公开(公告)号：US20220362329A1

公开(公告)日：2022-11-17

申请号：US17875551

申请日：2022-07-28

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Eran ELINAV ,  Ido AMIT ,  Aleksandra Anna KOLODZIEJCZYK

IPC: A61K38/14 ,  A61P1/16 ,  A61K31/43 ,  A61K31/7036 ,  A61K31/4164

Abstract: Methods of treating acute liver disease acute liver diseases are provided. Accordingly, there is provided a method of treating acute liver disease in a subject in need thereof comprising administering to the subject a therapeutically effective amount of an agent capable of binding a component of a TLR-MYC signaling pathway selected from the group consisting of MYC, MYD88, TRIF and p38 and inhibiting expression and/or activity of the component.