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公开(公告)号：US20110206628A1
公开(公告)日：2011-08-25
申请号：US13125982
申请日：2009-10-27
摘要： The present invention provides an O/W emulsified composition which contains an organic UV absorber in an oil state such as octocrylene and a solid organic UV absorber, and is excellent in UV protection ability, formulation stability, and feeling in use. The composition according to the present invention is an O/W emulsified composition, comprising: (a) an organic UV absorber in an oil state at 20° C., comprising (a1) octocrylene; (b) an organic UV absorber in a solid state at 20° C., selected from (b1) bis-ethylhexyloxyphenol methoxyphenyl triazine and (b2) methylene bis-benzotriazolyl tetramethylbutylphenol; and (c) a polyoxyethylene/polyoxyalkylene alkyl ether block polymer represented by formula (1) or (2): R1O—(PO)m-(EO)n-H (1) wherein R1 is a hydrocarbon group having 16 to 18 carbon atoms; PO is an oxypropylene group, EU is an oxyethylene group, and PO and EO are added to each other in block form; and m and n respectively represent average addition mole number of PO and EO, 70>m>4, 70>n>10, and n>m; R2O-(AO)p-(EO)q-R3 (2) wherein R2 and R3 are either identical to or different from each other, and each of them is a hydrocarbon group having 1 to 4 carbon atoms; AO is an oxyalkylene group having 3 to 4 carbon atoms, EO is an oxyethylene group, and AO and EO are added to each other in block form; and p and q respectively represent average addition mole number of AO and EO, 1≦p≦70, 1≦q≦70, and 0.2
摘要翻译： 本发明提供一种O / W乳化组合物，其含有油状态的有机紫外线吸收剂，如辛酸和固体有机紫外线吸收剂，并且具有优异的紫外线防护能力，制剂稳定性和使用感。 根据本发明的组合物是O / W乳化组合物，其包含：（a）在20℃的油状态的有机UV吸收剂，包含（a1） （b）在20℃下为固态的有机紫外线吸收剂，选自（b1）双 - 乙基己氧基苯酚甲氧基苯基三嗪和（b2）亚甲基双苯并三唑基四甲基丁基苯酚; 和（c）由式（1）或（2）表示的聚氧乙烯/聚氧化烯烷基醚嵌段聚合物：R1O-（PO）m-（EO）n-H（1）其中R1是具有16-18个碳原子的烃基; PO是氧化亚丙基，EU是氧化乙烯基，PO和EO以嵌段形式彼此相加; m和n分别表示PO和EO的平均加成摩尔数，70> m> 4，70> n> 10，n> m; R2O-（AO）对（EO）q-R3（2）其中R2和R3彼此相同或不同，并且它们各自是具有1至4个碳原子的烃基; AO是具有3〜4个碳原子的氧化烯基，EO是氧化乙烯基，AO和EO以嵌段形式彼此相加; 和p和q分别表示AO和EO的平均加成摩尔数，1＆nlE; p＆nlE; 70,1＆nlE; q＆nlE; 70和0.2（q /（p + q））<0.8， 包含组分（a）的相是700nm或更小。
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公开(公告)号：US08691191B2
公开(公告)日：2014-04-08
申请号：US13125982
申请日：2009-10-27
摘要： The present invention provides an O/W emulsified composition which contains an organic UV absorber in an oil state such as octocrylene and a solid organic UV absorber, and is excellent in UV protection ability, formulation stability, and feeling in use. The composition according to the present invention is an O/W emulsified composition, comprising: (a) an organic UV absorber in an oil state at 20° C., comprising (a1) octocrylene; (b) an organic UV absorber in a solid state at 20° C., selected from (b1) bis-ethylhexyloxyphenol methoxyphenyl triazine and (b2) methylene bis-benzotriazolyl tetramethylbutylphenol; and (c) a polyoxyethylene/polyoxyalkylene alkyl ether block polymer represented