公开(公告)号：US09623049B2

公开(公告)日：2017-04-18

申请号：US13669194

申请日：2012-11-05

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Zelig Eshhar ,  Assaf Marcus ,  Tova Waks

IPC: A61K35/26 ,  A61K35/28 ,  A61K38/00 ,  A61K35/17 ,  A61K31/137 ,  A61K31/197 ,  A61K31/4245 ,  C12N5/0783 ,  A61K31/135 ,  A61K31/185 ,  A61K31/196 ,  A61K31/661 ,  A61K31/675 ,  A61K31/7076 ,  A61K39/395 ,  A61K47/48 ,  A61K48/00 ,  A61N5/10 ,  B82Y5/00 ,  A61K35/12

CPC classification number: A61K35/17 ,  A61K31/135 ,  A61K31/137 ,  A61K31/185 ,  A61K31/196 ,  A61K31/197 ,  A61K31/4245 ,  A61K31/661 ,  A61K31/675 ,  A61K31/7076 ,  A61K39/39541 ,  A61K47/6891 ,  A61K48/00 ,  A61K2035/124 ,  A61N5/10 ,  B82Y5/00 ,  C07K16/32 ,  C07K2317/24 ,  C07K2317/622 ,  C07K2317/732 ,  C12N5/0636 ,  C12N5/0638 ,  C12N2501/2302 ,  C12N2501/50 ,  C12N2501/51 ,  C12N2501/515 ,  C12N2501/59 ,  C12N2501/599 ,  C12N2510/00

Abstract: A method of treating a disease, such as cancer, by administering to a subject in need of such treatment an effective amount of allogeneic T cells with a MHC unrestricted chimeric receptor short time after partial lymphodepletion. The method also comprises administering one or more agents that delay egression of the allogeneic T cells from lymph nodes of said subject during adoptive transfer of said allogeneic T cells to the subject by trapping the T cells in the lymph nodes.