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公开(公告)号:US20140057916A1
公开(公告)日:2014-02-27
申请号:US13971369
申请日:2013-08-20
申请人: Thorsten OOST , Dennnis FIEGEN , Christian GNAMM , Sandra HANDSCHUH , Stefan PETERS , Gerald Juergen ROTH
发明人: Thorsten OOST , Dennnis FIEGEN , Christian GNAMM , Sandra HANDSCHUH , Stefan PETERS , Gerald Juergen ROTH
IPC分类号: C07D213/80 , C07D401/12 , C07D413/12 , C07D493/08 , C07D409/12 , C07D405/14 , C07D401/14 , C07D213/82 , C07D405/12
CPC分类号: C07D213/80 , C07D213/82 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D493/08
摘要: This invention relates to substituted 4-pyridones of formula 1and their use as inhibitors of neutrophil elastase activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of pulmonary, gastrointestinal and genitourinary diseases, inflammatory diseases of the skin and the eye and other auto-immune and allergic disorders, allograft rejection, and oncological diseases.