by formula (1) or (2): R1O—(PO)m-(EO)n-H (1) wherein R1 is a hydrocarbon group having 16 to 18 carbon atoms; PO is an oxypropylene group, EU is an oxyethylene group, and PO and EO are added to each other in block form; and m and n respectively represent average addition mole number of PO and EO, 70>m>4, 70>n>10, and n>m; R2O-(AO)p-(EO)q-R3 (2) wherein R2 and R3 are either identical to or different from each other, and each of them is a hydrocarbon group having 1 to 4 carbon atoms; AO is an oxyalkylene group having 3 to 4 carbon atoms, EO is an oxyethylene group, and AO and EO are added to each other in block form; and p and q respectively represent average addition mole number of AO and EO, 1≦p≦70, 1≦q≦70, and 0.2
摘要翻译： 本发明提供一种O / W乳化组合物，其含有油状态的有机紫外线吸收剂，如辛酸和固体有机紫外线吸收剂，并且具有优异的紫外线防护能力，制剂稳定性和使用感。 根据本发明的组合物是O / W乳化组合物，其包含：（a）在20℃的油状态的有机UV吸收剂，包含（a1） （b）在20℃下为固态的有机紫外线吸收剂，选自（b1）双 - 乙基己氧基苯酚甲氧基苯基三嗪和（b2）亚甲基双苯并三唑基四甲基丁基苯酚; 和（c）由式（1）或（2）表示的聚氧乙烯/聚氧化烯烷基醚嵌段聚合物：R1O-（PO）m-（EO）n-H（1）其中R1是具有16-18个碳原子的烃基; PO是氧化亚丙基，EU是氧化乙烯基，PO和EO以嵌段形式彼此相加; m和n分别表示PO和EO的平均加成摩尔数，70> m> 4，70> n> 10，n> m; R2O-（AO）对（EO）q-R3（2）其中R2和R3彼此相同或不同，并且它们各自是具有1至4个碳原子的烃基; AO是具有3〜4个碳原子的氧化烯基，EO是氧化乙烯基，AO和EO以嵌段形式彼此相加; 和p和q分别表示AO和EO的平均加成摩尔数，1＆nlE; p＆nlE; 70,1＆nlE; q＆nlE; 70和0.2（q /（p + q））<0.8， 包含组分（a）的相是700nm或更小。
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公开(公告)号：US08425884B2
公开(公告)日：2013-04-23
申请号：US13126176
申请日：2009-10-27
申请人： Tomiko Takakura , Takafumi Kurosawa
发明人： Tomiko Takakura , Takafumi Kurosawa
IPC分类号： A61K8/00
CPC分类号： A61K8/86 , A61K8/062 , A61K8/068 , A61K8/8152 , A61K8/891 , A61K2800/21 , A61Q17/04
摘要： The present invention provides an O/W emulsified composition excellent in formulation stability, feeling in use, and UV protection ability. The emulsified composition according to the present invention is an O/W emulsified composition, wherein (i) a first oil phase and (ii) a second oil phase are dispersed separately in an aqueous phase, (i) the first oil phase having average particle size of 700 nm or less, comprising an organic UV absorber, and being formed with, as an emulsifier, a polyoxyethylene/polyoxyalkylene alkyl ether block polymer represented by formula (1) or (2): R1O—(PO)m-(EO)n-H (1) wherein R1 is a hydrocarbon group having 16 to 18 carbon atoms; PO is an oxypropylene group, EO is an oxyethylene group, and PO and EO are added to each other in block form; and m and n respectively represent average addition mole number of PO and EO, 70>m>4, 70>n>10, and n>m; and R2O-(AO)p-(EO)q-R3 (2) wherein R2 and R3 are either identical to or different from each other, and each of them is a hydrocarbon group having 1 to 4 carbon atoms; AO is an oxyalkylene group having 3 to 4 carbon atoms, EO is an oxyethylene group, and AO and EO are added to each other in block form; and p and q respectively represent average addition mole number of AO and EO, 1≦p≦70, 1≦q≦70, and 0.2
