公开(公告)号：US09938316B2

公开(公告)日：2018-04-10

申请号：US14913366

申请日：2014-08-27

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Steven J. D. Karlish ,  Adriana Katz ,  Daniel M. Tal ,  Arie Marcovich

IPC: C07J43/00 ,  C07J19/00

CPC classification number: C07J43/003 ,  C07J19/005

Abstract: The present invention relates to digoxin and digitoxin derivatives that are selective inhibitors of the α2 isoform of Na,K-ATPase, and that reduce intra-ocular pressure. The invention further relates to uses of these derivatives for treating disorders associated with elevated intraocular pressure, such as glaucomas, and/or as cardiotonic agents.

公开(公告)号：US10668094B2

公开(公告)日：2020-06-02

申请号：US15745441

申请日：2016-07-19

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Steven J. D. Karlish ,  Adriana Katz ,  Daniel M. Tal ,  Arie Marcovich

IPC: C07H17/00 ,  C07J43/00 ,  C07J19/00 ,  A61K31/7052 ,  A61P27/06 ,  A61P9/00

Abstract: Provided herein are alpha2-selective Na,K-ATPase inhibitors and prodrugs thereof, characterized by having a cyclic moiety attached to a digoxin or digitoxin derivative, as well as uses thereof in lowering intraocular pressure and in treating glaucoma and heart conditions.

公开(公告)号：US11077128B2

公开(公告)日：2021-08-03

申请号：US16847737

申请日：2020-04-14

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Steven J. D. Karlish ,  Adriana Katz ,  Daniel M. Tal ,  Arie Marcovich

IPC: A61K31/7052 ,  C07H17/00 ,  C07J43/00 ,  A61P27/06 ,  A61P9/00 ,  C07J19/00

Abstract: Provided herein are alpha2-selective Na,K-ATPase inhibitors and prodrugs thereof, characterized by having a cyclic moiety attached to a digoxin or digitoxin derivative, as well as uses thereof in lowering intraocular pressure and in treating glaucoma and heart conditions.