公开(公告)号：US5073553A

公开(公告)日：1991-12-17

申请号：US440069

申请日：1989-11-22

申请人： Tetsuhide Kamijo ,  Arao Ujiie ,  Naoyuki Tsutsumi ,  Atsushi Tsubaki

发明人： Tetsuhide Kamijo ,  Arao Ujiie ,  Naoyuki Tsutsumi ,  Atsushi Tsubaki

IPC分类号： C07D491/04 ,  C07D491/048

CPC分类号： C07D491/04

摘要： Benzofuro[3,2-c]quinoline compounds of the formula: ##STR1## wherein A represents a group of the formula of --CH.sub.2) .sub.m or --CH.sub.2 CH(OH)CH.sub.2 --; Y represents an N,N-di-alkylamino group, an N-mono-alkylamino group or a nitrogen atom-containing aliphatic geterocyclic group; n represents 0 or 1; m represents an integer of from 1 to 3, and pharmaceutically acceptable acid addition salts thereof, possess a strong inhibitory action on bone resorption, a stimulatory effect on ossification.

公开(公告)号：US5023261A

公开(公告)日：1991-06-11

申请号：US321248

申请日：1989-03-09

申请人： Tetsuhide Kamijo ,  Arao Ujiie ,  Hiromu Harada ,  Naoyuki Tsutsumi ,  Atsushi Tsubaki ,  Toshiaki Yamaguchi ,  Hideo Nagata

发明人： Tetsuhide Kamijo ,  Arao Ujiie ,  Hiromu Harada ,  Naoyuki Tsutsumi ,  Atsushi Tsubaki ,  Toshiaki Yamaguchi ,  Hideo Nagata

IPC分类号： A61K31/435 ,  A61K31/47 ,  A61P19/10 ,  A61P43/00 ,  C07D491/04 ,  C07D491/048

CPC分类号： C07D491/04

摘要： Benzofuro[3,2-c]quinoline compounds of the general formula: ##STR1## wherein (1) each of R.sup.1 and R.sup.2 is the same, and represent a group of the formula of --OR.sup.3 in which R.sup.3 represents a carbamoyl group, an N-mono-alkylcarbamoyl group, an N,N-dialkylcarbamoyl group, an alkylsulfonyl group, a formyl group or an aliphatic acyl group which may have an alkoxycarbonyl group as a substituent; m represents zero, 1 or 2; n represents zero or 1; with the proviso that n is not zero when m is zero,(2) each of R.sup.1 and R.sup.2 is different, and represent a hydroxy group or an N,N-di-alkylcarbamoyloxy group; m represents 1 or 2; n represents 1, possess a strong inhibitory action on bone resorption and a stimulatory effect on ossification. Some benzofuro[3,2-c]quinoline compounds of the above general formula also possess a stimulatory effect on longitudinal bone growth, and thus are useful for the prevention or treatment of osteoporosis.

公开(公告)号：US5177069A

公开(公告)日：1993-01-05

申请号：US623107

申请日：1990-12-06

申请人： Makio Kitazawa ,  Masuo Akahane ,  Yasushi Nakano ,  Atsushi Tsubaki ,  Kazuaki Sato ,  Masaaki Ban ,  Michihiro Kobayashi

发明人： Makio Kitazawa ,  Masuo Akahane ,  Yasushi Nakano ,  Atsushi Tsubaki ,  Kazuaki Sato ,  Masaaki Ban ,  Michihiro Kobayashi

IPC分类号： C07C317/44 ,  C07C323/52

CPC分类号： C07C323/52 ,  C07C317/44

摘要： The present invention provides a novel class of naphthylsulfonylalkanoic acid compounds such as a structure corrresponding to the formula: ##STR1## or a pharmaceutically acceptable salt thereof. A present invention naphthylsulfonylalkanoic acid compound is useful for prevention or treatment of irritable bowel syndrome, biliary dyskinesia and acute pancreatitis.

公开(公告)号：US5202335A

公开(公告)日：1993-04-13

申请号：US860023

申请日：1992-03-30

申请人： Fumiyasu Sato ,  Atsushi Tsubaki ,  Hiroshi Hokari ,  Nobuyuki Tanaka ,  Masaru Saito ,  Kenji Akahane ,  Michihiro Kobayashi

发明人： Fumiyasu Sato ,  Atsushi Tsubaki ,  Hiroshi Hokari ,  Nobuyuki Tanaka ,  Masaru Saito ,  Kenji Akahane ,  Michihiro Kobayashi

IPC分类号： C07D209/08 ,  C07D209/44 ,  C07D217/06 ,  C07D409/06

CPC分类号： C07D409/06 ,  C07D209/08 ,  C07D209/44 ,  C07D217/06

摘要： Succinic acid compounds of the formula: ##STR1## wherein A represents a heterocyclic group, a 3 to 8-membered cycloalkyl group or a phenyl group which may have one or more substituents selected from the group of a halogen atom, a lower alkyl group having 1 to 6 carbon atoms and a lower alkoxy group having 1 to 6 carbon atoms; B represents a bicyclic amino group which may have 1 or 2 unsaturated bonds, with the proviso that B bonds to the carbon atom of the carbonyl group at the nitrogen atom; R represents a hydrogen atom or combines each other to form a chemical bond; R.sup.1 represents a hydrogen atom, a lower alkyl group having 1 to 6 carbon atoms or an aralkyl group having 7 to 10 carbon atoms; when there is an asymmetric carbon atom, enantiomers thereof and racemic mixtures thereof; when there are geometrical isomers, each geometrical isomer, E-isomers thereof, Z-isomers thereof, cis-isomers thereof and trans-isomers thereof; and pharmaceutically acceptable salts thereof, enhance insulin secretion and possess a hypoglycemic activity, and are thus useful for the treatment of diabetes.

公开(公告)号：US5145869A

公开(公告)日：1992-09-08

申请号：US683247

申请日：1991-04-11

申请人： Makio Kitazawa ,  Masuo Akahane ,  Yasushi Nakano ,  Atsushi Tsubaki ,  Kazuaki Sato ,  Masaaki Ban ,  Michihiro Kobayashi

发明人： Makio Kitazawa ,  Masuo Akahane ,  Yasushi Nakano ,  Atsushi Tsubaki ,  Kazuaki Sato ,  Masaaki Ban ,  Michihiro Kobayashi

IPC分类号： C07C317/44 ,  C07C323/60

CPC分类号： C07C317/44 ,  C07C323/60

摘要： The present invention provides a novel class of phenylsulfonylalkanoic acid compounds such as a structure corresponding to the formula: ##STR1## or a pharmaceutically acceptable salt thereof. A present invention phenylsulfonylalkanoic acid compound is useful for prevention or treatment of irritable bowel syndrome, biliary dyskinesia and acute pancreatitis.

摘要翻译： 本发明提供了一类新的苯基磺酰基链烷酸化合物，例如对应于下式的结构：或其药学上可接受的盐。 本发明苯磺酰基链烷酸化合物可用于预防或治疗肠易激综合征，胆道运动障碍和急性胰腺炎。