摘要翻译： 本发明提供了制剂稳定性，使用感和防紫外线性优异的O / W乳化组合物。 根据本发明的乳化组合物是O / W乳化组合物，其中（i）第一油相和（ii）第二油相分别分散在水相中，（i）第一油相具有平均颗粒 由式（1）或（2）表示的聚氧乙烯/聚氧化烯烷基醚嵌段聚合物作为乳化剂形成：含有有机紫外线吸收剂的大小为700nm以下的化合物：R1O-（PO）m-（EO ）nH（1）其中R1是具有16至18个碳原子的烃基; PO是氧化丙烯基，EO是氧化乙烯基，PO和EO以嵌段形式彼此加入; m和n分别表示PO和EO的平均加成摩尔数，70> m> 4，70> n> 10，n> m; 和R2O-（AO）对（EO）q-R3（2），其中R2和R3彼此相同或不同，并且它们各自是具有1至4个碳原子的烃基; AO是具有3〜4个碳原子的氧化烯基，EO是氧化乙烯基，AO和EO以嵌段形式彼此相加; 和p和q分别表示AO和EO的平均加成摩尔数，1≤p≤70,1≤q≤70和0.2 <（q /（p + q））<0.8，和（ii）第二油相 其包含硅油，并且形成有作为乳化剂的烷基改性的羧基乙烯基聚合物。
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公开(公告)号：US20130004553A1
公开(公告)日：2013-01-03
申请号：US13583659
申请日：2011-01-19
申请人： Tomiko Takakura , Takafumi Kurosawa , Isao Yajima
发明人： Tomiko Takakura , Takafumi Kurosawa , Isao Yajima
摘要： An O/W emulsion composition which is excellent in UV protection ability, formulation stability, and feeling in use. The O/W emulsion composition includes the following components (a) and (b): (a) organic UV absorbers comprising the following components (a1), (a2), and (a3): (a1) octocrylene, (a2) ethylhexyl methoxycinnamate, (a3) 4-t-butyl-4′-methoxydibenzoylmethane; and (b) a polyoxyethylene/polyoxyalkylene alkyl ether block polymer represented by the following formula (1) or (2); —R1O—(PO)m-(EO)n-H (1); R2O-(AO)p-(EO)q-R3 (2).
摘要翻译： 具有优异的紫外线防护能力，配方稳定性和使用感的O / W乳液组合物。 O / W乳液组合物包括以下组分（a）和（b）：（a）包含以下组分（a1），（a2）和（a3）的有机UV吸收剂：（a1）辛格林，（a2） 甲氧基肉桂酸甲酯，（a3）4-叔丁基-4'-甲氧基二苯甲酰甲烷; 和（b）由下式（1）或（2）表示的聚氧乙烯/聚氧化烯烷基醚嵌段聚合物; -R 10 - （PO）m - （EO）n -H（1）; R2O-（AO）p-（EO）q-R3（2）。
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公开(公告)号：US20110206627A1
公开(公告)日：2011-08-25
申请号：US13126176
申请日：2009-10-27
申请人： Tomiko Takakura , Takafumi Kurosawa
发明人： Tomiko Takakura , Takafumi Kurosawa
CPC分类号： A61K8/86 , A61K8/062 , A61K8/068 , A61K8/8152 , A61K8/891 , A61K2800/21 , A61Q17/04
摘要： The present invention provides an O/W emulsified composition excellent in formulation stability, feeling in use, and UV protection ability. The emulsified composition according to the present invention is an O/W emulsified composition, wherein (i) a first oil phase and (ii) a second oil phase are dispersed separately in an aqueous phase, (i) the first oil phase having average particle size of 700 nm or less, comprising an organic UV absorber, and being formed with, as an emulsifier, a polyoxyethylene/polyoxyalkylene alkyl ether block polymer represented by formula (1) or (2): R1O—(PO)m-(EO)n-H (1) wherein R1 is a hydrocarbon group having 16 to 18 carbon atoms; PO is an oxypropylene group, EO is an oxyethylene group, and PO and EO are added to each other in block form; and m and n respectively represent average addition mole number of PO and EO, 70>m>4, 70>n>10, and n>m; and R2O-(AO)p-(EO)q-R3 (2) wherein R2 and R3 are either identical to or different from each other, and each of them is a hydrocarbon group having 1 to 4 carbon atoms; AO is an oxyalkylene group having 3 to 4 carbon atoms, EO is an oxyethylene group, and AO and EO are added to each other in block form; and p and q respectively represent average addition mole number of AO and EO, 1≦p≦70, 1≦q≦70, and 0.2
