公开(公告)号：US20190233459A1

公开(公告)日：2019-08-01

申请号：US16215349

申请日：2018-12-10

申请人： Jiangnan University ,  Max Planck Institute of Colloids and Interfaces

发明人： Jian YIN ,  Jing HU ,  Peter Seeberger ,  Chunjun QIN

IPC分类号： C07H15/12 ,  C07H15/04 ,  C07H13/04 ,  C07H1/00 ,  A61P31/04

CPC分类号： C07H15/12 ,  A61K39/0283 ,  A61P31/04 ,  C07H1/00 ,  C07H13/04 ,  C07H15/04

摘要： The present disclosure discloses the chemical synthesis method of the Plesiomonas shigelloides serotype O51 O-antigen oligosaccharide, belonging to the field of chemistry. Source-abundant D-glucose, L-fucose, D-glucosamine and the like are used as raw materials to prepare three glycosylation building blocks, the synthetic route composed of 11 reaction modules is designed, and through the optimization of protecting group and the optimization of the time of introducing functional group, the preparation of the target oligosaccharide chain is successfully achieved. The oligosaccharide chain prepared in the present disclosure has the advantages of cheap and easy-to-get raw materials, and simple and easy-to-repeat preparation method. The present disclosure will have good application prospects in the aspects of development of new drugs and vaccines of Plesiomonas shigelloides, and the like.

公开(公告)号：US20180116939A1

公开(公告)日：2018-05-03

申请号：US15560879

申请日：2016-03-14

申请人： AMOREPACIFIC CORPORATION

发明人： Jae Won YOU ,  Tae Hun PARK ,  Yong-Jin KIM ,  Jon Hwan LEE

IPC分类号： A61K8/68 ,  A61K8/60 ,  A61Q19/00 ,  A61K31/133 ,  A61P17/10 ,  A61P31/04 ,  C07H15/04 ,  C07C215/10

CPC分类号： A61K8/68 ,  A61K8/60 ,  A61K31/133 ,  A61P17/10 ,  A61P31/04 ,  A61Q19/00 ,  C07C215/10 ,  C07H15/04 ,  C07H15/12

摘要： The present invention relates to a phytospingosine derivative generated by a condensation reaction of phytospingosine and maltose or lactose, which is an aldose-based disaccharide, and to a composition containing the same. The phytospingosine derivative of the present invention has high solubility in water compared with phytospingosine, is easy to formulate since the stabilization problem in a solution is solved, and maintains or further enhances the antibacterial effect of phytospingosine.

公开(公告)号：US09815862B2

公开(公告)日：2017-11-14

申请号：US14653086

申请日：2013-12-18

申请人： Glycom A/S

发明人： Benjámin Podányi ,  Gyula Dekany

IPC分类号： C07H15/12 ,  A23L33/10 ,  A61K31/702 ,  C07H13/04 ,  A23L33/00

CPC分类号： C07H15/12 ,  A23L33/10 ,  A23L33/40 ,  A23V2002/00 ,  C07H13/04

摘要： A crystalline LNnT polymorph IV, characterized in that it displays X-ray powder diffraction reflections, based on a measurement using CuKα radiation, at 8.16, 15.41, 39.14, 23.77, 7.77 and 31.15 2Θ angles, and a crystalline LNnT polymorph V, characterized in that it displays X-ray powder diffraction reflections, based on a measurement using CuKα radiation, at 9.15, 10.26, 19.68, 26.06, 20.61 and 1 1.89 2Θ angles, are provided.

公开(公告)号：US09617293B2

公开(公告)日：2017-04-11

申请号：US15093178

申请日：2016-04-07

申请人： Pfizer Inc.

发明人： Spiros Liras ,  Vincent Mascitti ,  Benjamin Thuma

IPC分类号： C07D493/08 ,  A61K31/35 ,  C07H15/08 ,  C07D309/14 ,  C07H13/04 ,  C07H15/26 ,  A61K31/7008 ,  A61K31/7056 ,  A61K31/706 ,  A61K38/46 ,  C07H15/12 ,  C07K5/065

CPC分类号： A61K31/706 ,  A61K31/7008 ,  A61K31/7056 ,  A61K38/465 ,  A61K47/64 ,  C07D309/14 ,  C07D493/08 ,  C07H13/04 ,  C07H15/08 ,  C07H15/12 ,  C07H15/26 ,  C07K5/06078 ,  C12Y301/00 ,  Y02A50/463

摘要： Compounds of Formula (A) are described herein and the uses thereof for the treatment of diseases, conditions and/or disorders mediated by pharmaceutical compositions and the uses thereof as asialoglycoprotein receptor (ASGPR) targeting agents.

