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公开(公告)号：US20240301067A1
公开(公告)日：2024-09-12
申请号：US18674733
申请日：2024-05-24
发明人： Yunying CHEN , Jing LI
IPC分类号： C07K16/28
CPC分类号： C07K16/2818 , C07K2317/24 , C07K2317/33 , C07K2317/569 , C07K2317/732 , C07K2317/76 , C07K2317/92
摘要： The present invention provides novel anti-PD-1 antibodies that specifically bind to cell surface PD-1. Also provided are the nucleic acid molecules encoding the anti-PD-1 antibodies, expression vectors and host cells used for the expression of the anti-PD-1 antibodies. The invention further provides the methods for producing the anti-PD-1 antibodies and the use thereof.
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公开(公告)号：US12030941B2
公开(公告)日：2024-07-09
申请号：US16981336
申请日：2019-03-18
发明人： Yunying Chen , Jing Li
IPC分类号： C07K16/28
CPC分类号： C07K16/2818 , C07K2317/24 , C07K2317/33 , C07K2317/569 , C07K2317/732 , C07K2317/76 , C07K2317/92
摘要： The present invention provides novel anti-PD-1 antibodies that specifically bind to cell surface PD-1. Also provided are the nucleic acid molecules encoding the anti-PD-1 antibodies, expression vectors and host cells used for the expression of the anti-PD-1 antibodies. The invention further provides the methods for producing the anti-PD-1 antibodies and the use thereof.
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公开(公告)号：US20240158734A1
公开(公告)日：2024-05-16
申请号：US18284759
申请日：2021-12-07
发明人： Hao Chen , Kee Wee Tan , Jie Ding
摘要： The present application belongs to the technical field of biopharmaceutical production devices, and discloses a culture vessel carrier automatic slide mechanism and a shaker incubator, by means of which a shake flask/shake tube/well plate carrier assembly can automatically slide in and out relative to an incubator main body. The culture vessel carrier automatic slide mechanism comprises a slide protective housing and is provided with a culture vessel carrier bearing member. A first slide rail and a second slide rail are arranged below the culture vessel carrier bearing member. The second slide rail is arranged below the culture vessel carrier bearing member and located above the first slide rail, and the first slide rail is arranged inside the incubator main body on a fixed base that does not slide. An intermediate slide rail fixing plate secured to an inner wall of the slide protective housing is connected between the first slide rail and the second slide rail, and a sliding channel is provided on each side of the intermediate slide rail fixing plate. During sliding out and in, the sliding channels on the intermediate slide rail fixing plate can synchronously slide with the second slide rail, and the second slide rail can slide relative to the intermediate slide rail fixing plate, so as to achieve two-stage sliding of a bearing tray of the shake flask/shake tube/well plate carrier assembly arranged on the slide protective housing.
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4.发明公开公开(公告)号：US20230287378A1
公开(公告)日：2023-09-14
申请号：US17996441
申请日：2021-04-21
发明人： Liqin XU , Fenglin WANG , Yangfang ZHOU , Yangzi PENG , Jiexing CAI , Weichang ZHOU , Xiaobo XI , Weiwen WANG , Tingting WANG , Chunsheng YANG , Quanmin CHEN , Jeremy GUO
CPC分类号： C12N9/2402 , A61K38/47 , C12N9/1051 , C12N15/907 , C12Y204/01101 , C12Y302/01045 , C12N2310/20
摘要： Provided are a genetically modified cell line producing a recombinant glycoprotein having a mannose-terminated N-glycan and a method for producing the recombinant glycoprotein or a method for generating the cell, clone or cell line. The cell line comprises an insertion of less than 600 bp in the coding region of a chromosomal sequence encoding MGAT1.
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公开(公告)号：US11661452B2
公开(公告)日：2023-05-30
申请号：US16982605
申请日：2019-03-15
申请人： WUXI BIOLOGICS IRELAND LIMITED , CSTONE PHARMACEUTICALS , CSTONE PHARMACEUTICALS (SUZHOU) CO., LTD. , CSTONE PHARMACEUTICALS (SHANGHAI) CO., LTD.
