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公开(公告)号:US20230223147A1
公开(公告)日:2023-07-13
申请号:US18123435
申请日:2023-03-20
发明人: Eran SEGAL , Eran ELINAV
摘要: Method of predicting a response of a subject to food is disclosed. The method comprises: selecting a food to which a response of the subject is unknown; accessing a first database having data describing the subject but not a response of the subject to the selected food; accessing a second database having data pertaining to responses of other subjects to foods, the responses of the other subjects including responses of at least one other subject to the selected food or a food similar to said selected food; and analyzing the databases based on the selected food to estimate the response of the subject to the selected food.
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公开(公告)号:US20210142905A1
公开(公告)日:2021-05-13
申请号:US17151232
申请日:2021-01-18
发明人: Eran SEGAL , Eran ELINAV
摘要: Method of predicting a response of a subject to food is disclosed. The method comprises: selecting a food to which a response of the subject is unknown; accessing a first database having data describing the subject but not a response of the subject to the selected food; accessing a second database having data pertaining to responses of other subjects to foods, the responses of the other subjects including responses of at least one other subject to the selected food or a food similar to said selected food; and analyzing the databases based on the selected food to estimate the response of the subject to the selected food.
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公开(公告)号:US20190022152A1
公开(公告)日:2019-01-24
申请号:US16151455
申请日:2018-10-04
发明人: Eran ELINAV , Eran SEGAL
IPC分类号: A61K35/741 , C12Q1/6883 , C12Q1/04 , C12Q1/02
摘要: A method of determining tolerance to an agent in a healthy subject is disclosed. The method comprises: (a) determining a signature of a microbiome in a sample of the healthy subject who has been subjected to the agent or condition; and (b) comparing the signature of the microbiome of the healthy subject to at least one reference signature of a pathological microbiome, wherein when the signature of the microbiome of the healthy subject is statistically significantly similar to the reference signature of the pathological microbiome, it is indicative that the healthy subject is intolerant to the agent.
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公开(公告)号:US20180140648A1
公开(公告)日:2018-05-24
申请号:US15575827
申请日:2016-05-17
发明人: Eran SEGAL , Eran ELINAV
IPC分类号: A61K35/747 , A61K35/745 , A61P3/08
CPC分类号: A61K35/747 , A61K35/741 , A61K35/744 , A61K35/745 , A61K2300/00 , A61P3/08 , Y02A50/47 , Y02A50/473 , Y02A50/475
摘要: A method of improving the glucose response in glucose tolerant and intolerant subjects is provided. The method comprises providing to the subject probiotic compositions, or agents which specifically reduce bacterial species.
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公开(公告)号:US20220184154A1
公开(公告)日:2022-06-16
申请号:US17681946
申请日:2022-02-28
申请人: Yeda Research and Development Co. Ltd. , Hadasit Medical Research Services and Development Ltd.
IPC分类号: A61K35/747 , A61P31/04
摘要: A method of treating bacterial vaginosis in a subject is disclosed. The method comprises administering to the subject a therapeutically effective amount of a composition which comprises between three and twenty species of bacteria or a secretion thereof, wherein at least 70% of the bacteria of the composition are of the species Lactobacillus crispatus, thereby treating the bacterial vaginosis.
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公开(公告)号:US20210269860A1
公开(公告)日:2021-09-02
申请号:US17258477
申请日:2019-07-08
申请人: Yeda Research and Development Co. Ltd. , The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center
发明人: Eran SEGAL , Eran ELINAV , Zamir HALPERN
摘要: A method of assessing whether a candidate subject is suitable for probiotic treatment is disclosed. The method comprises determining a signature of the gut microbiome of the candidate subject, wherein when the signature of the microbiome of the candidate subject is statistically significantly similar to a signature of a gut microbiome of a control subject known to be responsive to probiotic treatment, it is indicative that the subject is suitable for probiotic treatment.
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7.
公开(公告)号:US20200368322A1
公开(公告)日:2020-11-26
申请号:US16986473
申请日:2020-08-06
发明人: Benjamin GEIGER , Eran ELINAV , Inna GROSHEVA
摘要: A method of treating a disease associated with intestinal barrier dysfunction in a subject is disclosed. The method comprises administering to the subject a therapeutically effective amount of an agent which downregulates the amount of glucose in intestinal cells, with the proviso that the disease is not Diabetes or obesity. Other agents for treating diseases associated with intestinal barrier dysfunction are also disclosed.
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公开(公告)号:US20190382827A1
公开(公告)日:2019-12-19
申请号:US16525669
申请日:2019-07-30
发明人: Eran ELINAV , Eran SEGAL
IPC分类号: C12Q1/689 , A61P1/00 , A61K31/132 , A61K31/417
摘要: A method of determining the therapeutic effect of an agent, such as a metabolite, comprising: (a) exposing a pathological microbiome to the agent; and (b) comparing the signature of the pathological microbiome following the exposing with a reference signature of a healthy microbiome, wherein when the signature of the microbiome is statistically significantly similar to the healthy microbiome reference signature, it is indicative that the agent has a therapeutic effect on the microbiome. The agent may be provided to a subject having a pathological microbiome once it has been classified as therapeutic.
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公开(公告)号:US20190102512A1
公开(公告)日:2019-04-04
申请号:US15525093
申请日:2015-11-17
发明人: Eran SEGAL , Eran ELINAV
IPC分类号: C12Q1/6888 , G06F17/18
摘要: A method of assessing the growth dynamics of a bacterium in a microbiome is disclosed.
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10.
公开(公告)号:US20240094224A1
公开(公告)日:2024-03-21
申请号:US18522466
申请日:2023-11-29
发明人: Eran ELINAV , Alon SAVIDOR
IPC分类号: G01N33/68
CPC分类号: G01N33/6893 , G01N2333/4721 , G01N2800/065 , G01N2800/26 , G01N2800/60
摘要: Proxies for physiological states of tissue are provided. Accordingly, there are provided methods of determining host AMP landscape, establishing a profile indicative of tissue status, and identifying proxies for tissue status in AMP profiles of samples of secretions, exudates and/or excretions of the tissue. Also provided are methods for determination of disease severity and chronology.
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