公开(公告)号：US20250032566A1

公开(公告)日：2025-01-30

申请号：US18713665

申请日：2022-12-05

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Rotem SOREK ,  Erez YIRMIYA ,  Azita LEAVITT ,  Gil AMITAI ,  Jeremy Elliot GARB

IPC: A61K35/76 ,  C12N7/00

Abstract: Genetically modified phages are provided. Accordingly, there is provided a genetically modified phage comprising a polynucleotide encoding an anti-defense system polypeptide. Also provided are methods of producing and using same.

公开(公告)号：US20250049835A1

公开(公告)日：2025-02-13

申请号：US18926385

申请日：2024-10-25

Applicant: Yeda Research and Development Co. Ltd. ,  Dana-Farber Cancer Institute, Inc.

Inventor： Rotem SOREK ,  Gil AMITAI ,  Azita LEAVITT ,  Erez YIRMIYA ,  Philip J. KRANZUSCH ,  Allen LU ,  Samuel J. HOBBS

IPC: A61K31/7076 ,  A61K39/39 ,  A61K39/395

Abstract: Methods of treating a disease or disorder associated with a down or up-regulation of an immune response of a subject are disclosed. The methods comprising administering to the subject a therapeutically effective amount of any one or more of the molecule 1′-2′ glycosyl cyclic adenosine diphosphate ribose (1′-2′ gcADPR), 1′-3′ gcADPR or Tad1 protein.

公开(公告)号：US20160287677A1

公开(公告)日：2016-10-06

申请号：US15131102

申请日：2016-04-18

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Rotem SOREK ,  Hila SBERRO ,  Azita LEAVITT

IPC: A61K38/45

CPC classification number: A61K38/45 ,  A61K38/00 ,  C07K14/8107 ,  C12N9/1241 ,  C12N9/22 ,  C12Y207/07

Abstract: An isolated polypeptide is disclosed comprising an amino acid sequence selected from the group consisting of SEQ ID NOs: 2773-5544 and 11089-11094, wherein the polypeptide has antimicrobial activity. Uses thereof for treating microbial infections are also disclosed.

Abstract translation: 公开了分离的多肽，其包含选自SEQ ID NO：2773-5544和11089-11094的氨基酸序列，其中所述多肽具有抗微生物活性。 还公开了其用于治疗微生物感染的用途。