公开(公告)号：US09696310B2

公开(公告)日：2017-07-04

申请号：US14738894

申请日：2015-06-14

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： David Margulies ,  Leila Motiei ,  Linor Unger

IPC: C07D417/14 ,  G01N33/573 ,  C07D417/06 ,  C09K11/06 ,  G01N33/58 ,  C07F9/6541 ,  C07K7/06 ,  G01N33/574

CPC classification number: G01N33/573 ,  C07D417/06 ,  C07D417/14 ,  C07F9/6541 ,  C07K7/06 ,  C09K11/06 ,  C09K2211/1029 ,  C09K2211/1037 ,  G01N33/574 ,  G01N33/582 ,  G01N2333/91177 ,  G01N2333/918 ,  G01N2333/96494

Abstract: The present invention is directed to fluorescent molecular sensor based on Thiazole Orange for protein detection. Interaction of the protein target with the molecular sensors of this invention results in a significant increase in the fluorescence emission. The generation of light output signal enables one to detect protein biomarkers associated with different diseases or detecting the protein of interest also in living cells.

公开(公告)号：US10557853B2

公开(公告)日：2020-02-11

申请号：US15640545

申请日：2017-07-02

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： David Margulies ,  Leila Motiei ,  Linor Unger

IPC: C07D417/06 ,  G01N33/58 ,  C07D417/14 ,  C07K7/06 ,  C09K11/06 ,  G01N33/573 ,  G01N33/574

Abstract: The present invention is directed to fluorescent molecular sensor based on Thiazole Orange for protein detection. Interaction of the protein target with the molecular sensors of this invention results in a significant increase in the fluorescence emission. The generation of light output signal enables one to detect protein biomarkers associated with different diseases or detecting the protein of interest also in living cells.

公开(公告)号：US20150276753A1

公开(公告)日：2015-10-01

申请号：US14738894

申请日：2015-06-14

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： David MARGULIES ,  Leila Motiei ,  Linor Unger

IPC: G01N33/58 ,  C07F9/6541 ,  C07D417/06 ,  C07D417/14 ,  G01N33/573

CPC classification number: G01N33/573 ,  C07D417/06 ,  C07D417/14 ,  C07F9/6541 ,  C07K7/06 ,  C09K11/06 ,  C09K2211/1029 ,  C09K2211/1037 ,  G01N33/574 ,  G01N33/582 ,  G01N2333/91177 ,  G01N2333/918 ,  G01N2333/96494

Abstract: The present invention is directed to fluorescent molecular sensor based on Thiazole Orange for protein detection. Interaction of the protein target with the molecular sensors of this invention results in a significant increase in the fluorescence emission. The generation of light output signal enables one to detect protein biomarkers associated with different diseases or detecting the protein of interest also in living cells.

Abstract translation: 本发明涉及基于噻唑橙用于蛋白质检测的荧光分子传感器。 蛋白质靶标与本发明的分子传感器的相互作用导致荧光发射的显着增加。 光输出信号的产生使得人们能够检测与不同疾病相关的蛋白质生物标志物或检测活细胞中感兴趣的蛋白质。