公开(公告)号：US11479546B2

公开(公告)日：2022-10-25

申请号：US17044550

申请日：2019-04-02

申请人： UCB Biopharma SRL

发明人： Teresa De Haro Garcia ,  Lloyd Malcolm King ,  Martin Alexander Lowe ,  Malcolm Maccoss ,  Richard David Taylor ,  Zhaoning Zhu

IPC分类号： A61P33/06 ,  C07D403/12 ,  C07D493/08 ,  C07D471/04 ,  C07D239/22 ,  C07D401/12 ,  C07D413/14 ,  C07D405/06 ,  C07D405/14 ,  C07D405/04

摘要： The application relates to a series of 2-imino-6-methylhexahydropyrimidin-4-one derivatives and 3-imino-5-methyl-1,2,4-thiadiazinane 1,1-dioxide derivatives of formula (I), substituted by an arylaminophenyl or heteroarylaminophenyl moiety. The compounds are potent inhibitors of the growth and propagation of the Plasmodium falciparum parasite in human blood and thus useful as pharmaceutical agents for the treatment of malaria.

公开(公告)号：US20220289685A1

公开(公告)日：2022-09-15

申请号：US17632336

申请日：2020-08-17

申请人： UCB BIOPHARMA SRL

发明人： Teresa De Haro Garcia ,  Martin Alexander Lowe ,  Malcolm MacCoss ,  Richard David Taylor ,  Zhaoning Zhu ,  Rose Elizabeth Chappell

IPC分类号： C07D239/22 ,  C07D407/04 ,  C07D471/04 ,  C07D407/14 ,  A61P33/06 ,  A61K47/06

摘要： A series of 2-imino-6-methylhexahydropyrimidin-4-one derivatives, and analogues thereof, substituted in the 6-position by an arylcarbonylaminophenyl or heteroarylcarbonylaminophenyl moiety, being potent inhibitors of the growth and propagation of the Plasmodium falciparum parasite in human blood, are beneficial as pharmaceutical agents, especially in the treatment of malaria.

公开(公告)号：US20210094941A1

公开(公告)日：2021-04-01

申请号：US17044550

申请日：2019-04-02

申请人： UCB Biopharma SRL

发明人： Teresa De Haro Garcia ,  Lloyd Malcolm King ,  Martin Alexander Lowe ,  Malcolm Maccoss ,  Richard David Taylor ,  Zhaoning Zhu

IPC分类号： C07D405/14 ,  C07D239/22 ,  C07D405/04 ,  C07D471/04 ,  C07D413/14 ,  C07D401/12 ,  C07D403/12 ,  C07D493/08 ,  C07D405/06

摘要： The application relates to a series of 2-imino-6-methylhexahydropyrimidin-4-one derivatives and 3-imino-5-methyl-1,2,4-thiadiazinane 1,1-dioxide derivatives of formula (I), substituted by an arylaminophenyl or heteroarylaminophenyl moiety. The compounds are potent inhibitors of the growth and propagation of the Plasmodium falciparum parasite in human blood and thus useful as pharmaceutical agents for the treatment of malaria.

公开(公告)号：US20220242855A1

公开(公告)日：2022-08-04

申请号：US17621877

申请日：2020-06-24

申请人： UCB Biopharma SRL

发明人： Shuyu Chu ,  Helen Tracey Horsley ,  James Thomas Reuberson ,  Richard David Taylor ,  Zhaoning Zhu ,  Rose Elizabeth Chappell ,  Gregory William Haslett ,  Adam Peter Smalley ,  Nathaniel Julius Thomas Monck ,  Gareth Neil Brace ,  Prafulkumar Tulshibhai Chovatia

IPC分类号： C07D405/14 ,  C07D487/04 ,  A61K45/06 ,  A61K31/501 ,  A61K31/519 ,  A61K31/4353 ,  C07D498/04 ,  A61K31/4245 ,  A61K31/4439 ,  A61K31/497 ,  C07D417/14

摘要： A series of substituted fused bicyclic imidazole derivatives of formula (I), including benzimidazole derivatives and analogues thereof, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments including inflammatory and autoimmune disorders, wherein i. a. A represents C—R1 or N; B represents C—R2 or N; D represents C—R3 or N; E represents C—R4 or N; Z represents —CH(R5)N(H)CH2R6, —CH(R5)N(H)S(O)2R6, —C(═CR5aR5b)N(H)C(O)R6, —CH(R5)R7, —CH(R5)N(H)R7 or —CH(R5)C(O)N(H)R7; R0 represents hydrogen or C1-6 alkyl.

