公开(公告)号：US20250032566A1

公开(公告)日：2025-01-30

申请号：US18713665

申请日：2022-12-05

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Rotem SOREK ,  Erez YIRMIYA ,  Azita LEAVITT ,  Gil AMITAI ,  Jeremy Elliot GARB

IPC: A61K35/76 ,  C12N7/00

Abstract: Genetically modified phages are provided. Accordingly, there is provided a genetically modified phage comprising a polynucleotide encoding an anti-defense system polypeptide. Also provided are methods of producing and using same.

公开(公告)号：US20250049835A1

公开(公告)日：2025-02-13

申请号：US18926385

申请日：2024-10-25

Applicant: Yeda Research and Development Co. Ltd. ,  Dana-Farber Cancer Institute, Inc.

Inventor： Rotem SOREK ,  Gil AMITAI ,  Azita LEAVITT ,  Erez YIRMIYA ,  Philip J. KRANZUSCH ,  Allen LU ,  Samuel J. HOBBS

IPC: A61K31/7076 ,  A61K39/39 ,  A61K39/395

Abstract: Methods of treating a disease or disorder associated with a down or up-regulation of an immune response of a subject are disclosed. The methods comprising administering to the subject a therapeutically effective amount of any one or more of the molecule 1′-2′ glycosyl cyclic adenosine diphosphate ribose (1′-2′ gcADPR), 1′-3′ gcADPR or Tad1 protein.

公开(公告)号：US20190264213A1

公开(公告)日：2019-08-29

申请号：US16346124

申请日：2017-11-28

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Rotem SOREK ,  Gil AMITAI ,  Erez ZOHAR

IPC: C12N15/63 ,  C12N15/75

Abstract: Methods of expressing an expression product of interest are provided. Accordingly there is provided a method comprising introducing into a cell a polynucleotide comprising an AimR responsive element operatively linked to a nucleic acid sequence encoding the expression product of interest, and contacting said cell with an AimP peptide comprising an amino acid sequence of XXXXGG/A, wherein said AimP peptide is capable of binding said AimR polypeptide and dissociating said AimR polypeptide from said AimR responsive element. Also provided are articles of manufacture, isolated peptides, polynucleotides and nucleic acid constructs.