公开(公告)号：US20180071369A1

公开(公告)日：2018-03-15

申请号：US15561053

申请日：2016-03-31

Applicant: Yeda Research and Development Co. Ltd.

Inventor： David MIRELMAN ,  Aharon RABINKOV ,  Angela RUBAN ,  Ghil JONA ,  Eli HAZUM ,  Vladas BUMELIS ,  Nerijus MAKAUSKAS ,  Saule SUDZIUVIENE ,  Elena NARMONTAITE

IPC: A61K38/45 ,  C12N9/10

CPC classification number: A61K38/45 ,  C12N9/1096 ,  C12Y206/01001

Abstract: A protein preparation comprising Glutamate Oxaloacetate Transaminase 1 (GOT1) polypeptide molecules is disclosed, the GOT1 being identical in its sequence to that present in human serum. 100% of the GOT1 polypeptide molecules of the preparation have an alanine at position 1 of the GOT1 polypeptide. The GOT1 polypeptide molecules constitute at least 95% of the proteins in the preparation. Methods of generating same and uses thereof are also disclosed.