公开(公告)号：US20240002908A1

公开(公告)日：2024-01-04

申请号：US18036008

申请日：2021-11-05

Applicant: The General Hospital Corporation

Inventor： James T. Kurnick ,  Ian Seymour Dunn ,  Matthew M. Lawler

IPC: C12Q1/6816

CPC classification number: C12Q1/6816 ,  C12Q2600/166

Abstract: The present disclosure provides methods of determining surface glycan density of a cell.

公开(公告)号：US20240016933A1

公开(公告)日：2024-01-18

申请号：US18036047

申请日：2021-11-05

Applicant: The General Hospital Corporation

Inventor： James T. Kurnick ,  Ian Seymour Dunn ,  Matthew M. Lawler

IPC: A61K39/00 ,  C07K16/10 ,  C12N5/0783 ,  C07H15/12 ,  C07K16/28 ,  C07K16/30 ,  A61K35/17

CPC classification number: A61K39/4631 ,  C07K16/1018 ,  C12N5/0636 ,  C07H15/12 ,  C07K16/2803 ,  C07K16/3015 ,  C07K16/1027 ,  A61K35/17 ,  C07K16/2863 ,  A61K2239/13

Abstract: The present disclosure provides methods of anchoring active molecules on the surface of a cell, methods of anchoring at least two active molecules on the surface of a cell, and methods of enhancing an immune response to a target cell in a human.

公开(公告)号：US20240002536A1

公开(公告)日：2024-01-04

申请号：US18035982

申请日：2021-11-05

Applicant: The General Hospital Corporation

Inventor： James T. Kurnick ,  Ian Seymour Dunn ,  Matthew M. Lawler

IPC: C07K16/44 ,  G01N33/53

CPC classification number: C07K16/44 ,  G01N33/5308 ,  C07K2317/92 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/622

Abstract: The present disclosure is directed, at least in part, to click-product binding molecules for recognition of templated assembly products defined by bioorthogonal click groups. Such molecules can be used for therapeutic and diagnostic purposes, including kits for the same.

公开(公告)号：US20230414764A1

公开(公告)日：2023-12-28

申请号：US18035912

申请日：2021-11-05

Applicant: The General Hospital Corporation

Inventor： James T. Kurnick ,  Ian Seymour Dunn ,  Matthew M. Lawler

IPC: A61K47/54

CPC classification number: A61K47/549

Abstract: The present disclosure provides methods of metabolically labeling cells to provide a substrate for assembly of desired molecules, and to bifunctional compounds used in such methods.

公开(公告)号：US20230406839A1

公开(公告)日：2023-12-21

申请号：US18035904

申请日：2021-11-05

Applicant: The General Hospital Corporation

Inventor： James T. Kurnick ,  Ian Seymour Dunn ,  Matthew M. Lawler

IPC: C07D401/12 ,  C07D211/32

CPC classification number: C07D401/12 ,  C07D211/32

Abstract: The present disclosure provides bifunctional compounds and methods of labeling a cell having an azide-modified sugar on its surface by contacting the cell with a bifunctional compound.