摘要翻译： 本发明提供了制剂稳定性，使用感和防紫外线性优异的O / W乳化组合物。 根据本发明的乳化组合物是O / W乳化组合物，其中（i）第一油相和（ii）第二油相分别分散在水相中，（i）第一油相具有平均颗粒 由式（1）或（2）表示的聚氧乙烯/聚氧化烯烷基醚嵌段聚合物作为乳化剂形成：含有有机紫外线吸收剂的大小为700nm以下的化合物：R1O-（PO）m-（EO ）nH（1）其中R1是具有16至18个碳原子的烃基; PO是氧化丙烯基，EO是氧化乙烯基，PO和EO以嵌段形式彼此加入; m和n分别表示PO和EO的平均加成摩尔数，70> m> 4，70> n> 10，n> m; 和R2O-（AO）对（EO）q-R3（2），其中R2和R3彼此相同或不同，并且它们各自是具有1至4个碳原子的烃基; AO是具有3〜4个碳原子的氧化烯基，EO是氧化乙烯基，AO和EO以嵌段形式彼此相加; 和p和q分别表示AO和EO的平均加成摩尔数，1＆nlE; p＆nlE; 70,1＆nlE; q＆nlE; 70和0.2（q /（p + q））<0.8，和（ii）第二油相 其包含硅油，并且形成有作为乳化剂的烷基改性的羧基乙烯基聚合物。
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公开(公告)号：US20070116654A1
公开(公告)日：2007-05-24
申请号：US11638113
申请日：2006-12-13
申请人： Hirokazu Kouzuki , Morihiro Hirota , Tomoyuki Inaba , Haruhiko Inoue , Hiroshi Itagaki , Hiroyuki Kakoki , Takafumi Kurosawa
发明人： Hirokazu Kouzuki , Morihiro Hirota , Tomoyuki Inaba , Haruhiko Inoue , Hiroshi Itagaki , Hiroyuki Kakoki , Takafumi Kurosawa
IPC分类号： A61K8/37
CPC分类号： A61K9/0014 , A61K8/345 , A61K8/37 , A61K8/86 , A61K31/07 , A61K47/10 , A61K47/14 , A61K2800/75 , A61Q1/02 , A61Q1/06 , A61Q5/00 , A61Q17/04 , A61Q19/00 , A61Q19/08
摘要： The cosmetic of the present invention is a cosmetic that alleviates skin irritation by blending in polypropylene glycol, a specific polar oil, or polybutylene glycol, as well as an ultraviolet absorbent. The present invention also relates to an agent and a method for alleviating irritation by lipophilic drugs. Since the present invention alleviates skin irritation due to ultraviolet absorbents and lipophilic drugs in cosmetics, any amount of ultraviolet absorbents and lipophilic drugs can be blended in cosmetics, and therefore cosmetics that can fully manifest their effects can be provided. Also, it is possible to prepare a safe sunblock cosmetic with superior ultraviolet protection effects because the ultraviolet absorbent is not absorbed through skin.
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公开(公告)号：US20110236447A1
公开(公告)日：2011-09-29
申请号：US13132112
申请日：2009-12-03
摘要： The present invention provides an oil-in-water cosmetic excellent in emulsion stability. The oil-in-water cosmetic includes (a) oil-droplet particles consisting of an oil component to be emulsified; (b) vesicle particles for stabilizing the oil-droplet particles; and (c) an aqueous phase containing water and a monohydric aliphatic alcohol having 1 to 4 carbon atoms. It is preferred that the vesicle particles are formed with an amphiphilic substance which spontaneously forms vesicle particles, and that they are localized on surfaces of the oil-droplet particles. It is preferred that the amphiphilic substance be a polyoxyethylene hydrogenated castor oil derivative represented by the following formula (1), wherein E=L+M+N+X+Y+Z, and that said E which represents the average addition mole number of ethylene oxide is 10 to 20.
