Patent search ap:("Vanderbilt University") AND inv:"Somnath Jana" Page 1

1.

发明申请
SMALL MOLECULE INHIBITORS OF LACTATE DEHYDROGENASE AND METHODS OF USE THEREOF 审中-公开

公开(公告)号：US20180273488A1

公开(公告)日：2018-09-27

申请号：US15540893

申请日：2015-12-29

Applicant: VANDERBILT UNIVERSITY , The UAB Research Foundation , The Trustees of the University of Pennsylvania , THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HE

Inventor： David J. Maloney , Alex Gregory Waterson , Ganesh Rai Bantukallu , Kyle Ryan Brimacombe , Plamen Christov , Chi V. Dang , Victor Darley-Usmar , Xin Hu , Ajit Jadhav , Somnath Jana , Kwangho Kim , Jennifer L. Kouznetsova , William J. Moore , Bryan T. Mott , Leonard M. Neckers , Anton Simeonov , Gary Allen Sulikowski , Daniel Jason Urban , Shyh Ming Yang

IPC: C07D231/20 , A61K45/06 , C07D417/04 , A61K31/427 , C07D471/04 , A61K31/437 , A61K31/5355 , C07D417/14 , C07D495/04 , A61K31/519 , C07D403/04 , A61K31/4178 , C07D409/04 , A61K31/4155 , A61K31/4439 , A61K31/415 , A61K31/496 , C07D495/14 , A61K31/501 , C07D231/38 , C07D403/06 , C07D401/04 , C07D413/04 , A61K31/422 , A61K31/506 , A61K31/454

CPC classification number: C07D231/20 , A61K31/415 , A61K31/4155 , A61K31/4178 , A61K31/422 , A61K31/427 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/501 , A61K31/506 , A61K31/519 , A61K31/5355 , A61K45/06 , C07D231/38 , C07D401/04 , C07D403/04 , C07D403/06 , C07D409/04 , C07D413/04 , C07D417/04 , C07D417/14 , C07D471/04 , C07D495/04 , C07D495/14

Abstract: Provided is a compound of formula (I) [Formula (I) should be inserted here], in which Ar1, R1, U, V, W, X, and p are as described herein. Also provided are methods of using a compound of formula (I), including a method of treating cancer, a method of treating a patient with cancer cells resistant to an anti-cancer agent, and a method of inhibiting lactate dehydrogenase A (LDHA) and/or lactate dehydrogenase B (LDHB) activity in a cell.

2.

发明申请
TASPASE1 INHIBITORS AND USES THEREOF 有权

公开(公告)号：US20230052528A1

公开(公告)日：2023-02-16

申请号：US17777971

申请日：2020-11-20

Applicant: The Regents of the University of California , WASHINGTON UNIVERSITY IN ST. LOUIS , VANDERBILT UNIVERSITY , SRI INTERNATIONAL , The United States of America, as represented by the Secretary, Department of Health and Human Servic

Inventor： Michelle R. Arkin , R. Jeffrey Neitz , Adam R. Renslo , James Hsieh , Shubhankar Dutta , Clifford Bryant , William J. Moore , Alex G. Waterson , Lidia Sambucetti , Somnath Jana , lan M. Romaine , Alexander P. Lamers , Yassir Younis Adam , Claire Repellin

IPC: C07D241/04 , A61P35/00 , A61P11/00 , C07C311/11 , C07D295/26 , C07D403/12 , C07C323/41 , C12N9/64

Abstract: Disclosed herein, inter alia, are compounds and methods for inhibiting Taspase1 and the treatment of cancer.

3.

发明授权
1 H-pyrazol-1-yl-thiazoles as inhibitors of lactate dehydrogenase and methods of use thereof 有权

公开(公告)号：US10954228B2

公开(公告)日：2021-03-23

申请号：US16313727

申请日：2017-06-29

Applicant: NATIONAL INSTITUTES OF HEALTH, UNITED STATES DEPARTMENT OF HEALTH AND HUMAN SERVICES , Vanderbilt University , The UAB Research Foundation , The Trustees of the University of Pennsylvania

Inventor： David J. Maloney , Alex Gregory Waterson , Ganesha Rai Bantukallu , Kyle Ryan Brimacombe , Plamen Christov , Chi V. Dang , Victor M. Darley-Usmar , Matthew Hall , Xin Hu , Ajit Jadhav , Somnath Jana , Kwangho Kim , William J. Moore , Bryan T. Mott , Leonard M. Neckers , Anton Simeonov , Gary Allen Sulikowski , Daniel Jason Urban , Shyh Ming Yang

IPC: C07D417/04 , C07D417/14 , A61P11/00 , A61P35/00

Abstract: The disclosure provides a compound of the formula (II) and pharmaceutically acceptable salts thereof. The variables, e.g. n, R, R3, R10, X, Y, and Z are defined herein. These compounds act as lactate dehydrogenase inhibitors and are useful for treating cancer and fibrosis. The compounds may be particularly useful for treating forms of cancer in which a metabolic switch from oxidative phosphorylation to glycolysis has occurred. The disclosure also provides pharmaceutical compositions containing a compound of this formula and method for treating patients having cancer, fibrosis, or other conditions in which a metabolic switch from oxidative phosphorylation to glycolysis has occurred.

