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公开(公告)号：US20230008089A1
公开(公告)日：2023-01-12
申请号：US17939707
申请日：2022-09-07
IPC分类号： A61K35/768 , A61K45/06 , C12N7/00
摘要： The present invention relates to oncolytic vaccinia viruses which have been modified to promote anti-tumor immunity and/or reduce host immunity and/or antibody response against the virus. It is based, at least in part, on the discovery that oncolytic vaccinia virus (i) bearing a genome deletion of a gene that reduces T cell immunity (interleukin-18 binding protein); (ii) treated with a sialidase enzyme which is believed to reduce TLR2 activation and therefore the antibody response; (iii) carrying a gene that enhances cytotoxic T lymphocyte induction (e.g., TRIF) and/or (iv) reduces tumor myeloid-derived suppressor cells by reducing prostaglandin E2 reduces tumor growth. Accordingly, the present invention provides for immunooncolytic vaccinia viruses and methods of using them in the treatment of cancers.
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公开(公告)号：US20220133825A1
公开(公告)日：2022-05-05
申请号：US17574763
申请日：2022-01-13
IPC分类号： A61K35/768 , C07K14/47 , A61K9/00 , C07K14/16 , C12N9/10 , C07K14/07 , C12N9/16 , A61P35/00 , C12N15/62 , C07K16/28
摘要： This disclosure relates to modified viruses, e.g., oncolytic vaccinia viruses, which have been modified to contain an exogenous nucleic acid that expresses a protein that modulates STAT3 activity. It is based, at least in part, on the discovery that vaccinia viruses modified to contain nucleic acid encoding PIAS3 and that express PIAS3 or a fragment thereof can inhibit STAT3 activity and enhance the anti-cancer activity of the vaccinia virus. Accordingly, this disclosure provides for oncolytic vaccinia viruses and methods of using them in the treatment of cancers.
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公开(公告)号：US11253559B2
公开(公告)日：2022-02-22
申请号：US16252338
申请日：2019-01-18
IPC分类号： A61K35/768 , A61P35/00 , A61K9/00 , C07K14/07 , C07K14/16 , C07K14/47 , C12N15/62 , C12N9/16 , C12N9/10 , C12N1/10 , C07K16/28
摘要： This disclosure relates to modified viruses, e.g., oncolytic vaccinia viruses, which have been modified to contain an exogenous nucleic acid that expresses a protein that modulates STAT3 activity. It is based, at least in part, on the discovery that vaccinia viruses modified to contain nucleic acid encoding PIAS3 and that express PIAS3 or a fragment thereof can inhibit STAT3 activity and enhance the anti-cancer activity of the vaccinia virus. Accordingly, this disclosure provides for oncolytic vaccinia viruses and methods of using them in the treatment of cancers.
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公开(公告)号：US20160235793A1
公开(公告)日：2016-08-18
申请号：US15048698
申请日：2016-02-19
IPC分类号： A61K35/768 , A61K45/06 , C12N7/00
CPC分类号： A61K35/768 , A61K39/12 , A61K45/06 , A61K2039/5256 , A61K2039/572 , A61K2039/575 , A61K2039/585 , C12N7/00 , C12N2710/24121 , C12N2710/24122 , C12N2710/24132 , C12N2710/24134 , C12N2710/24171
摘要： The present invention relates to oncolytic vaccinia viruses which have been modified to promote anti-tumor immunity and/or reduce host immunity and/or antibody response against the virus. It is based, at least in part, on the discovery that oncolytic vaccinia virus (i) bearing a genome deletion of a gene that reduces T cell immunity (interleukin-18 binding protein); (ii) treated with a sialidase enzyme which is believed to reduce TLR2 activation and therefore the antibody response; (iii) carrying a gene that enhances cytotoxic T lymphocyte induction (e.g., TRIF) and/or (iv) reduces tumor myeloid-derived suppressor cells by reducing prostaglandin E2 reduces tumor growth. Accordingly, the present invention provides for immunooncolytic vaccinia viruses and methods of using them in the treatment of cancers.
摘要翻译： 本发明涉及已被修饰以促进抗肿瘤免疫和/或降低针对病毒的宿主免疫和/或抗体应答的溶瘤性痘苗病毒。 至少部分地基于发现具有降低T细胞免疫的基因（白细胞介素-18结合蛋白）的基因组缺失的溶血性痘苗病毒（i）; （ii）用相信会降低TLR2活化并因此降低抗体应答的唾液酸酶处理; （iii）携带增强细胞毒性T淋巴细胞诱导的基因（例如TRIF）和/或（iv）通过减少前列腺素E2降低肿瘤骨髓来源的抑制细胞减少肿瘤生长。 因此，本发明提供免疫酵解痘苗病毒及其用于治疗癌症的方法。
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公开(公告)号：US11478518B2
公开(公告)日：2022-10-25
申请号：US15048698
申请日：2016-02-19
IPC分类号： A61K35/768 , A61K45/06 , C12N7/00 , A61K39/00
摘要： The present invention relates to oncolytic vaccinia viruses which have been modified to promote anti-tumor immunity and/or reduce host immunity and/or antibody response against the virus. It is based, at least in part, on the discovery that oncolytic vaccinia virus (i) bearing a genome deletion of a gene that reduces T cell immunity (interleukin-18 binding protein); (ii) treated with a sialidase enzyme which is believed to reduce TLR2 activation and therefore the antibody response; (iii) carrying a gene that enhances cytotoxic T lymphocyte induction (e.g., TRIF) and/or (iv) reduces tumor myeloid-derived suppressor cells by reducing prostaglandin E2 reduces tumor growth. Accordingly, the present invention provides for immunooncolytic vaccinia viruses and methods of using them in the treatment of cancers.
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公开(公告)号：US20220133824A1
公开(公告)日：2022-05-05
申请号：US17574691
申请日：2022-01-13
IPC分类号： A61K35/768 , A61P35/00 , C12N9/16 , C07K14/16 , C12N9/10 , A61K9/00 , C07K14/07 , C12N15/62 , C07K14/47 , C07K16/28
摘要： This disclosure relates to modified viruses, e.g., oncolytic vaccinia viruses, which have been modified to contain an exogenous nucleic acid that expresses a protein that modulates STAT3 activity. It is based, at least in part, on the discovery that vaccinia viruses modified to contain nucleic acid encoding PIAS3 and that express PIAS3 or a fragment thereof can inhibit STAT3 activity and enhance the anti-cancer activity of the vaccinia virus. Accordingly, this disclosure provides for oncolytic vaccinia viruses and methods of using them in the treatment of cancers.
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公开(公告)号：US20190142883A1
公开(公告)日：2019-05-16
申请号：US16252338
申请日：2019-01-18
摘要： This disclosure relates to modified viruses, e.g., oncolytic vaccinia viruses, which have been modified to contain an exogenous nucleic acid that expresses a protein that modulates STAT3 activity. It is based, at least in part, on the discovery that vaccinia viruses modified to contain nucleic acid encoding PIAS3 and that express PIAS3 or a fragment thereof can inhibit STAT3 activity and enhance the anti-cancer activity of the vaccinia virus. Accordingly, this disclosure provides for oncolytic vaccinia viruses and methods of using them in the treatment of cancers.
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