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1.发明申请公开(公告)号：US20090305951A1
公开(公告)日：2009-12-10
申请号：US12435043
申请日：2009-05-04
CPC分类号： C07K14/70503 , A61K38/00 , C07K2319/00
摘要： The present invention relates to a compound comprising the third Immunoglobulin (Ig3) module, and/or the fourth Immunoglobulin (Ig4) module, and/or the fifth immunoglobulin (Ig5) module, and/or the first Fibronectin III (Fn3,1) module, and/or the second Fibronectin III (Fn3,2) module of neural cell adhesion molecule (NCAM), or a fragment, or a variant thereof, capable of interacting with an Fibroblast Growth Factor (FGF) receptor and/or Adenosine-Tri-Phosphate (ATP) and/or L1, and thereby the compounds are capable of inducing differentiation, modulating proliferation, stimulate regeneration, neuronal plasticity and/or survival of cells. Further, the present invention relates to a pharmaceutical composition comprising said compound, a process of producing a pharmaceutical composition and the use of said compound.
摘要翻译： 本发明涉及包含第三免疫球蛋白（Ig3）模块和/或第四免疫球蛋白（Ig4）模块和/或第五免疫球蛋白（Ig5）模块和/或第一纤连蛋白III（Fn3,1） 模块和/或能够与成纤维细胞生长因子（FGF）受体和/或腺苷 - 丝氨酸蛋白酶相互作用的神经细胞粘附分子（NCAM）的第二纤连蛋白III（Fn3,2）模块或其片段或其变体， 三磷酸盐（ATP）和/或L1，因此化合物能够诱导分化，调节增殖，刺激再生，神经元可塑性和/或细胞存活。 此外，本发明涉及包含所述化合物的药物组合物，制备药物组合物的方法和所述化合物的用途。
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2.发明授权Compounds capable of affecting differentiation, proliferation, regeneration, plasticity and survival cells 有权能够影响分化，增殖，再生，可塑性和存活细胞的化合物公开(公告)号：US08071549B2
公开(公告)日：2011-12-06
申请号：US12435043
申请日：2009-05-04
IPC分类号： A61K38/00 , C07K14/78 , C07K14/705
CPC分类号： C07K14/70503 , A61K38/00 , C07K2319/00
摘要： The present invention relates to a compound comprising the third Immunoglobulin (Ig3) module, and/or the fourth Immunoglobulin (Ig4) module, and/or the fifth immunoglobulin (Ig5) module, and/or the first Fibronectin III (Fn3,1) module, and/or the second Fibronectin III (Fn3,2) module of neural cell adhesion molecule (NCAM), or a fragment, or a variant thereof, capable of interacting with an Fibroblast Growth Factor (FGF) receptor and/or Adenosine-Tri-Phosphate (ATP) and/or L1, and thereby the compounds are capable of inducing differentiation, modulating proliferation, stimulate regeneration, neuronal plasticity and/or survival of cells. Further, the present invention relates to a pharmaceutical composition comprising said compound, a process of producing a pharmaceutical composition and the use of said compound.
摘要翻译： 本发明涉及包含第三免疫球蛋白（Ig3）模块和/或第四免疫球蛋白（Ig4）模块和/或第五免疫球蛋白（Ig5）模块和/或第一纤连蛋白III（Fn3,1） 模块和/或能够与成纤维细胞生长因子（FGF）受体和/或腺苷 - 丝氨酸蛋白酶相互作用的神经细胞粘附分子（NCAM）的第二纤连蛋白III（Fn3,2）模块或其片段或其变体， 三磷酸盐（ATP）和/或L1，因此化合物能够诱导分化，调节增殖，刺激再生，神经元可塑性和/或细胞存活。 此外，本发明涉及包含所述化合物的药物组合物，制备药物组合物的方法和所述化合物的用途。
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