公开(公告)号：US20240239886A1

公开(公告)日：2024-07-18

申请号：US18432214

申请日：2024-02-05

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Ido AMIT ,  Chamutal BORNSTEIN-OVITS ,  Adam YALIN ,  Adi MOSHE ,  Oren BARBOY ,  Assaf WEINER ,  Yonatan KATZENELENBOGEN ,  Diego JAITIN ,  Fadi SHEBAN

IPC: C07K16/28 ,  A61K35/17 ,  A61K39/00 ,  A61K45/06 ,  A61K47/64 ,  A61P35/00 ,  A61P37/04

CPC classification number: C07K16/2803 ,  A61K35/17 ,  A61K39/4611 ,  A61K39/4631 ,  A61K39/464411 ,  A61K45/06 ,  A61K47/642 ,  A61P35/00 ,  A61P37/04 ,  A61K2039/505 ,  C07K2317/565 ,  C07K2317/71

Abstract: Provided are antibodies to TREM2 and Gpnmb. Also provided are compositions comprising the antibodies and methods of using same.

公开(公告)号：US20220372145A1

公开(公告)日：2022-11-24

申请号：US17876641

申请日：2022-07-29

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Ido AMIT ,  Assaf WEINER ,  Yonatan KATZENELENBOGEN ,  Adam YALIN ,  Fadi SHEBAN

IPC: C07K16/28 ,  C07K16/30

Abstract: A method of reducing the immune suppressor activity of myeloid cells is disclosed. The method comprises contacting myeloid cells with an effective amount of an agent which specifically reduces the amount and/or activity of myeloid cells expressing both Triggering Receptor Expressed On Myeloid Cells 2 (Trem2) and Transmembrane glycoprotein NMB (Gpnmb). The method can be used for treating cancer. Antibodies and bi-specific antibodies are also disclosed.