公开(公告)号：US06251432B1

公开(公告)日：2001-06-26

申请号：US09345915

申请日：1999-07-01

申请人： Terrence B. Mazer ,  Joseph E. Walton ,  Barbara S. Arnholt ,  Monty L. Evans ,  Ronita K. Geckle ,  Daniel Hamilton ,  John J. Kropczynski, Jr. ,  Frank A. Murawski ,  Larry G. Tucker ,  Sherri A. Walker ,  Michael V. Walsh ,  Rhonda Cole Walsh

发明人： Terrence B. Mazer ,  Joseph E. Walton ,  Barbara S. Arnholt ,  Monty L. Evans ,  Ronita K. Geckle ,  Daniel Hamilton ,  John J. Kropczynski, Jr. ,  Frank A. Murawski ,  Larry G. Tucker ,  Sherri A. Walker ,  Michael V. Walsh ,  Rhonda Cole Walsh

IPC分类号： A61K930

CPC分类号： A61K9/286 ,  A61K9/2054 ,  A61K9/209 ,  A61K9/2866

摘要： Dosage form unit is provided to deliver one or more beneficial agents into a fluid, such as liquid enteral nutritional product. The dosage form unit includes a core containing at least one beneficial agent, preferably a marker dye, which is dispersible in the fluid. The core also contains a compatible binding agent to bind the beneficial agent together. Additional components of the core may include a plasticizer, a standard flow agent, a lubricant, additional tableting aids and at least one hydrophilic agent. A latex coating encases the core. The latex coating includes a mixture containing a substantially hydrophobic base material, preferably formed from an emulsion of cellulose acetate microspheres, which is capable of defining a matrix-type membrane, and at least one hydrophilic component being dispersible in the fluid. A dispersible beneficial agent is preferred as one of the hydrophilic components of the latex coating to allow immediate release of the beneficial agent therefrom. A method of making the dosage form unit also is provided.

摘要翻译： 提供剂量形式单元以将一种或多种有益剂递送到流体中，例如液体肠内营养产品。 剂型单元包括含有可分散在流体中的至少一种有益试剂，优选标记染料的核心。 核心还含有一种相容的结合剂以将有益剂结合在一起。 芯的另外的组分可以包括增塑剂，标准流动剂，润滑剂，另外的压片助剂和至少一种亲水剂。 乳胶涂层包裹核心。 胶乳涂层包括含有基本上疏水的基材的混合物，优选由乙酸纤维素微球的乳液形成，其能够限定基质型膜，以及至少一种可分散在流体中的亲水组分。 作为胶乳涂料的亲水组分之一，优选可分散的有益剂，以便立即从其中释放有益剂。 还提供了制备剂型单元的方法。

公开(公告)号：US06620434B2

公开(公告)日：2003-09-16

申请号：US09852364

申请日：2001-05-10

申请人： Terrence B. Mazer ,  Joseph E. Walton ,  Barbara S. Arnholt ,  Monty L. Evans ,  Ronita K. Geckle ,  Daniel Hamilton ,  John J. Kropczynski, Jr. ,  Frank A. Murawski ,  Larry G. Tucker ,  Sherri A. Walker ,  Michael V. Walsh ,  Rhonda Cole Walsh

发明人： Terrence B. Mazer ,  Joseph E. Walton ,  Barbara S. Arnholt ,  Monty L. Evans ,  Ronita K. Geckle ,  Daniel Hamilton ,  John J. Kropczynski, Jr. ,  Frank A. Murawski ,  Larry G. Tucker ,  Sherri A. Walker ,  Michael V. Walsh ,  Rhonda Cole Walsh

IPC分类号： A61K936

CPC分类号： A61K9/286 ,  A61K9/2054 ,  A61K9/209 ,  A61K9/2866

摘要： Dosage form unit is provided to deliver one or more beneficial agents into a fluid, such as liquid enteral nutritional product. The dosage form unit includes a core containing at least one beneficial agent, preferably a marker dye, which is dispersible in the fluid. The core also contains a compatible binding agent to bind the beneficial agent together. Additional components of the core may include a plasticizer, a standard flow agent, a lubricant, additional tableting aids and at least one hydrophilic agent. A latex coating encases the core. The latex coating includes a mixture containing a substantially hydrophobic base material, preferably formed from an emulsion of cellulose acetate microspheres, which is capable of defining a matrix-type membrane, and at least one hydrophilic component being dispersible in the fluid. A dispersible beneficial agent is preferred as one of the hydrophilic components of the latex coating to allow immediate release of the beneficial agent therefrom. A method of making the dosage form unit also is provided.

摘要翻译： 提供剂量形式单元以将一种或多种有益剂递送到流体中，例如液体肠内营养产品。 剂型单元包括含有可分散在流体中的至少一种有益试剂，优选标记染料的核心。 核心还含有一种相容的结合剂以将有益剂结合在一起。 芯的另外的组分可以包括增塑剂，标准流动剂，润滑剂，另外的压片助剂和至少一种亲水剂。 乳胶涂层包裹核心。 胶乳涂层包括含有基本上疏水的基材的混合物，优选由乙酸纤维素微球的乳液形成，其能够限定基质型膜，以及至少一种可分散在流体中的亲水组分。 作为胶乳涂料的亲水组分之一，优选可分散的有益剂，以便立即从其中释放有益剂。 还提供了制备剂型单元的方法。