公开(公告)号：US20210338891A1

公开(公告)日：2021-11-04

申请号：US17370101

申请日：2021-07-08

Applicant: UNIVERSITY OF SOUTH CAROLINA

Inventor： DOMINIC M. CASALI ,  MICHAEL A. MATTHEWS

IPC: A61L27/36

Abstract: A system and method for decellularizing tissue is provided. The system includes a pretreatment chamber including a pretreatment solution (e.g., a surfactant), a decellularization solution comprising carbon dioxide and one or more polar solvents, as well as an environmental chamber comprising a treatment chamber. The environmental chamber is maintained at a temperature greater than 31.1° C. and the carbon dioxide is maintained at a pressure greater than 7.38 megapascals to form supercritical CO2. Tissue treated with the decellularization system and method can contain less than 0.05 micrograms of DNA per milligram of dry tissue after the tissue is exposed to the decellularization solution for a time period ranging from about 1 minute to about 2 hours with minimal ECM fiber disruption. A two-part decellularization solution comprising a surfactant as well as supercritical CO2 and one or more polar solvents is also provided.

公开(公告)号：US20230112486A1

公开(公告)日：2023-04-13

申请号：US17953593

申请日：2022-09-27

Applicant: UNIVERSITY OF SOUTH CAROLINA

Inventor： BIPLAV SRIVASTAVA ,  TARMO KOPPEL ,  MICHAEL N. HUHNS ,  MICHAEL A. MATTHEWS ,  PAUL ZIEHL ,  DANIELLE MCELWAIN

IPC: G06Q10/06 ,  G06Q10/10

Abstract: The disclosure deals with a system and method for building teams in response to a teaming opportunity. In one exemplary embodiment disclosed herewith, a system and method for building teams for Request for Proposals (RFPs) is described where potential team participants are researchers at one or more institutions. A computer-based method and computer system, given RFPs from funding agencies like NSF, DOE and NASA, recommends a team of experts from various faculties and departments of the organization, like a university, that would best fit the needs of the RFP and have a high chance of putting a successful proposal together. The system generates teams that may match the requirements of an RFP. In addition, the system optimizes the list of teams to maximize winning success and to reduce redundancy. The system input includes RFPs and the researchers' public information. The system output is a list of proposed teams, each team with two or more members. Optionally, each team will have an estimation of the team's budget and proposal success chances. The disclosed methodology is more broadly applicable to team-building opportunities in general.