公开(公告)号：US20220227764A1

公开(公告)日：2022-07-21

申请号：US17614067

申请日：2020-06-24

申请人： UCB Biopharma SRL

发明人： Anne Marie Foley ,  Fabien Claude Lecomte ,  James Thomas Reuberson ,  Matthew Duncan Selby ,  Richard David Taylor ,  Paul Jonathan Hickford ,  Gareth Neil Brace

IPC分类号： C07D471/04

摘要： A series of substituted fused bicyclic imidazole derivatives, including imidazo[1,2-a]pyridine derivatives and analogues thereof, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders.

公开(公告)号：US11052076B2

公开(公告)日：2021-07-06

申请号：US16619573

申请日：2018-06-12

申请人： UCB BIOPHARMA SRL

发明人： Gareth Neil Brace ,  Rose Elizabeth Chappell ,  Hervé Jean Claude Deboves ,  Anne Marie Foley ,  Gregory Foulkes ,  Elizabeth Pearl Jones ,  Fabien Claude Lecomte ,  Joanna Rachel Quincey ,  Monika-Sarah Elisabeth Dorothea Schulze ,  Matthew Duncan Selby ,  Adam Peter Smalley ,  Richard David Taylor ,  Robert James Townsend ,  Zhaoning Zhu

IPC分类号： C07D471/10 ,  C07D487/10 ,  C07D495/10 ,  C07D491/20 ,  A61K31/4439 ,  A61K31/407 ,  A61K31/4155 ,  A61K31/4192 ,  A61K31/4196 ,  A61K31/422 ,  A61K31/427 ,  A61K31/433 ,  A61K31/437 ,  A61K31/501 ,  A61K31/502 ,  A61K31/506 ,  C07D491/107 ,  C07D519/00

摘要： A series of substituted spirocyclic 2-oxoindoline derivatives, and analogues thereof, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders.

公开(公告)号：US20210053952A1

公开(公告)日：2021-02-25

申请号：US16959339

申请日：2019-01-10

申请人： UCB Biopharma SRL

发明人： Gareth Neil Brace ,  Rose Elizabeth Chappell ,  Gregory Foulkes ,  James Richard Frost ,  Helen Tracey Horsley ,  Elizabeth Pearl Jones ,  Fabien Claude Lecomte ,  James Thomas Reuberson ,  Monika-Sarah Elizabeth Dorothea Schulze ,  Richard David Taylor ,  Wei Tsung Yau ,  Zhaoning Zhu

IPC分类号： C07D407/14 ,  C07D413/12 ,  C07D413/14 ,  C07D235/16 ,  C07D401/14

摘要： A series of substituted fused bicyclic imidazole derivatives, including benzimidazole derivatives and analogues thereof, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders.

公开(公告)号：US11472794B2

公开(公告)日：2022-10-18

申请号：US16959339

申请日：2019-01-10

申请人： UCB Biopharma SRL

发明人： Gareth Neil Brace ,  Rose Elizabeth Bardell-Cox ,  Gregory Foulkes ,  James Richard Frost ,  Helen Tracey Horsley ,  Elizabeth Pearl Jones ,  Fabien Claude Lecomte ,  James Thomas Reuberson ,  Monika-Sarah Elizabeth Dorothea Schulze ,  Richard David Taylor ,  Wei Tsung Yau ,  Zhaoning Zhu

IPC分类号： C07D403/12 ,  C07D413/12 ,  C07D407/14 ,  C07D235/16 ,  C07D401/14 ,  C07D413/14

摘要： A series of substituted fused bicyclic imidazole derivatives, including benzimidazole derivatives and analogues thereof, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders.