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![Derivatives of [6,7-dihydro-5H-imidazo[1,2--a]imidazole-3-sulfonyl]-pyrrolidine-2-carboxylic acid amide](/abs-image/US/2008/12/09/US07462637B2/abs.jpg.150x150.jpg)
1.发明授权Derivatives of [6,7-dihydro-5H-imidazo[1,2--a]imidazole-3-sulfonyl]-pyrrolidine-2-carboxylic acid amide 有权[6,7-二氢-5H-咪唑并[1,2-a]咪唑-3-磺酰基] - 吡咯烷-2-甲酸酰胺的衍生物公开(公告)号：US07462637B2
公开(公告)日：2008-12-09
申请号：US10969698
申请日：2004-10-20
IPC分类号： A61K31/4188 , A61K31/5375 , C07D235/02 , C07D403/12
CPC分类号： C07D487/04 , A61K31/4188
摘要： Derivatives of 6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonyl]-pyrrolidine-2-carboxylic acid amide which exhibit good inhibitory effect upon the interaction of CAMs and Leukointegrins and are thus useful in the treatment of inflammatory disease.
摘要翻译： 6,7-二氢-5H-咪唑并[1,2-a]咪唑-3-磺酰基]吡咯烷-2-甲酸酰胺的衍生物，其对CAM和白血球素蛋白的相互作用具有良好的抑制作用，因此可用于 治疗炎症性疾病。
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公开(公告)号：US07601714B2
公开(公告)日：2009-10-13
申请号：US11175476
申请日：2005-07-06
申请人： Antonio J. M. Barbosa, Jr. , Steven Richard Brunette , Eugene Richard Hickey , Jin Mi Kim , Michael David Lawlor , René Marc Lemieux , Bryan McKibben , Matt Aaron Tschantz , Hui Yu
发明人： Antonio J. M. Barbosa, Jr. , Steven Richard Brunette , Eugene Richard Hickey , Jin Mi Kim , Michael David Lawlor , René Marc Lemieux , Bryan McKibben , Matt Aaron Tschantz , Hui Yu
IPC分类号： C07D239/48 , C07D403/12 , A61K31/505
CPC分类号： C07D239/48 , C07D401/12 , C07D403/12
摘要： Disclosed are novel compounds of formula (I): wherein X, Y, R1, R2 and R3 are as defined herein, which are useful as inhibitors of PKC-theta and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC-theta, including immunological disorders and type II diabetes. This invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译： 公开了式（I）的新化合物：其中X，Y，R 1，R 2和R 3如本文所定义，其可用作PKC-θ的抑制剂，因此可用于治疗介导的多种疾病和病症 通过PKC-θ的活性持续，包括免疫学障碍和II型糖尿病。 本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。
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![Derivatives of [6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonyl]-pyrrolidine-2-carboxylic acid amide](/abs-image/US/2005/02/08/US06852748B1/abs.jpg.150x150.jpg)
3.发明授权Derivatives of [6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonyl]-pyrrolidine-2-carboxylic acid amide 有权[6,7-二氢-5H-咪唑并[1,2-a]咪唑-3-磺酰基] - 吡咯烷-2-甲酸酰胺的衍生物公开(公告)号：US06852748B1
公开(公告)日：2005-02-08
申请号：US10685638
申请日：2003-10-15
IPC分类号： A61K31/4166 , A61K31/4188 , A61K31/5375 , A61P29/00 , C07D235/02 , C07D403/12 , C07D413/02 , C07D487/04
CPC分类号： C07D487/04 , A61K31/4188
摘要： Derivatives of 6,7-dihydro-5H-imidazo[1,2-α]imidazole-3-sulfonyl]-pyrrolidine-2-carboxylic acid amide which exhibit good inhibitory effect upon the interaction of CAMs and Leukointegrins and are thus useful in the treatment of inflammatory disease.
摘要翻译： 6,7-二氢-5H-咪唑并[1,2-α]咪唑-3-磺酰基] - 吡咯烷-2-甲酸酰胺的衍生物，其对CAM和白血球素蛋白的相互作用具有良好的抑制作用，因此可用于 治疗炎症性疾病。
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![Derivatives of [6,7-dihydro-5H-imidazo[1,2-α]imidazole-3-sulfonylamino]-propionamide](/abs-image/US/2009/09/15/US07589115B2/abs.jpg.150x150.jpg)
4.发明授权Derivatives of [6,7-dihydro-5H-imidazo[1,2-α]imidazole-3-sulfonylamino]-propionamide 有权[6,7-二氢-5H-咪唑并[1,2-a]咪唑-3-磺酰基氨基] - 丙酰胺的衍生物公开(公告)号：US07589115B2
公开(公告)日：2009-09-15
申请号：US11872276
申请日：2007-10-15
IPC分类号： A61K31/4162 , C07D403/02
CPC分类号： A61K31/4166 , A61K31/506 , A61K31/5355 , C07D487/04
摘要： Derivatives of [6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonylamino]-propionamide which exhibit good inhibitory effect upon the interaction of CAMs and Leukointegrins and are thus useful in the treatment of inflammatory disease.
摘要翻译： [6,7-二氢-5H-咪唑并[1,2-a]咪唑-3-磺酰氨基] - 丙酰胺的衍生物，其对CAM和白细胞整合素的相互作用具有良好的抑制作用，因此可用于治疗炎性疾病。
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![Derivatives of [6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonylamino]-propionamide](/abs-image/US/2007/12/04/US07304067B2/abs.jpg.150x150.jpg)
5.发明授权Derivatives of [6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonylamino]-propionamide 有权[6,7-二氢-5H-咪唑并[1,2-a]咪唑-3-磺酰基氨基] - 丙酰胺的衍生物公开(公告)号：US07304067B2
公开(公告)日：2007-12-04
申请号：US11034701
申请日：2005-01-13
IPC分类号： A61K31/505 , A61K31/4166 , C07D235/02 , C07D403/10
CPC分类号： A61K31/4166 , A61K31/506 , A61K31/5355 , C07D487/04
摘要： Derivatives of [6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonylamino]-propionamide which exhibit good inhibitory effect upon the interaction of CAMs and Leukointegrins and are thus useful in the treatment of inflammatory disease.
摘要翻译： [6,7-二氢-5H-咪唑并[1,2-a]咪唑-3-磺酰氨基] - 丙酰胺的衍生物，其对CAM和白细胞整合素的相互作用具有良好的抑制作用，因此可用于治疗炎性疾病。
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![Derivatives of [6,7-dihydro-5H-imidazol[1,2-a]imidazole-3-sulfonylamino]-propionamide](/abs-image/US/2008/03/18/US07345074B2/abs.jpg.150x150.jpg)
6.发明授权Derivatives of [6,7-dihydro-5H-imidazol[1,2-a]imidazole-3-sulfonylamino]-propionamide 有权[6,7-二氢-5H-咪唑并[1,2-a]咪唑-3-磺酰基氨基] - 丙酰胺的衍生物公开(公告)号：US07345074B2
公开(公告)日：2008-03-18
申请号：US10969105
申请日：2004-10-20
IPC分类号： A61K31/4166 , C07D235/02 , C07D403/02
CPC分类号： A61K31/4166 , A61K31/506 , A61K31/5355 , C07D487/04
摘要： Derivatives of [6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonylamino]-propionamide which exhibit good inhibitory effect upon the interaction of CAMs and Leukointegrins and are thus useful in the treatment of inflammatory disease.
摘要翻译： [6,7-二氢-5H-咪唑并[1,2-a]咪唑-3-磺酰氨基] - 丙酰胺的衍生物，其对CAM和白细胞整合素的相互作用具有良好的抑制作用，因此可用于治疗炎性疾病。
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![Derivatives of [6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonylamino]-propionamide](/abs-image/US/2005/01/18/US06844360B2/abs.jpg.150x150.jpg)
公开(公告)号：US06844360B2
公开(公告)日：2005-01-18
申请号：US10686073
申请日：2003-10-15
IPC分类号： A61P37/00 , C07D487/04 , A61K31/4166 , C07D235/02 , C07D403/02
CPC分类号： A61K31/4166 , A61K31/506 , A61K31/5355 , C07D487/04
摘要： Derivatives of [6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonylamino]-propionamide which exhibit good inhibitory effect upon the interaction of CAMs and Leukointegrins and are thus useful in the treatment of inflammatory disease.
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