公开(公告)号：US20240239886A1

公开(公告)日：2024-07-18

申请号：US18432214

申请日：2024-02-05

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Ido AMIT ,  Chamutal BORNSTEIN-OVITS ,  Adam YALIN ,  Adi MOSHE ,  Oren BARBOY ,  Assaf WEINER ,  Yonatan KATZENELENBOGEN ,  Diego JAITIN ,  Fadi SHEBAN

IPC: C07K16/28 ,  A61K35/17 ,  A61K39/00 ,  A61K45/06 ,  A61K47/64 ,  A61P35/00 ,  A61P37/04

CPC classification number: C07K16/2803 ,  A61K35/17 ,  A61K39/4611 ,  A61K39/4631 ,  A61K39/464411 ,  A61K45/06 ,  A61K47/642 ,  A61P35/00 ,  A61P37/04 ,  A61K2039/505 ,  C07K2317/565 ,  C07K2317/71

Abstract: Provided are antibodies to TREM2 and Gpnmb. Also provided are compositions comprising the antibodies and methods of using same.

公开(公告)号：US20220307008A1

公开(公告)日：2022-09-29

申请号：US17619722

申请日：2020-06-16

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Ido AMIT ,  Ido YOFE ,  Diego JAITIN ,  Yonatan KATZENELENBOGEN ,  Mami LENNIKOV ,  Assaf WEINER ,  Hadas KEREN-SHAUL

IPC: C12N15/10 ,  C12Q1/6806 ,  C12N15/11

Abstract: A method of permeabilizing a cell is disclosed. Kits for permeabilizing cells and analysing RNA contents are also disclosed.

公开(公告)号：US20220392571A1

公开(公告)日：2022-12-08

申请号：US17884594

申请日：2022-08-10

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Ido AMIT ,  Amos TANAY ,  Amir GILADI ,  Merav COHEN

IPC: G16B25/10

Abstract: A method of determining cell members of a cell cluster in a tissue of interest is disclosed. The cell members physically interact with one another in the cell cluster. Computer software products capable of carrying out the method are also disclosed.

公开(公告)号：US20190203270A1

公开(公告)日：2019-07-04

申请号：US16319499

申请日：2016-07-24

Applicant: Yeda Research and Development Co., Ltd.

Inventor： Ido AMIT ,  David LARA-ASTIASO ,  Meital GURY

IPC: C12Q1/6811 ,  C12Q1/6818 ,  C12Q1/6876

CPC classification number: C12Q1/6811 ,  C12Q1/6816 ,  C12Q1/6818 ,  C12Q1/6876 ,  C12Q2600/154 ,  C12Q2600/156 ,  G01N33/6875 ,  C12Q2522/101 ,  C12Q2563/185

Abstract: Methods of analyzing DNA molecules in a cell sample are provided. The DNA molecules have DNA binding moiety signatures which are defined by at least two non-identical DNA binding moieties. Kits for analyzing the DNA are also provided.

公开(公告)号：US20220372145A1

公开(公告)日：2022-11-24

申请号：US17876641

申请日：2022-07-29

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Ido AMIT ,  Assaf WEINER ,  Yonatan KATZENELENBOGEN ,  Adam YALIN ,  Fadi SHEBAN

IPC: C07K16/28 ,  C07K16/30

Abstract: A method of reducing the immune suppressor activity of myeloid cells is disclosed. The method comprises contacting myeloid cells with an effective amount of an agent which specifically reduces the amount and/or activity of myeloid cells expressing both Triggering Receptor Expressed On Myeloid Cells 2 (Trem2) and Transmembrane glycoprotein NMB (Gpnmb). The method can be used for treating cancer. Antibodies and bi-specific antibodies are also disclosed.

