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    Benzofuran derivative
    3.
    发明授权
    Benzofuran derivative 失效
    苯并呋喃衍生物

    公开(公告)号：US07531537B2

    公开(公告)日：2009-05-12

    申请号：US10508512

    申请日：2003-03-27

    申请人： Takayuki Kawaguchi ,  Hidenori Akatsuka ,  Toru Iijima ,  Yasunori Tsuboi ,  Takashi Mitsui ,  Jun Murakami

    发明人： Takayuki Kawaguchi ,  Hidenori Akatsuka ,  Toru Iijima ,  Yasunori Tsuboi ,  Takashi Mitsui ,  Jun Murakami

    IPC分类号： A61K31/5377 ,  A61K31/443 ,  C07D413/14 ,  C07D405/12

    CPC分类号： C07D413/14 ,  C07D307/85 ,  C07D405/12 ,  C07D405/14 ,  C07D417/14

    摘要： The present invention provides a benzofuran derivative of the formula [1]: wherein x is a group of the formula: —N═ or —CH═; Y is an optionally substituted amino group, an optionally substituted cycloalkyl group or an optionally substituted saturated heterocyclic group; A is a single bond, a carbon chain optionally having a double bond within or at the end(s) of the chain, or an oxygen atom; R1 is a hydrogen atom or a halogen atom; Ring B is an optionally substituted benzene ring; and R3 is a hydrogen atom, or a pharmaceutically acceptable salt thereof, which is useful as a medicament, especially as an activated blood coagulation factor X inhibitor.

    摘要翻译： 本发明提供式[1]的苯并呋喃衍生物：其中x是下式的基团：-N-或-CH-; Y是任选取代的氨基，任选取代的环烷基或任选取代的饱和杂环基; A是单键，在链的末端或其末端具有双键的碳链或氧原子; R1是氢原子或卤素原子; 环B是任选取代的苯环; 并且R3是氢原子或其药学上可接受的盐，其可用作药物，特别是作为活化凝血因子X抑制剂。

    Fused furan compound
    4.
    发明申请
    Fused furan compound 失效
    稠化呋喃化合物

    公开(公告)号：US20060094724A1

    公开(公告)日：2006-05-04

    申请号：US10540878

    申请日：2004-01-08

    申请人： Takayuki Kawaguchi ,  Hidenori Akatsuka ,  Toru Iijima ,  Tatsuya Watanabe ,  Jun Murakami ,  Takashi Mitsui

    发明人： Takayuki Kawaguchi ,  Hidenori Akatsuka ,  Toru Iijima ,  Tatsuya Watanabe ,  Jun Murakami ,  Takashi Mitsui

    IPC分类号： A61K31/498 ,  A61K31/4741 ,  C07D491/02

    CPC分类号： C07D491/04 ,  C07D213/75

    摘要： The present invention provides a condensed furan compound of the formula (I): wherein Ring X is benzene, pyridine, or the like; Y is an optionally substituted amino, an optionally substituted cycloalkyl, an optionally substituted aryl, an optionally substituted saturated heterocyclic group, an optionally substituted unsaturated heterocyclic group; A is a single bond, lower alkylene, lower alkenylidene, lower alkenylene or an oxygen atom; R3 is hydrogen or the like; and, R4 is hydrogen, or the like, or pharmaceutically acceptable salts thereof, which is useful as a medicament, particularly, as an activated blood coagulation factor X inhibitor.

    摘要翻译： 本发明提供式（I）的缩合呋喃化合物：其中环X为苯，吡啶等; Y是任选取代的氨基，任选取代的环烷基，任选取代的芳基，任选取代的饱和杂环基，任选取代的不饱和杂环基; A是单键，低级亚烷基，低级亚烯基，低级亚烯基或氧原子; R 3是氢等; 和R 4是氢等，或其药学上可接受的盐，其可用作药物，特别是作为活化凝血因子X抑制剂。

    Condensed furan compounds
    5.
    发明授权
    Condensed furan compounds 失效
    稠化呋喃化合物

    公开(公告)号：US07737161B2

    公开(公告)日：2010-06-15

    申请号：US12320583

    申请日：2009-01-29

    申请人： Takayuki Kawaguchi ,  Hidenori Akatsuka ,  Toru Iijima ,  Tatsuya Watanabe ,  Jun Murakami ,  Takashi Mitsui

