公开(公告)号：US20060253162A1

公开(公告)日：2006-11-09

申请号：US11125068

申请日：2005-05-09

申请人： Yi Zhang ,  Yinghong Yu ,  Aaron McCabe ,  Jiang Ding ,  Jeffrey Stahmann ,  Carlos Ricci ,  Scott Meyer

发明人： Yi Zhang ,  Yinghong Yu ,  Aaron McCabe ,  Jiang Ding ,  Jeffrey Stahmann ,  Carlos Ricci ,  Scott Meyer

IPC分类号： A61N1/365

CPC分类号： A61N1/3712 ,  A61N1/3627 ,  A61N1/365 ,  G06F19/00

摘要： Cardiac monitoring and/or stimulation methods and systems that provide one or more of monitoring, diagnosing, defibrillation, and pacing. Cardiac signal separation is employed to detect, monitor, track and/or trend closed-loop cardiac resynchronization therapy using cardiac activation sequence information. Devices and methods involve sensing a plurality of composite cardiac signals using a plurality of electrodes, the electrodes configured for implantation in a patient. A source separation is performed using the sensed plurality of composite cardiac signals, producing one or more cardiac signal vectors associated with all or a portion of one or more cardiac activation sequences. A cardiac resynchronization therapy is adjusted using one or both of the one or more cardiac signal vectors and the signals associated with the one or more cardiac signal vectors. In further embodiments, the cardiac resynchronization therapy may be initiated, terminated, or one or more parameters of the resynchronization therapy may be altered.

摘要翻译： 提供一种或多种监测，诊断，除颤和起搏的心脏监测和/或刺激方法和系统。 心脏信号分离用于使用心脏激活序列信息来检测，监测，跟踪和/或趋势闭环心脏再同步治疗。 设备和方法包括使用多个电极感测多个复合心脏信号，所述电极被配置用于植入患者体内。 使用所感测的多个复合心脏信号进行源分离，产生与一个或多个心脏激活序列的全部或一部分相关联的一个或多个心脏信号载体。 使用一个或多个心脏信号向量和与一个或多个心脏信号载体相关联的信号中的一个或两个来调整心脏再同步治疗。 在另外的实施方案中，心脏再同步治疗可以被启动，终止，或者可以改变再同步治疗的一个或多个参数。

公开(公告)号：US20060069322A1

公开(公告)日：2006-03-30

申请号：US10955397

申请日：2004-09-30

申请人： Yi Zhang ,  Scott Meyer ,  Aaron McCabe ,  Jeffrey Stahmann ,  Yinghong Yu ,  Carlos Ricci

发明人： Yi Zhang ,  Scott Meyer ,  Aaron McCabe ,  Jeffrey Stahmann ,  Yinghong Yu ,  Carlos Ricci

IPC分类号： A61B5/0402

CPC分类号： A61B5/04011 ,  A61B5/7203

摘要： Cardiac monitoring and/or stimulation methods and systems provide monitoring, diagnosis, and defibrillation and/or pacing therapies. A signal processor receives a plurality of composite signals associated with a plurality of sources, performs a source separation, and produces one or more cardiac signal vectors associated with all or a portion of one or more cardiac activation sequences based on the source separation. A method of signal separation involves detecting a change in a characteristic of the cardiac signal vector relative to a baseline. One or more vectors and/or activation sequences may be selected, and information associated with the vectors and/or activation sequences may be stored and tracked.

公开(公告)号：US20060253044A1

公开(公告)日：2006-11-09

申请号：US11125020

申请日：2005-05-09

申请人： Yi Zhang ,  Carlos Ricci ,  Jeffrey Stahmann ,  Aaron McCabe ,  Scott Meyer ,  Yinghong Yu

发明人： Yi Zhang ,  Carlos Ricci ,  Jeffrey Stahmann ,  Aaron McCabe ,  Scott Meyer ,  Yinghong Yu

IPC分类号： A61B5/04

CPC分类号： A61B5/04011 ,  A61B5/7203

摘要： Cardiac monitoring and/or stimulation methods and systems provide for monitoring, diagnosing, defibrillation and pacing therapies, or a combination of these capabilities, including cardiac systems incorporating or cooperating with neuro-stimulating devices, drug pumps, or other therapies. Embodiments of the present invention relate generally to implantable medical devices employing automated cardiac activation sequence monitoring and/or tracking for arrhythmia discrimination. Embodiments of the invention are directed to devices and methods involving sensing a plurality of composite cardiac signals using a plurality of implantable electrodes. A source separation is performed using the sensed plurality of composite cardiac signals and the separation produces one or more cardiac signal vectors associated with one or more cardiac activation sequences that is indicative of ischemia. A change of the one or more cardiac signal vectors is detected using the one or more cardiac signal vectors. Cardiac arrhythmias are discriminated using the one or more cardiac signal vectors.