公开(公告)号：US09539336B2

公开(公告)日：2017-01-10

申请号：US14409704

申请日：2013-06-21

申请人： Reinhard Brossmer ,  Horst Prescher

发明人： Reinhard Brossmer ,  Horst Prescher

IPC分类号： A01N43/04 ,  A61K31/70 ,  A61K47/48 ,  C07H15/12 ,  C07H15/18 ,  A61K31/167 ,  A61K31/407 ,  A61K31/704 ,  C07H15/26 ,  A61K31/7012 ,  A61K31/7008

CPC分类号： A61K47/48092 ,  A61K31/167 ,  A61K31/407 ,  A61K31/7008 ,  A61K31/7012 ,  A61K31/704 ,  A61K47/549 ,  C07H15/12 ,  C07H15/18 ,  C07H15/26

摘要： A sialic acid derivative of the formula (I), where the symbols are as defined in the description, is suitable for linking with a cargo for regulating metabolic processes, immune reactions, immunizations or desensitizations of the target organism.

摘要翻译： 式（I）的唾液酸衍生物，其符号如说明书中所定义，适于与用于调节靶生物体的代谢过程，免疫反应，免疫或脱敏的货物连接。

公开(公告)号：US20160102115A1

公开(公告)日：2016-04-14

申请号：US14894297

申请日：2014-05-28

申请人： UNIVERSITE DE PICARDIE JULES VERNE ,  SIPRE

发明人： Cédric Epoune Lingome ,  Anne Wadouachi ,  Gwladys Pourceau ,  Amélie Beury ,  Virginie Gobert-Deveaux

IPC分类号： C07H15/12

CPC分类号： C07H15/12 ,  A01N33/08 ,  A01N33/12 ,  A01N43/16 ,  C07H15/26

摘要： The present invention relates to a novel method for synthesising, without a solvent, N-alkyl-glycosyl(di)amine derivatives represented by the following general formula (I): The invention also concerns the use of N-alkyl-glycosyl(di)amine derivatives represented by the general formula (I), and N-alkyl-glycosyl(di)ammonium quaternary salts represented by the general formula (II) and N-alkyl-glycamine derivatives represented by the general formula (III) obtained from N-alkyl-glycosyl(di)amine derivatives represented by the general formula (I), as antibacterial and/or antifungal agents against phytopathogens.

摘要翻译： 本发明涉及一种没有溶剂合成由以下通式（I）表示的N-烷基 - 糖基（二）胺衍生物的新方法：本发明还涉及N-烷基 - 糖基（二） 由通式（I）表示的胺衍生物和由通式（II）表示的N-烷基 - 糖基（二）铵季盐和由通式（II）表示的N-烷基 - 甘氨酸衍生物，由N- 由通式（I）表示的烷基 - 糖基（二）胺衍生物作为抗植物病原体的抗菌剂和/或抗真菌剂。

公开(公告)号：US09199935B2

公开(公告)日：2015-12-01

申请号：US14246879

申请日：2014-04-07

申请人： Terence D. Butters ,  Raymond A. Dwek ,  George W. J. Fleet ,  Michael Glen Orchard ,  Frances Mary Platt

发明人： Terence D. Butters ,  Raymond A. Dwek ,  George W. J. Fleet ,  Michael Glen Orchard ,  Frances Mary Platt

IPC分类号： C07D211/46 ,  A61K31/445 ,  A61K31/451 ,  A61K45/06 ,  C07H15/12

CPC分类号： C07D211/46 ,  A61K31/445 ,  A61K31/451 ,  A61K45/06 ,  C07H15/12 ,  A61K2300/00

摘要： Compounds of formula (I): wherein R represents various substituent groups, are useful as inhibitors of glucosylceramide synthase.

摘要翻译： 式（I）的化合物：其中R表示各种取代基，可用作葡萄糖神经酰胺合酶的抑制剂。

公开(公告)号：US20150329555A1

公开(公告)日：2015-11-19

申请号：US14714484

申请日：2015-05-18

申请人： Pfizer Inc.

发明人： Spiros Liras ,  Vincent Mascitti ,  Benjamin Thuma

IPC分类号： C07D493/08 ,  C07D309/14

CPC分类号： A61K31/706 ,  A61K31/7008 ,  A61K31/7056 ,  A61K38/465 ,  A61K47/64 ,  C07D309/14 ,  C07D493/08 ,  C07H13/04 ,  C07H15/08 ,  C07H15/12 ,  C07H15/26 ,  C07K5/06078 ,  C12Y301/00 ,  Y02A50/463

摘要： Compounds of Formula (A) are described herein and the uses thereof for the treatment of diseases, conditions and/or disorders mediated by pharmaceutical compositions and the uses thereof as asialoglycoprotein receptor (ASGPR) targeting agents.