摘要翻译： 本发明提供了乳液稳定性优异的水包油化妆品。 水包油化妆品包括（a）由待乳化的油性成分组成的油滴微粒; （b）用于稳定油滴颗粒的囊泡颗粒; 和（c）含有水和含有1至4个碳原子的一元脂族醇的水相。 优选囊泡粒子由自发形成囊泡粒子的两亲性物质形成，并且它们位于油滴粒子的表面上。 优选两亲性物质是由下式（1）表示的聚氧乙烯氢化蓖麻油衍生物，其中E = L + M + N + X + Y + Z，并且所述E表示平均加成摩尔数 环氧乙烷为10〜20。
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公开(公告)号：US20070264292A1
公开(公告)日：2007-11-15
申请号：US10588916
申请日：2005-02-09
CPC分类号： A61K8/06 , A61K8/064 , A61K8/11 , A61K8/27 , A61K8/585 , A61K8/70 , A61K8/891 , A61K2800/412 , A61Q17/04
摘要： The invention is a sunscreen cosmetic containing (a) a specific hydrophobic zinc oxide powder, (b) decamethylcyclopentasiloxane, and (c) an alkyl trimethicone having 6 to 12 carbons. Hydrophobic powder that has the noticeable effects of low oil absorption and a low apparent specific volume is stably blended into a sunscreen cosmetic as a UV radiation dispersing agent to produce a sunscreen cosmetic that has remarkably improved ease of washability after use.
摘要翻译： 本发明是含有（a）特定的疏水性氧化锌粉末，（b）十甲基环五硅氧烷和（c）具有6至12个碳原子的烷基聚二甲基硅氧烷的防晒化妆品。 具有低油吸收性和低表观比体积的显着效果的疏水性粉末作为UV辐射分散剂稳定地混合到防晒化妆品中，以产生使用后显着提高易洗涤性的防晒化妆品。
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公开(公告)号：US08642018B2
公开(公告)日：2014-02-04
申请号：US10588916
申请日：2005-02-09
CPC分类号： A61K8/06 , A61K8/064 , A61K8/11 , A61K8/27 , A61K8/585 , A61K8/70 , A61K8/891 , A61K2800/412 , A61Q17/04
摘要： The invention is a sunscreen cosmetic containing (a) a specific hydrophobic zinc oxide powder, (b) decamethylcyclopentasiloxane, and (c) an alkyl trimethicone having 6 to 12 carbons.Hydrophobic powder that has the noticeable effects of low oil absorption and a low apparent specific volume is stably blended into a sunscreen cosmetic as a UV radiation dispersing agent to produce a sunscreen cosmetic that has remarkably improved ease of washability after use.
摘要翻译： 本发明是含有（a）特定的疏水性氧化锌粉末，（b）十甲基环五硅氧烷和（c）具有6至12个碳原子的烷基聚二甲基硅氧烷的防晒化妆品。 具有低油吸收性和低表观比体积的显着效果的疏水性粉末作为UV辐射分散剂稳定地混合到防晒化妆品中，以产生使用后显着提高易洗涤性的防晒化妆品。
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公开(公告)号：US20130005835A1
公开(公告)日：2013-01-03
申请号：US13576514
申请日：2011-01-24
IPC分类号： A61K8/92
CPC分类号： A61Q19/00 , A61K8/062 , A61K8/342 , A61K8/37 , A61K8/416 , A61K8/466 , A61Q17/04 , A61Q19/10
摘要： A new emulsified cosmetic composition involving α-gel, and the viscosity of the emulsified composition does not decrease over time even when salts are not added. The composition contains (A)-(E) ingredients, where (A) ingredient is a higher aliphatic alcohol, (B) ingredient is an anionic surfactant, (C) ingredient is a cationic surfactant, (D) ingredient is water, (E) ingredient is an oil component. The blend ratio of (B) ingredient is 1-15 times of the blend ratio of (C) ingredient in terms of the mole ratio.
摘要翻译： 包含α-凝胶的新的乳化化妆品组合物，即使不添加盐，乳化组合物的粘度也不会随时间降低。 组合物含有（A） - （E）成分，其中（A）成分是高级脂肪醇，（B）成分是阴离子表面活性剂，（C）成分是阳离子表面活性剂，（D）成分是水，（E ）成分是油成分。 （B）成分的混合比例为（C）成分的混合比（摩尔比）的1-15倍。
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