公开(公告)号：US12252490B2

公开(公告)日：2025-03-18

申请号：US17265883

申请日：2019-08-08

Applicant: Valo Health, Inc.

Inventor： David J. Guerin ,  Justin A. Caravella ,  Hongbin Li ,  Steven Mischke ,  David J. Richard ,  Shawn E. R. Schiller ,  Tatiana Shelekhin

IPC: C07D487/04 ,  A61P35/00 ,  C07D471/04 ,  C07D487/08 ,  C07D519/00

Abstract: The present disclosure relates to modulators, such as inhibitors, of at least one pathway chosen from USP28 and USP25, pharmaceutical compositions comprising the inhibitors, and methods of using the inhibitors. The modulators, such as inhibitors, of at least one pathway chosen from USP28 and USP25 can be useful in the treatment of cancers, among other ailments. The present disclosure provides compounds of Formula (I).

公开(公告)号：US11325917B2

公开(公告)日：2022-05-10

申请号：US17003356

申请日：2020-08-26

Applicant: Valo Health, Inc.

Inventor： David Joseph Guerin ,  Kenneth W. Bair ,  Justin A. Caravella ,  Stephanos Ioannidis ,  David R. Lancia, Jr. ,  Hongbin Li ,  Steven Mischke ,  Pui Yee Ng ,  David Richard ,  Shawn E. R. Schiller ,  Tatiana Shelekhin ,  Zhongguo Wang

IPC: C07D495/04

Abstract: The disclosure relates to inhibitors of USP28 and/or USP25 useful in the treatment of cancers, inflammation, autoimmune diseases, and infectious diseases, having the Formula: (I), where R1, R2, R3, R4, R4′, R5, R6, X, and n are described herein.