4.

发明授权
Small molecule inhibitors of lactate dehydrogenase and methods of use thereof 有权

公开(公告)号：US10351532B2

公开(公告)日：2019-07-16

申请号：US15540893

申请日：2015-12-29

Applicant: THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HE , VANDERBILT UNIVERSITY , The UAB Research Foundation , The Trustees of the University of Pennsylvania

Inventor： David J. Maloney , Alex Gregory Waterson , Ganesh Rai Bantukallu , Kyle Ryan Brimacombe , Plamen Christov , Chi V. Dang , Victor Darley-Usmar , Xin Hu , Ajit Jadhav , Somnath Jana , Kwangho Kim , Jennifer L. Kouznetsova , William J. Moore , Bryan T. Mott , Leonard M. Neckers , Anton Simeonov , Gary Allen Sulikowski , Daniel Jason Urban , Shyh Ming Yang

IPC: C07D231/20 , C07D231/38 , C07D401/04 , C07D403/04 , C07D403/06 , C07D409/04 , C07D413/04 , C07D417/04 , C07D417/14 , C07D471/04 , C07D495/04 , C07D495/14 , A61K31/4155 , A61K31/4178 , A61K31/422 , A61K31/427 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/501 , A61K31/506 , A61K31/519 , A61K31/5355 , A61K31/415 , A61K45/06

Abstract: Provided is a compound of formula (I), in which Ar1, R1, U, V, W, X, and p are as described herein. Also provided are methods of using a compound of formula (I), including a method of treating cancer, a method of treating a patient with cancer cells resistant to an anti-cancer agent, and a method of inhibiting lactate dehydrogenase A (LDHA) and/or lactate dehydrogenase B (LDHB) activity in a cell.

5.

发明授权
Small molecule inhibitors of lactate dehydrogenase and methods of use thereof 有权

公开(公告)号：US11897845B2

公开(公告)日：2024-02-13

申请号：US17572359

申请日：2022-01-10

Applicant: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , VANDERBILT UNIVERSITY , The UAB Research Foundation , The Trustees of the University of Pennsylvania

Inventor： David J. Maloney , Alex Gregory Waterson , Ganesh Rai Bantukallu , Kyle Ryan Brimacombe , Plamen Christov , Chi V. Dang , Victor Darley-Usmar , Xin Hu , Ajit Jadhav , Somnath Jana , Kwangho Kim , Jennifer L. Kouznetsova , William J. Moore , Bryan T. Mott , Leonard M. Neckers , Anton Simeonov , Gary Allen Sulikowski , Daniel Jason Urban , Shyh Ming Yang

IPC: C07D231/20 , C07D231/38 , C07D401/04 , C07D403/04 , C07D403/06 , C07D409/04 , C07D413/04 , C07D417/04 , C07D417/14 , C07D471/04 , C07D495/04 , C07D495/14 , A61K31/415 , A61K31/4155 , A61K31/422 , A61K31/427 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/501 , A61K31/506 , A61K31/519 , A61K31/5355 , A61K45/06 , A61K31/4178

CPC classification number: C07D231/20 , A61K31/415 , A61K31/4155 , A61K31/4178 , A61K31/422 , A61K31/427 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/501 , A61K31/506 , A61K31/519 , A61K31/5355 , A61K45/06 , C07D231/38 , C07D401/04 , C07D403/04 , C07D403/06 , C07D409/04 , C07D413/04 , C07D417/04 , C07D417/14 , C07D471/04 , C07D495/04 , C07D495/14

Abstract: Provided is a compound of formula (I)

in which Ar1, R1, U, V, W, X, and p are as described herein. Also provided are methods of using a compound of formula (I), including a method of treating cancer, a method of treating a patient with cancer cells resistant to an anti-cancer agent, and a method of inhibiting lactate dehydrogenase A (LDHA) and/or lactate dehydrogenase B (LDHB) activity in a cell.

6.

发明申请
CHRYSOPHAENTIN ANALOGS AND USE THEREOF 有权

公开(公告)号：US20220144794A1

公开(公告)日：2022-05-12

申请号：US17602133

申请日：2020-04-09

Applicant: Vanderbilt University

Inventor： Gary A. Sulikowski , Christopher Fullenkamp , Kwangho Kim , Somnath Jana

IPC: C07D321/00 , A61P31/04

Abstract: Provided are 9-dechlorochrysophaentin analog compounds and the synthesis process thereof. The disclosed compound have remarkable antimicrobial activities that are comparable to, or even more potent than, the natural product chrysophaentin A. Also provided are method of inhibiting bacterial growth or treating bacterial infection by administering an effective amount of the disclosed compounds.