公开(公告)号：US20240368356A1

公开(公告)日：2024-11-07

申请号：US18683230

申请日：2022-08-12

Applicant: THE UNIVERSITY OF KANSAS

Inventor： Cory BERKLAND ,  Jian QIAN

IPC: C08J3/12 ,  C08F8/00 ,  C08J3/075 ,  C08J3/24

Abstract: Compositions and methods for making a composition comprising a plurality of polymeric chelator particles comprising a plurality of cross-linked polyamine polymer backbone chains and one or more chelators covalently coupled thereto, wherein at least 90% of the plurality of the polymeric chelator particles have a particle size of 300 μm or less. Also disclosed are methods of using the composition, e.g., for removing metal from a medium or treating iron overload disease.

公开(公告)号：US20140202693A1

公开(公告)日：2014-07-24

申请号：US14143169

申请日：2013-12-30

Applicant: The University of Kansas ,  CONOCOPHILLIPS COMPANY

Inventor： Huili GUAN ,  Cory BERKLAND ,  Ahmad MORADI-ARAGHI ,  Jenn-Tai LIANG ,  Terry M. CHRISTIAN ,  Riley B. Needham ,  Min CHENG ,  Faye Lynn SCULLY ,  James H. HEDGES

IPC: C09K8/588

CPC classification number: C09K8/588 ,  C08L1/286 ,  C08L5/00

Abstract: The instant application relates to nanogels or compositions that hold multivalent metal ions until some level of nanogel degradation has occurred, then slowly release the multivalent metal ions for gelation with carboxylate containing polymers. Compositions comprising such nanogels, together with polymers that can be crosslinked with multivalent metal ions, allow the deployment of such mixtures in various applications, and greatly increased gelation times.

Abstract translation: 本申请涉及保持多价金属离子直到发生一定程度的纳米凝胶降解的纳米凝胶或组合物，然后用含羧酸酯的聚合物缓慢释放多价金属离子用于凝胶化。 包含这些纳米凝胶的组合物以及可与多价金属离子交联的聚合物允许在各种应用中部署这些混合物，并大大增加凝胶化时间。

公开(公告)号：US20190314554A1

公开(公告)日：2019-10-17

申请号：US16428534

申请日：2019-05-31

Applicant: THE UNIVERSITY OF KANSAS

Inventor： Michael DETAMORE ,  Emily BECK ,  Stevin GEHRKE ,  Cory BERKLAND

IPC: A61L27/48 ,  A61L27/38 ,  A61L27/50 ,  A61L27/20 ,  A61L27/52 ,  A61L27/54

Abstract: An implantable hydrogel precursor composition can include: a cross-linkable polymer matrix that is biocompatible; and a plurality of polymer particles in the cross-linkable polymer matrix. The cross-linkable polymer matrix can include a cross-linkable hyaluronic acid polymer that has cross-linkable functional groups. The hyaluronic acid polymer can be a methacrylated hyaluronic acid polymer. The methacrylated hyaluronic acid polymer can have a molecular weight from about 500 kDa to about 1.8 MDa. The polymer particles can include a cross-linked hyaluronic acid. The cross-linkable polymer matrix having the polymer particles has a yield stress. The cross-linkable polymer matrix having the polymer particles has shape retention at physiological temperatures. The composition can include live cells in the cross-linkable polymer matrix. The composition can include a biologically active agent in the cross-linkable polymer matrix.