公开(公告)号：US11325917B2

公开(公告)日：2022-05-10

申请号：US17003356

申请日：2020-08-26

Applicant: Valo Health, Inc.

Inventor： David Joseph Guerin ,  Kenneth W. Bair ,  Justin A. Caravella ,  Stephanos Ioannidis ,  David R. Lancia, Jr. ,  Hongbin Li ,  Steven Mischke ,  Pui Yee Ng ,  David Richard ,  Shawn E. R. Schiller ,  Tatiana Shelekhin ,  Zhongguo Wang

IPC: C07D495/04

Abstract: The disclosure relates to inhibitors of USP28 and/or USP25 useful in the treatment of cancers, inflammation, autoimmune diseases, and infectious diseases, having the Formula: (I), where R1, R2, R3, R4, R4′, R5, R6, X, and n are described herein.

公开(公告)号：US12018030B2

公开(公告)日：2024-06-25

申请号：US17186915

申请日：2021-02-26

Applicant: Valo Health, Inc.

Inventor： Stephanos Ioannidis ,  Adam Charles Talbot ,  Bruce Follows ,  Alexandre Joseph Buckmelter ,  Minghua Wang ,  Ann-Marie Campbell ,  Darby Rye Schmidt ,  David Joseph Guerin ,  Justin Andrew Caravella ,  R. Bruce Diebold ,  Anna Ericsson ,  David R. Lancia, Jr.

IPC: C07D487/04 ,  A61K31/519 ,  C07D519/00

CPC classification number: C07D487/04 ,  A61K31/519 ,  C07D519/00

Abstract: The invention relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula:




where m, n, X1, X2, R1-R5, R5′ and R6 are described herein.