公开(公告)号：US5202335A

公开(公告)日：1993-04-13

申请号：US860023

申请日：1992-03-30

申请人： Fumiyasu Sato ,  Atsushi Tsubaki ,  Hiroshi Hokari ,  Nobuyuki Tanaka ,  Masaru Saito ,  Kenji Akahane ,  Michihiro Kobayashi

发明人： Fumiyasu Sato ,  Atsushi Tsubaki ,  Hiroshi Hokari ,  Nobuyuki Tanaka ,  Masaru Saito ,  Kenji Akahane ,  Michihiro Kobayashi

IPC分类号： C07D209/08 ,  C07D209/44 ,  C07D217/06 ,  C07D409/06

CPC分类号： C07D409/06 ,  C07D209/08 ,  C07D209/44 ,  C07D217/06

摘要： Succinic acid compounds of the formula: ##STR1## wherein A represents a heterocyclic group, a 3 to 8-membered cycloalkyl group or a phenyl group which may have one or more substituents selected from the group of a halogen atom, a lower alkyl group having 1 to 6 carbon atoms and a lower alkoxy group having 1 to 6 carbon atoms; B represents a bicyclic amino group which may have 1 or 2 unsaturated bonds, with the proviso that B bonds to the carbon atom of the carbonyl group at the nitrogen atom; R represents a hydrogen atom or combines each other to form a chemical bond; R.sup.1 represents a hydrogen atom, a lower alkyl group having 1 to 6 carbon atoms or an aralkyl group having 7 to 10 carbon atoms; when there is an asymmetric carbon atom, enantiomers thereof and racemic mixtures thereof; when there are geometrical isomers, each geometrical isomer, E-isomers thereof, Z-isomers thereof, cis-isomers thereof and trans-isomers thereof; and pharmaceutically acceptable salts thereof, enhance insulin secretion and possess a hypoglycemic activity, and are thus useful for the treatment of diabetes.

公开(公告)号：US20110319464A1

公开(公告)日：2011-12-29

申请号：US13228649

申请日：2011-09-09

申请人： Fumiyasu SATO ,  Yoshio FURIHATA

发明人： Fumiyasu SATO ,  Yoshio FURIHATA

IPC分类号： A61K31/4045 ,  A61P9/00 ,  A61P13/08

CPC分类号： A61K31/404

摘要： Patients having symptoms associated with benign prostatic hyperplasia can be treated with a once daily composition containing silodosin or a pharmaceutically acceptable salt thereof.

摘要翻译： 患有与良性前列腺增生症有关的症状的患者可以用含有西洛多辛或其药学上可接受的盐的每日一次组合物治疗。

公开(公告)号：US20080242717A1

公开(公告)日：2008-10-02

申请号：US12038598

申请日：2008-02-27

申请人： Fumiyasu SATO ,  Yoshio Furihata

发明人： Fumiyasu SATO ,  Yoshio Furihata

IPC分类号： A61K31/405 ,  A61P19/02

CPC分类号： A61K31/404

摘要： Patients having symptoms associated with benign prostatic hyperplasia can be treated with a once daily composition containing silodosin or a pharmaceutically acceptable salt thereof.

摘要翻译： 患有与良性前列腺增生症有关的症状的患者可以用含有西洛多辛或其药学上可接受的盐的每日一次组合物治疗。

公开(公告)号：US07973053B2

公开(公告)日：2011-07-05

申请号：US12676265

申请日：2008-10-02

申请人： Fumiyasu Sato ,  Yasunobu Yoshinaka ,  Taro Aoki

发明人： Fumiyasu Sato ,  Yasunobu Yoshinaka ,  Taro Aoki

IPC分类号： A61K31/47

CPC分类号： A61K31/47 ,  A61K31/445 ,  A61K2300/00

摘要： The present invention provides a medicament exhibiting an excellent nerve cell death inhibitory action.The present invention relates to a nerve cell death inhibitor comprising a pitavastatin and donepezil or a salt thereof in combination.

摘要翻译： 本发明提供了显示神经细胞死亡抑制作用优异的药物。 本发明涉及包含匹伐他汀和多奈哌齐或其盐组合的神经细胞死亡抑制剂。

公开(公告)号：US20100173938A1

公开(公告)日：2010-07-08

申请号：US12676265

申请日：2008-10-02

申请人： Fumiyasu Sato ,  Yasunobu Yoshinaka ,  Taro Aoki

发明人： Fumiyasu Sato ,  Yasunobu Yoshinaka ,  Taro Aoki

IPC分类号： A61K31/47 ,  A61P25/28

CPC分类号： A61K31/47 ,  A61K31/445 ,  A61K2300/00

摘要： The present invention provides a medicament exhibiting an excellent nerve cell death inhibitory action.The present invention relates to a nerve cell death inhibitor comprising a pitavastatin and donepezil or a salt thereof in combination.

摘要翻译： 本发明提供了显示神经细胞死亡抑制作用优异的药物。 本发明涉及包含匹伐他汀和多奈哌齐或其盐组合的神经细胞死亡抑制剂。