公开(公告)号：US20230366885A1

公开(公告)日：2023-11-16

申请号：US18350066

申请日：2023-07-11

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： David MARGULIES ,  Leila Motiei ,  Naama Lahav ,  Pragati Prasad

IPC: G01N33/58 ,  G01N33/574

CPC classification number: G01N33/582 ,  G01N33/574

Abstract: The disclosure presented herein provides DNA constructs, recombinant cells comprising thereof, system comprising thereof, bacterial probes, and/or a recombinant cell decorated with various labels and/or synthetic agents, wherein said labels and/or synthetic agents can be reversibly modified or removed from the cells. Also disclosed herein are methods for decorating and/or modifying cells, preferably bacteria cells, and methods for using thereof.

公开(公告)号：US11639929B2

公开(公告)日：2023-05-02

申请号：US16783524

申请日：2020-02-06

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： David Margulies ,  Leila Motiei ,  Naama Lahav

IPC: C07D249/04 ,  G01N33/533 ,  G01N33/68 ,  G01N33/58

Abstract: This invention is directed to His-tag binding compounds and uses thereof in the preparation of genetically targeted detectable molecules and sensors which can specifically bind tag-labeled proteins. This invention further provides a system comprising recombinant cells decorated with various labels and/or synthetic agents, wherein said labels and/or synthetic agents can be reversibly modified or removed from the cells. Also disclosed herein are methods for decorating and/or modifying the cells and methods for using thereof.