    发明人： Takayuki Kawaguchi ,  Hidenori Akatsuka ,  Toru Iijima ,  Tatsuya Watanabe ,  Jun Murakami ,  Takashi Mitsui

    IPC分类号： A61K31/444 ,  C07D491/048

    CPC分类号： C07D491/04 ,  C07D213/75

    摘要： The present invention provides a condensed furan compound of the formula (I): wherein Ring X is benzene, pyridine, or the like; Y is an optionally substituted amino, an optionally substituted cycloalkyl, an optionally substituted aryl, an optionally substituted saturated heterocyclic group, an optionally substituted unsaturated heterocyclic group; A is a single bond, lower alkylene, lower alkenylidene, lower alkenylene or an oxygen atom; R3 is hydrogen or the like; and, R4 is hydrogen, or the like, or pharmaceutically acceptable salts thereof, which is useful as a medicament, particularly, as an activated blood coagulation factor X inhibitor.

    摘要翻译： 本发明提供式（I）的缩合呋喃化合物：其中环X为苯，吡啶等; Y是任选取代的氨基，任选取代的环烷基，任选取代的芳基，任选取代的饱和杂环基，任选取代的不饱和杂环基; A是单键，低级亚烷基，低级亚烯基，低级亚烯基或氧原子; R3是氢等; 和R4为氢等，或其药学上可接受的盐，其可用作药物，特别是活性凝血因子X抑制剂。

    Fused furan compound
    6.
    发明授权
    Fused furan compound 失效
    稠化呋喃化合物

    公开(公告)号：US07514449B2

    公开(公告)日：2009-04-07

    申请号：US10540878

    申请日：2004-01-08

    申请人： Takayuki Kawaguchi ,  Hidenori Akatsuka ,  Toru Iijima ,  Tatsuya Watanabe ,  Jun Murakami ,  Takashi Mitsui

    发明人： Takayuki Kawaguchi ,  Hidenori Akatsuka ,  Toru Iijima ,  Tatsuya Watanabe ,  Jun Murakami ,  Takashi Mitsui

    IPC分类号： A61K31/444 ,  C07D491/048

    CPC分类号： C07D491/04 ,  C07D213/75

    摘要： The present invention provides a condensed furan compound of the formula (I): wherein Ring X is benzene, pyridine, or the like; Y is an optionally substituted amino, an optionally substituted cycloalkyl, an optionally substituted aryl, an optionally substituted saturated heterocyclic group, an optionally substituted unsaturated heterocyclic group; A is a single bond, lower alkylene, lower alkenylidene, lower alkenylene or an oxygen atom; R3 is hydrogen or the like; and, R4 is hydrogen, or the like, or pharmaceutically acceptable salts thereof, which is useful as a medicament, particularly, as an activated blood coagulation factor X inhibitor.

    摘要翻译： 本发明提供式（I）的缩合呋喃化合物：其中环X为苯，吡啶等; Y是任选取代的氨基，任选取代的环烷基，任选取代的芳基，任选取代的饱和杂环基，任选取代的不饱和杂环基; A是单键，低级亚烷基，低级亚烯基，低级亚烯基或氧原子; R3是氢等; 和R4为氢等，或其药学上可接受的盐，其可用作药物，特别是活性凝血因子X抑制剂。

    Condensed furan compounds
    7.
    发明申请
    Condensed furan compounds 失效
    稠化呋喃化合物

    公开(公告)号：US20090156803A1

    公开(公告)日：2009-06-18

    申请号：US12320583

    申请日：2009-01-29

    申请人： Takayuki Kawaguchi ,  Hidenori Akatsuka ,  Toru Iijima ,  Tatsuya Watanabe ,  Jun Murakami ,  Takashi Mitsui

    发明人： Takayuki Kawaguchi ,  Hidenori Akatsuka ,  Toru Iijima ,  Tatsuya Watanabe ,  Jun Murakami ,  Takashi Mitsui

    IPC分类号： C07D491/048

    CPC分类号： C07D491/04 ,  C07D213/75

    摘要： The present invention provides a condensed furan compound of the formula (I): wherein Ring X is benzene, pyridine, or the like; Y is an optionally substituted amino, an optionally substituted cycloalkyl, an optionally substituted aryl, an optionally substituted saturated heterocyclic group, an optionally substituted unsaturated heterocyclic group; A is a single bond, lower alkylene, lower alkenylidene, lower alkenylene or an oxygen atom; R3 is hydrogen or the like; and, R4 is hydrogen, or the like, or pharmaceutically acceptable salts thereof, which is useful as a medicament, particularly, as an activated blood coagulation factor X inhibitor.

