公开(公告)号：US11479546B2

公开(公告)日：2022-10-25

申请号：US17044550

申请日：2019-04-02

Applicant: UCB Biopharma SRL

Inventor： Teresa De Haro Garcia ,  Lloyd Malcolm King ,  Martin Alexander Lowe ,  Malcolm Maccoss ,  Richard David Taylor ,  Zhaoning Zhu

IPC: A61P33/06 ,  C07D403/12 ,  C07D493/08 ,  C07D471/04 ,  C07D239/22 ,  C07D401/12 ,  C07D413/14 ,  C07D405/06 ,  C07D405/14 ,  C07D405/04

Abstract: The application relates to a series of 2-imino-6-methylhexahydropyrimidin-4-one derivatives and 3-imino-5-methyl-1,2,4-thiadiazinane 1,1-dioxide derivatives of formula (I), substituted by an arylaminophenyl or heteroarylaminophenyl moiety. The compounds are potent inhibitors of the growth and propagation of the Plasmodium falciparum parasite in human blood and thus useful as pharmaceutical agents for the treatment of malaria.

公开(公告)号：US20210094941A1

公开(公告)日：2021-04-01

申请号：US17044550

申请日：2019-04-02

Applicant: UCB Biopharma SRL

Inventor： Teresa De Haro Garcia ,  Lloyd Malcolm King ,  Martin Alexander Lowe ,  Malcolm Maccoss ,  Richard David Taylor ,  Zhaoning Zhu

IPC: C07D405/14 ,  C07D239/22 ,  C07D405/04 ,  C07D471/04 ,  C07D413/14 ,  C07D401/12 ,  C07D403/12 ,  C07D493/08 ,  C07D405/06

Abstract: The application relates to a series of 2-imino-6-methylhexahydropyrimidin-4-one derivatives and 3-imino-5-methyl-1,2,4-thiadiazinane 1,1-dioxide derivatives of formula (I), substituted by an arylaminophenyl or heteroarylaminophenyl moiety. The compounds are potent inhibitors of the growth and propagation of the Plasmodium falciparum parasite in human blood and thus useful as pharmaceutical agents for the treatment of malaria.