公开(公告)号：US20120258553A1

公开(公告)日：2012-10-11

申请号：US13518428

申请日：2010-12-16

申请人： Wendy Uyen Dittmer ,  Toon Hendrik Evers ,  David Walterus Cornelis Dekkers ,  Marco Hendrikus Hefti ,  Joost Lambert Max Vissers ,  Michael Franciscus Wilhelmus Cornelis Martens

发明人： Wendy Uyen Dittmer ,  Toon Hendrik Evers ,  David Walterus Cornelis Dekkers ,  Marco Hendrikus Hefti ,  Joost Lambert Max Vissers ,  Michael Franciscus Wilhelmus Cornelis Martens

IPC分类号： G01N27/72

CPC分类号： G01N33/54333 ,  G01N21/552 ,  G01N27/745 ,  G01N33/54393 ,  G01N2446/00

摘要： An apparatus for measuring a target molecule in a sample is disclosed. The apparatus comprises a moiety comprising a magnetic label (1) greater than 100 nm, a binding surface (12) for specifically binding the moiety, the amount of said moiety binding to said surface being indicative of the amount of the target molecule in said sample, detection means (31 31′) for detecting the amount of said moiety bound to said surface, and a salt (51) for reducing aggregation of the magnetic labels of respective moieties in said sample. The apparatus preferably also comprises a magnetic field generator (41) for attracting the magnetic labels to the binding surface. A method for measuring a target molecule in a sample and a disposable cartridge for use with the apparatus are also disclosed.

摘要翻译： 公开了一种用于测量样品中靶分子的装置。 该装置包括包含大于100nm的磁性标签（1）的部分，用于特异性结合该部分的结合表面（12），所述部分结合所述表面的量指示所述样品中靶分子的量 ，用于检测与所述表面结合的所述部分的量的检测装置（31 31'）和用于减少所述样品中各部分的磁性标记物的聚集的盐（51）。 该装置优选地还包括用于将磁性标签吸引到装订表面的磁场发生器（41）。 还公开了一种用于测量样品中的靶分子的方法和用于该设备的一次性盒。

公开(公告)号：US09720003B2

公开(公告)日：2017-08-01

申请号：US13141439

申请日：2009-12-15

申请人： Wendy Uyen Dittmer ,  Toon Hendrik Evers ,  Peggy De Kievit ,  Ricky Kamps ,  Joost Lambert Max Vissers ,  Michael Franciscus Wilhelmus Cornelis Martens ,  David Walterus Cornelis Dekkers

发明人： Wendy Uyen Dittmer ,  Toon Hendrik Evers ,  Peggy De Kievit ,  Ricky Kamps ,  Joost Lambert Max Vissers ,  Michael Franciscus Wilhelmus Cornelis Martens ,  David Walterus Cornelis Dekkers

IPC分类号： G01N33/68 ,  G01N33/543

CPC分类号： G01N33/6887 ,  G01N33/54373 ,  G01N2800/324

摘要： The present invention relates to a method for measuring Troponin I in a sample comprising the steps of providing a sample, contacting the sample with a monoclonal anti-Troponin I antibody coupled to a magnetic label, contacting the sample with a polyclonal anti-Troponin I antibody coupled to a sensor surface and detecting the magnetic label on the sensor surface. The invention further relates to a device and a cartridge for measuring Troponin I in a sample.

公开(公告)号：US20110256640A1

公开(公告)日：2011-10-20

申请号：US13141439

申请日：2009-12-15

申请人： Wendy Uyen Dittmer ,  Toon Hendrik Evers ,  Peggy De Kievit ,  Ricky Kamps ,  Joost Lambert Max Vissers ,  Michael Franciscus Wilhelmus Cornelis Martens ,  David Walterus Cornelis Dekkers

发明人： Wendy Uyen Dittmer ,  Toon Hendrik Evers ,  Peggy De Kievit ,  Ricky Kamps ,  Joost Lambert Max Vissers ,  Michael Franciscus Wilhelmus Cornelis Martens ,  David Walterus Cornelis Dekkers

IPC分类号： G01N33/566 ,  G01N30/00

CPC分类号： G01N33/6887 ,  G01N33/54373 ,  G01N2800/324

摘要： The present invention relates to a method for measuring Troponin I in a sample comprising the steps of providing a sample, contacting the sample with a monoclonal anti-Troponin I antibody coupled to a magnetic label, contacting the sample with a polyclonal anti-Troponin I antibody coupled to a sensor surface and detecting the magnetic label on the sensor surface. The invention further relates to a device and a cartridge for measuring Troponin I in a sample.

摘要翻译： 本发明涉及一种测量样品中肌钙蛋白I的方法，包括以下步骤：提供样品，使样品与偶联至磁性标签的单克隆抗肌钙蛋白I抗体接触，使样品与多克隆抗肌钙蛋白I抗体 耦合到传感器表面并检测传感器表面上的磁性标签。 本发明还涉及用于测量样品中的肌钙蛋白I的装置和盒。