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公开(公告)号：US20060035297A1
公开(公告)日：2006-02-16
申请号：US11201992
申请日：2005-08-11
申请人： Vani Bodepudi , Amy Tsai , Weixing Luo , Rueyming Loor
发明人： Vani Bodepudi , Amy Tsai , Weixing Luo , Rueyming Loor
CPC分类号： G01N33/9493 , C07K16/44
摘要： The invention teaches derivatives of mycophenolic alcohol and methods of preparing immunogens and other conjugates useful in immunoassays for quantitatively measuring concentrations of mycophenolic acid (MPA) and/or active metabolites of MPA in patient specimens. Antibodies produced from the disclosed immunogens capable of binding to MPA with cross-reactivity of no more than 5% with inactive metabolites and commonly co-prescribed drugs. Further, immunoassays for measuring the concentration of MPA using such antibodies are taught.
摘要翻译： 本发明教导霉酚醇的衍生物和制备用于免疫测定的免疫原和其它缀合物的方法，用于定量测量患者标本中的MPA和/或MPA的活性代谢物的浓度。 从所公开的能够与MPA结合的免疫原产生的抗体产生的交联反应性不超过5％，与无活性代谢物和通常共同处方的药物。 此外，教导了使用这种抗体测量MPA浓度的免疫测定。
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公开(公告)号：US08071546B2
公开(公告)日：2011-12-06
申请号：US11921689
申请日：2006-06-09
CPC分类号： A61K38/38 , A61K9/0019
摘要： The present invention is directed to uses of PEGylated albumins which include methods of treating reduced functional capillary density, reduced blood volume, septic shock and cardiac arrhythmia in a subject, which comprise administering to the subject a therapeutically effective amount of a PEGylated albumin.
摘要翻译： 本发明涉及聚乙二醇化蛋白质的用途，其包括治疗受试者中功能性毛细血管密度降低，血液体积减少，败血性休克和心律失常的方法，其包括向受试者施用治疗有效量的聚乙二醇化白蛋白。
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公开(公告)号：US20100222260A1
公开(公告)日：2010-09-02
申请号：US11921689
申请日：2006-06-09
CPC分类号： A61K38/38 , A61K9/0019
摘要： The present invention is directed to uses of PEGylated albumins which include methods of treating reduced functional capillary density, reduced blood volume, septic shock and cardiac arrhythmia in a subject, which comprise administering to the subject a therapeutically effective amount of a PEGylated albumin.
摘要翻译： 本发明涉及聚乙二醇化白蛋白的用途，其包括治疗受试者中功能性毛细血管密度降低，血液体积减少，败血性休克和心律失常的方法，其包括向受试者施用治疗有效量的聚乙二醇化白蛋白。
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