公开(公告)号：US20180071369A1

公开(公告)日：2018-03-15

申请号：US15561053

申请日：2016-03-31

Applicant: Yeda Research and Development Co. Ltd.

Inventor： David MIRELMAN ,  Aharon RABINKOV ,  Angela RUBAN ,  Ghil JONA ,  Eli HAZUM ,  Vladas BUMELIS ,  Nerijus MAKAUSKAS ,  Saule SUDZIUVIENE ,  Elena NARMONTAITE

IPC: A61K38/45 ,  C12N9/10

CPC classification number: A61K38/45 ,  C12N9/1096 ,  C12Y206/01001

Abstract: A protein preparation comprising Glutamate Oxaloacetate Transaminase 1 (GOT1) polypeptide molecules is disclosed, the GOT1 being identical in its sequence to that present in human serum. 100% of the GOT1 polypeptide molecules of the preparation have an alanine at position 1 of the GOT1 polypeptide. The GOT1 polypeptide molecules constitute at least 95% of the proteins in the preparation. Methods of generating same and uses thereof are also disclosed.

公开(公告)号：US20190091300A1

公开(公告)日：2019-03-28

申请号：US16197435

申请日：2018-11-21

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Vivian I. TEICHBERG ,  Angela RUBAN

IPC: A61K38/45 ,  A61K31/194 ,  A61K31/495 ,  A61K38/44 ,  A61K38/51 ,  A61K38/53 ,  A61K31/198 ,  A61K31/19 ,  A61K38/52

Abstract: A method of treating a cancer of the central nervous system in a subject in need thereof is provided. The method comprising administering to the subject a therapeutically effective amount of an agent which reduces blood glutamate levels and enhances brain to blood glutamate efflux to thereby treat the cancer of the central nervous system in the subject.