    摘要翻译： 本发明提供式（I）的缩合呋喃化合物：其中环X为苯，吡啶等; Y是任选取代的氨基，任选取代的环烷基，任选取代的芳基，任选取代的饱和杂环基，任选取代的不饱和杂环基; A是单键，低级亚烷基，低级亚烯基，低级亚烯基或氧原子; R3是氢等; 和R4为氢等，或其药学上可接受的盐，其可用作药物，特别是活性凝血因子X抑制剂。

    Amide type carboxamide derivative
    9.
    发明申请
    Amide type carboxamide derivative 失效
    酰胺型羧酰胺衍生物

    公开(公告)号：US20060287329A1

    公开(公告)日：2006-12-21

    申请号：US10571900

    申请日：2004-09-24

    申请人： Takayuki Kawaguchi ,  Hidenori Akatsuka ,  Masamichi Morimoto ,  Tatsuya Watanabe ,  Toru Iijima ,  Jun Murakami

    发明人： Takayuki Kawaguchi ,  Hidenori Akatsuka ,  Masamichi Morimoto ,  Tatsuya Watanabe ,  Toru Iijima ,  Jun Murakami

    IPC分类号： A61K31/50

    CPC分类号： C07C237/42 ,  C07D409/12

    摘要： The present invention provides an amide-type carboxamide derivative of the formula [1]: wherein X is a group of the formula: —N═ or the formula: —CH═; R1 is a halogen atom, a lower alkyl group, and the like; R2 is a group of the formula: and the like; Y1 and Y2 are the same or different and each is a group selected from a halogen atom, a lower alkyl group, a lower alkoxy group, and the like; Ring A is phenyl group, and the like, or a pharmaceutically acceptable salt thereof, which is useful as an inhibitor of FXa.

    摘要翻译： 本发明提供式[1]的酰胺型羧酰胺衍生物：其中X是下式的基团：-N-或式：-CH-; R 1是卤素原子，低级烷基等; R 2是下式的基团：等等; Y 1和Y 2相同或不同，各自为选自卤素原子，低级烷基，低级烷氧基等的基团; 环A是可用作FXa抑制剂的苯基等，或其药学上可接受的盐。

    Carbamoyl-type benzofuran derivatives
    10.
    发明申请
    Carbamoyl-type benzofuran derivatives 失效
    氨基甲酰型苯并呋喃衍生物

    公开(公告)号：US20060247273A1

    公开(公告)日：2006-11-02

    申请号：US10571904

    申请日：2004-09-24

    申请人： Takayuki Kawaguchi ,  Hidenori Akatsuka ,  Masamichi Morimoto ,  Toru Iijima ,  Jun Murakami

    发明人： Takayuki Kawaguchi ,  Hidenori Akatsuka ,  Masamichi Morimoto ,  Toru Iijima ,  Jun Murakami

    IPC分类号： A61K31/445

    CPC分类号： C07D405/12 ,  C07D405/14

    摘要： The present invention provides a carbamoyl-type benzofuran derivative of the formula [1]: wherein Ring Z is a group of the formula: etc.; A is a single bond, and the like; Y is a cycloalkanediyl group, etc.; R4 and R5 are the same or different and each is an optionally substituted lower alkyl group, etc.; R1 is a halogen atom, etc.; Ring B of the formula: is an optionally substituted benzene ring; and R3 is a hydrogen atom. etc., or a pharmaceutically acceptable salt thereof, which is useful as an FXa inhibitor.

    摘要翻译： 本发明提供式[1]的氨基甲酰基型苯并呋喃衍生物：其中环Z是下式的基团：等等; A是单键等; Y是环烷二基等; R 4和R 5相同或不同，各自为任选取代的低级烷基等; R 1是卤素原子等; 下式的环B是任选取代的苯环; R 3是氢原子。 等等，或其药学上可接受的盐，其可用作FXa抑制剂。