摘要翻译： 心脏监测和/或刺激方法和系统提供监测，诊断，除颤和起搏治疗，或这些功能的组合，包括结合或与神经刺激装置，药物泵或其他疗法组合的心脏系统。 本发明的实施方案一般涉及使用自动心脏激活序列监测和/或跟踪用于心律失常鉴别的可植入医疗装置。 本发明的实施例涉及使用多个可植入电极感测多个复合心脏信号的装置和方法。 使用感测的多个复合心脏信号进行源分离，并且分离产生与指示缺血的一个或多个心脏激活序列相关联的一个或多个心脏信号载体。 使用一个或多个心脏信号矢量检测一个或多个心脏信号矢量的改变。 使用一个或多个心脏信号载体来区分心律失常。

公开(公告)号：US20060116593A1

公开(公告)日：2006-06-01

申请号：US11079744

申请日：2005-03-14

申请人： Yi Zhang ,  Scott Meyer ,  Jeffrey Stahmann ,  Carlos Ricci ,  Marina Brockway ,  Aaron McCabe ,  Yinghong Yu ,  Donald Hopper

发明人： Yi Zhang ,  Scott Meyer ,  Jeffrey Stahmann ,  Carlos Ricci ,  Marina Brockway ,  Aaron McCabe ,  Yinghong Yu ,  Donald Hopper

IPC分类号： A61B5/04

CPC分类号： A61N1/3702 ,  A61B5/0452 ,  A61B5/7203

摘要： Cardiac monitoring and/or stimulation methods and systems that provide one or more of monitoring, diagnosing, defibrillation, and pacing. Cardiac signal separation is employed to detect, monitor, track and/or trend ischemia using cardiac activation sequence information. Ischemia detection may involve sensing composite cardiac signals using implantable electrodes, and performing a signal separation that produces one or more cardiac activation signal vectors associated with one or more cardiac activation sequences. A change in the signal vector may be detected using subsequent separations. The change may be an elevation or depression of the ST segment of a cardiac cycle or other change indicative of myocardial ischemia, myocardial infarction, or other pathological change. The change may be used to predict, quantify, and/or qualify an event such as an arrhythmia, a myocardial infarction, or other pathologic change. Information associated with the vectors may be stored and used to track the vectors.

摘要翻译： 提供一种或多种监测，诊断，除颤和起搏的心脏监测和/或刺激方法和系统。 使用心脏信号分离来使用心脏激活序列信息来检测，监测，跟踪和/或趋势性缺血。 缺血检测可以涉及使用可植入电极感测复合心脏信号，并且执行产生与一个或多个心脏激活序列相关联的一个或多个心脏激活信号载体的信号分离。 可以使用后续分离来检测信号矢量的变化。 该变化可以是心​​脏周期的ST段的升高或抑制或指示心肌缺血，心肌梗死或其他病理变化的其它变化。 该变化可用于预测，量化和/或限定诸如心律失常，心肌梗死或其它病理变化的事件。 与矢量相关联的信息可以被存储并用于跟踪矢量。

公开(公告)号：US07917215B2

公开(公告)日：2011-03-29

申请号：US12276070

申请日：2008-11-21

申请人： Yi Zhang ,  Yinghong Yu ,  Aaron McCabe ,  Jiang Ding ,  Jeffrey E. Stahmann ,  Carlos A. Ricci ,  Scott A. Meyer

发明人： Yi Zhang ,  Yinghong Yu ,  Aaron McCabe ,  Jiang Ding ,  Jeffrey E. Stahmann ,  Carlos A. Ricci ,  Scott A. Meyer

IPC分类号： A61N1/00

CPC分类号： A61N1/3712 ,  A61N1/3627 ,  A61N1/365 ,  G06F19/00

摘要： Cardiac monitoring and/or stimulation methods and systems that provide one or more of monitoring, diagnosing, defibrillation, and pacing. Cardiac signal separation is employed to detect, monitor, track and/or trend closed-loop cardiac resynchronization therapy using cardiac activation sequence information. Devices and methods involve sensing a plurality of composite cardiac signals using a plurality of electrodes, the electrodes configured for implantation in a patient. A source separation is performed using the sensed plurality of composite cardiac signals, producing one or more cardiac signal vectors associated with all or a portion of one or more cardiac activation sequences. A cardiac resynchronization therapy is adjusted using one or both of the one or more cardiac signal vectors and the signals associated with the one or more cardiac signal vectors. In further embodiments, the cardiac resynchronization therapy may be initiated, terminated, or one or more parameters of the resynchronization therapy may be altered.