摘要翻译： 本文描述了式（A）的化合物及其用于治疗由药物组合物介导的疾病，病症和/或病症及其作为唾液酸糖蛋白受体（ASGPR）靶向剂的用途的用途。

公开(公告)号：US09175097B2

公开(公告)日：2015-11-03

申请号：US13692511

申请日：2012-12-03

申请人： LABORATOIRES VIVACY

发明人： Jeremie Bon Betemps ,  Estelle Piron

IPC分类号： C08B15/00 ,  C08B37/08 ,  C08B37/00 ,  C08L1/28 ,  C08L5/00 ,  C08L5/08 ,  C07H15/12 ,  A61K31/715 ,  A61K8/73 ,  A61Q19/08 ,  A61K31/717 ,  A61K31/722 ,  A61K31/728 ,  A61K31/738 ,  A61K9/00 ,  A61K47/36

CPC分类号： C08B37/0006 ,  A61K8/735 ,  A61K9/0019 ,  A61K31/715 ,  A61K31/717 ,  A61K31/722 ,  A61K31/728 ,  A61K31/738 ,  A61K47/36 ,  A61K2800/91 ,  A61Q19/08 ,  C07H15/12 ,  C08B15/005 ,  C08B37/00 ,  C08B37/003 ,  C08B37/0072 ,  C08L1/286 ,  C08L5/00 ,  C08L5/08

摘要： A process for the simultaneous substitution and crosslinking of a polysaccharide via its hydroxyl functional groups, in an aqueous phase, which includes the following steps: a polysaccharide is placed in an aqueous medium, it is brought into the presence of at least one precursor of a substituent, it is brought into the presence of a crosslinking agent, the substituted and crosslinked polysaccharide is obtained and isolated, wherein process is carried out in the presence of a basic or acidic catalyst, the concentration of which is between 3.16×10−7 and 0.32 mol/L, and at a temperature of less than 60° C. In one embodiment, the polysaccharide is in the form of a gel or hydrogel which is used in particular as augmentation biomaterial.

摘要翻译： 在水相中通过其羟基官能团同时取代和交联多糖的方法，其包括以下步骤：将多糖置于水性介质中，使其进入至少一种前体的存在下， 取代基，得到交联剂的存在下，获得并分离取代和交联的多糖，其中工艺在碱性或酸性催化剂存在下进行，其浓度在3.16×10-7和 0.32mol / L，并且温度低于60℃。在一个实施方案中，多糖是凝胶或水凝胶的形式，特别是用作增强生物材料。

公开(公告)号：US20150152129A1

公开(公告)日：2015-06-04

申请号：US14414971

申请日：2013-07-03

申请人： SynGlyco, Inc.

发明人： A. Stewart Campbell ,  Obadiah J. Plante

IPC分类号： C07H15/12 ,  G01N33/569 ,  C07K16/12 ,  A61K47/48 ,  A61K39/104 ,  A61K39/39

CPC分类号： C07H15/12 ,  A61K39/00 ,  A61K39/104 ,  A61K39/39 ,  A61K47/61 ,  A61K47/646 ,  A61K2039/505 ,  A61K2039/6037 ,  C07K16/1214 ,  C07K2317/20 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/622 ,  C07K2317/76 ,  G01N33/56911 ,  G01N2469/10

摘要： The present invention provides synthetic Pseudomonas aeruginosa lipooligosaccharide (LOS)-based oligosaccharides and conjugates containing various P. aeruginosa serotype-specific oligosaccharide antigens or various core P. aeruginosa oligosaccharide structures or motifs. The invention further provides P. aeruginosa LOS-based immunogenic and immunoprotective compositions and antibodies derived therefrom for diagnosing, treating, and preventing infections caused by P. aeruginosa.

摘要翻译： 本发明提供合成的铜绿假单胞菌脂寡糖（LOS）基寡糖和含有各种铜绿假单胞菌血清型特异性寡糖抗原或各种核心铜绿假单胞菌寡糖结构或基序的缀合物。 本发明还提供了铜绿假单胞菌LOS基的免疫原性和免疫保护组合物及其衍生的抗体用于诊断，治疗和预防由铜绿假单胞菌引起的感染。