发明人： Yunying Chen , Jing Li
IPC分类号： A61K39/395 , A61K39/00 , C12Q1/68 , C12N5/02 , C12N1/20 , C12N15/00 , C07K16/00 , C07K16/46 , C07H21/04 , C07K16/28 , G01N33/68
CPC分类号： C07K16/2803 , G01N33/68 , A61K2039/505 , C07K2317/22 , C07K2317/24 , C07K2317/33 , C07K2317/565 , C07K2317/569 , C07K2317/732 , C07K2317/76 , C07K2317/92 , G01N2333/70503
摘要： The present disclosure provides anti-LAG-3 heavy-chain antibody or the antigen-binding domain thereof, isolated polynucleotides encoding the same, pharmaceutical compositions comprising the same, and the uses thereof.
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公开(公告)号：US20230072133A1
公开(公告)日：2023-03-09
申请号：US17800197
申请日：2021-02-24
发明人： Yunying CHEN , Jing LI , Jijie GU
摘要： The present disclosure provides a fusion protein comprising at least a portion of TGFβRII and anti-PD-L1 antibody or antigen-binding portion thereof, methods of producing the fusion protein, methods of treating diseases or conditions using the fusion protein, and uses thereof.
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公开(公告)号：US11365254B2
公开(公告)日：2022-06-21
申请号：US16648792
申请日：2018-09-20
发明人： Jieying Liu , Jianqing Xu , Zhuozhi Wang , Qin Mei , Jing Li
摘要： A bispecific anti-CD3×CD19 polypeptide complex that contains a first antigen-binding moiety of the polypeptide complex and a second antigen-binding moiety, methods of producing the bispecific anti-CD3×CD19 polypeptide complex, methods of treating disease or disorder using the bispecific anti-CD3×CD19 polypeptide complex, polynucleotides encoding the bispecific anti-CD3×CD19 polypeptide complex, vectors and host cells containing said polynucleotides, and compositions and pharmaceutical compositions comprising the bispecific anti-CD3×CD19 polypeptide complex are provided.
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公开(公告)号：US20210380638A1
公开(公告)日：2021-12-09
申请号：US17416391
申请日：2019-12-20
发明人： Yifeng LI , Ying WANG , Yuan ZHANG , Weichang ZHOU
摘要： Protein A chromatography is generally less effective in removing antibody aggregates under typical conditions. Provided is a combination and a method that can significantly improve Protein A's aggregate removal capability. The combination comprises polyethylene glycol (PEG) and a salt (chaotropic or kosmotropic) as wash and elution buffer additives. The synergistic effect of salt and PEG results in almost complete separation of monomer from aggregates. For the case used for demonstration, in comparison with the control run the optimized procedure reduces aggregates in elution pool from 20% to 3-4%. This new method, by facilitating aggregate removal at the capture step, improves the overall robustness of downstream process.
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公开(公告)号：US10981995B2
公开(公告)日：2021-04-20
申请号：US15749783
申请日：2016-08-05
发明人： Yong Zheng , Jing Li , Zhisheng Chen
摘要： The present disclosure provides monoclonal antibodies against protein programmed cell death 1 ligand (PD-L1), which can block the binding of PD-L1 to PD-1, and therefore block the inhibitory function of PD-L1 on PD-1 expressing T cells. The antibodies of disclosure provide very potent agents for the treatment of multiple cancers via modulating human immune function.
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公开(公告)号：US20210061912A1
公开(公告)日：2021-03-04
申请号：US16981336
申请日：2018-03-18
发明人： Yunying CHEN , Jing LI
IPC分类号： C07K16/28
摘要： The present invention provides novel anti-PD-1 antibodies that specifically bind to cell surface PD-1. Also provided are the nucleic acid molecules encoding the anti-PD-1 antibodies, expression vectors and host cells used for the expression of the anti-PD-1 antibodies. The invention further provides the methods for producing the anti-PD-1 antibodies and the use thereof.
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