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公开(公告)号：US20230192850A1
公开(公告)日：2023-06-22
申请号：US17816732
申请日：2022-08-02
CPC分类号： C07K16/2809 , A61K47/6803 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/565 , C07K2317/567 , C07K2317/77 , C07K2317/92
摘要： The present disclosure provides isolated monoclonal anti-CD3epsilon antibodies or antigen-binding fragments thereof comprising one or more heavy chain CDR sequences selected from the group consisting of: SEQ ID NOs: 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, 35, 37, 39, 41, 43, 45, and 47, and/or one or more kappa light chain CDR sequences selected from the group consisting of: SEQ ID NOs: 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 46 and 48, isolated polynucleotides encoding the same, pharmaceutical compositions comprising the same, and the use thereof.
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公开(公告)号：US20200283523A1
公开(公告)日：2020-09-10
申请号：US16648792
申请日：2018-09-20
发明人： Jieying LIU , Jianqing XU , Zhuozhi WANG , Qin MEI , Jing LI
摘要： A bispecific anti-CD3×CD19 polypeptide complex that contains a first antigen-binding moiety of the polypeptide complex and a second antigen-binding moiety, methods of producing the bispecific anti-CD3×CD19 polypeptide complex, methods of treating disease or disorder using the bispecific anti-CD3×CD19 polypeptide complex, polynucleotides encoding the bispecific anti-CD3×CD19 polypeptide complex, vectors and host cells containing said polynucleotides, and compositions and pharmaceutical compositions comprising the bispecific anti-CD3×CD19 polypeptide complex are provided.
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公开(公告)号：US20210380710A1
公开(公告)日：2021-12-09
申请号：US17057607
申请日：2019-05-29
发明人： Yunying CHEN , Qin MEI , Zhuozhi WANG , Jing LI
摘要： Provided are a bispecific antibody comprising a first antigen-binding site that specifically binds to CD3 and a second antigen-binding site that specifically binds to an antigen different from CD3. It also provides the method for producing the bispecific antibody, and the use thereof.
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公开(公告)号：US20200299384A1
公开(公告)日：2020-09-24
申请号：US16649149
申请日：2018-09-20
摘要： The present disclosure provides isolated monoclonal anti-CD3epsilon antibodies or antigen-binding fragments thereof comprising one or more heavy chain CDR sequences selected from the group consisting of: SEQ ID NOs: 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, 35, 37, 39, 41, 43, 45, and 47, and/or one or more kappa light chain CDR sequences selected from the group consisting of: SEQ ID NOs: 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 46 and 48, isolated polynucleotides encoding the same, pharmaceutical compositions comprising the same, and the use thereof.
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公开(公告)号：US20230203159A1
公开(公告)日：2023-06-29
申请号：US17816731
申请日：2022-08-02
CPC分类号： C07K16/2809 , C07K16/30 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/77 , C07K2317/92
摘要： The present disclosure provides isolated monoclonal anti-CD3epsilon antibodies or antigen-binding fragments thereof comprising one or more heavy chain CDR sequences selected from the group consisting of: SEQ ID NOs: 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, 35, 37, 39, 41, 43, 45, and 47, and/or one or more kappa light chain CDR sequences selected from the group consisting of: SEQ ID NOs: 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 46 and 48, isolated polynucleotides encoding the same, pharmaceutical compositions comprising the same, and the use thereof.
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公开(公告)号：US20230008090A1
公开(公告)日：2023-01-12
申请号：US17777596
申请日：2020-11-27
发明人： Qin MEI , Zhuozhi WANG , Jing LI , Jianqing XU
摘要： Provided are bispecific antibodies against CD3 and EGFR, the nucleic acid molecules encoding the antibodies, expression vectors and host cells used for the expression of the antibodies. The antibodies provide a potent agent for the treatment of CD3-related and/or EGFR-related diseases via modulating immune functions.
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公开(公告)号：US20220403023A1
公开(公告)日：2022-12-22
申请号：US17770039
申请日：2020-10-23
发明人： Qin MEI , Fagen HU , Jing LI , Jiaxiang SHAO , Yuhong SHEN
IPC分类号： C07K16/28 , A61P35/00 , A61K39/395 , A61K45/06
摘要： Provided are anti-CD47 antibodies, the nucleic acid molecules encoding the anti-CD47 antibodies, expression vectors and host cells used for the expression of anti-CD47 antibodies. Provided are methods for validating the function of antibodies. The antibodies provide a potent agent for the treatment of cancers via modulating immune functions.
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公开(公告)号：US20220162312A1
公开(公告)日：2022-05-26
申请号：US17425870
申请日：2020-01-22
发明人： Yunying CHEN , Qin MEI , Jianqing XU , Zhuozhi WANG , Jing LI
IPC分类号： C07K16/28 , A61P35/00 , C07K14/725 , C07K14/705
摘要： The present disclosure provides a bispecific anti-CD3×CD20 polypeptide complex that contains a first antigen-binding moiety of the polypeptide complex and a second antigen-binding moiety, methods of producing the bispecific anti-CD3×CD20 polypeptide complex, methods of treating disease or disorder using the bispecific anti-CD3×CD20 polypeptide complex, polynucleotides encoding the bispecific anti-CD3×CD20 polypeptide complex, vectors and host cells containing said polynucleotides, and compositions and pharmaceutical compositions comprising the bispecific anti-CD3×CD20 polypeptide complex.
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