公开(公告)号：US20220362329A1

公开(公告)日：2022-11-17

申请号：US17875551

申请日：2022-07-28

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Eran ELINAV ,  Ido AMIT ,  Aleksandra Anna KOLODZIEJCZYK

IPC: A61K38/14 ,  A61P1/16 ,  A61K31/43 ,  A61K31/7036 ,  A61K31/4164

Abstract: Methods of treating acute liver disease acute liver diseases are provided. Accordingly, there is provided a method of treating acute liver disease in a subject in need thereof comprising administering to the subject a therapeutically effective amount of an agent capable of binding a component of a TLR-MYC signaling pathway selected from the group consisting of MYC, MYD88, TRIF and p38 and inhibiting expression and/or activity of the component.

公开(公告)号：US20210293820A1

公开(公告)日：2021-09-23

申请号：US17334862

申请日：2021-05-31

Applicant: Yeda Research and Development Co. Ltd. ,  Stichting Het Nederlands Kanker Instituut - Antoni Van Leeuwenhoek Ziekenhuis

Inventor： Ido AMIT ,  Hanjie LI ,  Amos TANAY ,  Ido YOFE ,  Yaniv EYAL-LUBLING ,  Antonius Nicolaas Maria SCHUMACHER ,  Anne Magdalena VAN DER LEUN

IPC: G01N33/574 ,  C12N15/113 ,  G01N33/50

Abstract: Method of activating dysfunctional T cells, determining responsiveness of a subject having a tumor to an immune checkpoint inhibition are provided. Also provided is an agent capable of inhibiting a target gene or expression product thereof for use in treating a subject having a tumor. Additionally or alternatively provided is an immune checkpoint inhibitor and an agent capable of inhibiting a target gene or expression product thereof for use in treating a subject having a tumor.

公开(公告)号：US20210177895A1

公开(公告)日：2021-06-17

申请号：US17183593

申请日：2021-02-24

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Ido AMIT ,  Merav COHEN ,  Amir GILADI

IPC: A61K35/15 ,  C12N5/0787

Abstract: A method of treating a disease or disorder that can benefit from increasing an M2/M1 macrophage ratio in a subject in need thereof is provided. The method comprising: (a) culturing basophils in the presence of IL33 and/or GM-SCF; and (b) administering to the subject a therapeutically effective amount of the basophils following the culturing, thereby treating the disease or disorder that can benefit from increasing an M2/M1 macrophage ratio in the subject.

公开(公告)号：US20200263168A1

公开(公告)日：2020-08-20

申请号：US16784276

申请日：2020-02-07

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Diego JAITIN ,  Ido AMIT ,  Hadas KEREN-SHAUL ,  Liran VALADARSKY

IPC: C12N15/10 ,  C12Q1/6809 ,  C12Q1/6806

Abstract: Kits and methods for single cell or multiple cell transcriptome analysis are provided. An adapter polynucleotide is disclosed which comprises a double-stranded DNA portion of 15 base pairs and no more than 100 base pairs with a 3′single stranded overhang of at least 3 bases and no more than 10 bases, wherein the double stranded DNA portion is at the 5′ end of the polynucleotide and wherein the sequence of the 3′single stranded overhang is selected from the group consisting of SEQ ID NOs: 1-8 and 9, wherein the 5′ end of the strand of the double-stranded DNA which is devoid of the 3′single stranded overhang comprises a free phosphate.

公开(公告)号：US20180028650A1

公开(公告)日：2018-02-01

申请号：US15549161

申请日：2016-02-09

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Irit SAGI ,  Dalit TALMI - FRANK ,  Inna SOLOMONOV ,  Ido AMIT

IPC: A61K39/395 ,  A61K31/196 ,  A61K31/215 ,  C07K16/40 ,  A61K31/351

CPC classification number: A61K39/3955 ,  A61K31/196 ,  A61K31/215 ,  A61K31/351 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/40 ,  A61K2300/00

Abstract: A method of treating or preventing a disease associated with a secondary infection in a subject infected with a pathogen is provided. The method comprises administering to the subject a therapeutically effective amount of an anti-pathogenic agent directed towards the pathogen and a therapeutically effective amount of an agent which down-regulates at least one extracellular matrix-associated polypeptide.