Applicant: Elephas Biosciences Corporation

Inventor： Christian Baltes ,  Todd Bakken ,  Wesley Cox-Muranami ,  Jonathan Daniel Oliner ,  Ryan Fischer

IPC: G01N1/28 ,  G01N33/483

CPC classification number: G01N1/286 ,  G01N33/4833 ,  G01N2001/2873

Abstract: The present invention relates to devices, systems, and methods for cutting tissues. In some embodiments, the devices, systems, and methods of the invention relate to cutting tissues into fragments that find use in tissue culture and drug testing applications.

公开(公告)号：US20240299639A1

公开(公告)日：2024-09-12

申请号：US18544592

申请日：2023-12-19

Applicant: Rocin Laboratories, Inc.

Inventor： Robert L. Cucin

IPC: A61M1/00 ,  A61B18/00 ,  G01N33/483 ,  G06T19/00

CPC classification number: A61M1/774 ,  G01N33/4833 ,  G06T19/006 ,  A61B2018/00464 ,  A61B2218/007 ,  A61M2210/1021

Abstract: A 3D-stereoscopic IR-thermographic intra-abdominal visceral fat aspiration system and method employing a powered visceral fat aspiration instrument held by a surgeon or surgical robot, and having an electro-cauterizing, irrigating and photo-ablating twin-cannula assembly for use in safely removing visceral fat from the mesenteric region of a patient, through one or more small incisions in the patient's body, while supporting real-time cytokine-sensing and profiling with Augmented-Reality (AR) guidance and visual sample tagging.

公开(公告)号：US20240296949A1

公开(公告)日：2024-09-05

申请号：US18503002

申请日：2023-11-06

Applicant: VisionGate, Inc.

Inventor： Michael G. Meyer ,  David Wilbur ,  Chris Presley ,  Celeste Hamilton ,  Rahul Katdare ,  Greg Zick ,  Frances Lakers

IPC: G16H50/20 ,  G01N15/14 ,  G01N15/1434 ,  G01N33/483 ,  G16H10/60 ,  G16H30/40

CPC classification number: G16H50/20 ,  G01N15/1434 ,  G01N33/4833 ,  G16H10/60 ,  G16H30/40 ,  G01N2015/1402 ,  G01N2015/1445

Abstract: A cell classification system includes an optical tomography system and a processor operable to generate a plurality of 2D images and a plurality of pseudo-projection images of a cell. The processor executes instructions that cause the processor to: generate a 3D image of the cell using the pseudo-projection images; apply digital enhancement to a 2D or 3D image to improve determination of boundaries of structures with the cell that provide indicia of cell features; analyze at least one of the cell features or 2D or 3D images using AI-based cell characterization to characterize the cell as normal or as having abnormal features by analyzing the boundaries of structures; create a Normal Cell Gallery comprising images characterized by AI-based characterization as normal; create a Diagnostic Cell Gallery with images characterized by AI-based characterization as having abnormal features; display at least the Diagnostic Cell Gallery; and record a user classification.

公开(公告)号：US20240264141A1

公开(公告)日：2024-08-08

申请号：US18563869

申请日：2022-10-21

Applicant: Korea University Research and Business Foundation

Inventor： Sung-Hoi HONG ,  Min-Jae KIM

IPC: G01N33/483 ,  G06T7/00

CPC classification number: G01N33/4833 ,  G06T7/0016 ,  G06T2207/20081 ,  G06T2207/20084 ,  G06T2207/30024

Abstract: The present invention relates to a method and device for cell discrimination, using artificial intelligence and, in the present invention, when various types of cells are cultured in various media, the fine morphology of the initially changing cells may be learned to observe only cell images, thus distinguishing and determining the unique characteristics of the cells. The method for cell discrimination using artificial intelligence according to the present invention may include an inputting step of inputting cell images and a discriminating step of discriminating at least one of various cell types, various culturing conditions, and various culturing times corresponding to the input cell image using a deep learning-based discriminating model.

公开(公告)号：US20240219701A1

公开(公告)日：2024-07-04

申请号：US18419166

申请日：2024-01-22

Applicant: 10x Genomics, Inc.

Inventor： Augusto Manuel Tentori ,  Rajiv Bharadwaj ,  Felice Alessio Bava

IPC: G02B21/26 ,  G01N33/483 ,  G01N35/00 ,  G02B21/34 ,  G02B21/36

CPC classification number: G02B21/26 ,  G01N33/4833 ,  G01N35/00732 ,  G02B21/34 ,  G02B21/365 ,  G01N2035/00752

Abstract: A sample holder includes a first member featuring a first retaining mechanism configured to retain a first substrate that includes a sample, a second member featuring a second retaining mechanism configured to retain a second substrate that includes a reagent medium, and an alignment mechanism connected to at least one of the first and second members, and configured to align the first and second members such that the sample contacts at least a portion of the reagent medium when the first and second members are aligned.