公开(公告)号：US20250032566A1

公开(公告)日：2025-01-30

申请号：US18713665

申请日：2022-12-05

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Rotem SOREK ,  Erez YIRMIYA ,  Azita LEAVITT ,  Gil AMITAI ,  Jeremy Elliot GARB

IPC: A61K35/76 ,  C12N7/00

Abstract: Genetically modified phages are provided. Accordingly, there is provided a genetically modified phage comprising a polynucleotide encoding an anti-defense system polypeptide. Also provided are methods of producing and using same.

公开(公告)号：US20250049835A1

公开(公告)日：2025-02-13

申请号：US18926385

申请日：2024-10-25

Applicant: Yeda Research and Development Co. Ltd. ,  Dana-Farber Cancer Institute, Inc.

Inventor： Rotem SOREK ,  Gil AMITAI ,  Azita LEAVITT ,  Erez YIRMIYA ,  Philip J. KRANZUSCH ,  Allen LU ,  Samuel J. HOBBS

IPC: A61K31/7076 ,  A61K39/39 ,  A61K39/395

Abstract: Methods of treating a disease or disorder associated with a down or up-regulation of an immune response of a subject are disclosed. The methods comprising administering to the subject a therapeutically effective amount of any one or more of the molecule 1′-2′ glycosyl cyclic adenosine diphosphate ribose (1′-2′ gcADPR), 1′-3′ gcADPR or Tad1 protein.