摘要翻译： 提供一种或多种监测，诊断，除颤和起搏的心脏监测和/或刺激方法和系统。 心脏信号分离用于使用心脏激活序列信息来检测，监测，跟踪和/或趋势闭环心脏再同步治疗。 设备和方法包括使用多个电极感测多个复合心脏信号，所述电极被配置用于植入患者体内。 使用所感测的多个复合心脏信号进行源分离，产生与一个或多个心脏激活序列的全部或一部分相关联的一个或多个心脏信号载体。 使用一个或多个心脏信号向量和与一个或多个心脏信号载体相关联的信号中的一个或两个来调整心脏再同步治疗。 在另外的实施方案中，心脏再同步治疗可以被启动，终止，或者可以改变再同步治疗的一个或多个参数。

公开(公告)号：US08380293B2

公开(公告)日：2013-02-19

申请号：US13027612

申请日：2011-02-15

申请人： Yi Zhang ,  Scott Meyer ,  Aaron McCabe ,  Jeffrey E. Stahmann ,  Yinghong Yu ,  Carlos A Ricci

发明人： Yi Zhang ,  Scott Meyer ,  Aaron McCabe ,  Jeffrey E. Stahmann ,  Yinghong Yu ,  Carlos A Ricci

IPC分类号： A61B5/0428 ,  A61B5/0452

CPC分类号： A61B5/04011 ,  A61B5/7203

摘要： Cardiac monitoring and/or stimulation methods and systems provide monitoring, diagnosis, and defibrillation and/or pacing therapies. A signal processor receives a plurality of composite signals associated with a plurality of sources, performs a source separation, and produces one or more cardiac signal vectors associated with all or a portion of one or more cardiac activation sequences based on the source separation. A method of signal separation involves detecting a change in a characteristic of the cardiac signal vector relative to a baseline. One or more vectors and/or activation sequences may be selected, and information associated with the vectors and/or activation sequences may be stored and tracked.

摘要翻译： 心脏监测和/或刺激方法和系统提供监测，诊断和除颤和/或起搏疗法。 信号处理器接收与多个源相关联的多个复合信号，执行源分离，并且基于源分离产生与一个或多个心脏激活序列的全部或一部分相关联的一个或多个心脏信号矢量。 信号分离的方法包括检测心脏信号矢量相对于基线的特征的变化。 可以选择一个或多个载体和/或激活序列，并且可以存储和跟踪与载体和/或激活序列相关联的信息。

公开(公告)号：US08321002B2

公开(公告)日：2012-11-27

申请号：US13027608

申请日：2011-02-15

申请人： Yi Zhang ,  Carlos A. Ricci ,  Jeffrey E. Stahmann ,  Aaron McCabe ,  Scott Meyer ,  Yinghong Yu

发明人： Yi Zhang ,  Carlos A. Ricci ,  Jeffrey E. Stahmann ,  Aaron McCabe ,  Scott Meyer ,  Yinghong Yu

IPC分类号： A61B5/0464

CPC分类号： A61B5/04011 ,  A61B5/7203

摘要： Cardiac monitoring and/or stimulation methods and systems provide for monitoring, diagnosing, defibrillation and pacing therapies, or a combination of these capabilities, including cardiac systems incorporating or cooperating with neuro-stimulating devices, drug pumps, or other therapies. Embodiments of the present invention relate generally to implantable medical devices employing automated cardiac activation sequence monitoring and/or tracking for arrhythmia discrimination. Embodiments of the invention are directed to devices and methods involving sensing a plurality of composite cardiac signals using a plurality of implantable electrodes. A source separation is performed using the sensed plurality of composite cardiac signals and the separation produces one or more cardiac signal vectors associated with one or more cardiac activation sequences that is indicative of ischemia. A change of the one or more cardiac signal vectors is detected using the one or more cardiac signal vectors. Cardiac arrhythmias are discriminated using the one or more cardiac signal vectors.

摘要翻译： 心脏监测和/或刺激方法和系统提供监测，诊断，除颤和起搏治疗，或这些能力的组合，包括结合或与神经刺激装置，药物泵或其他疗法组合的心脏系统。 本发明的实施方案一般涉及使用自动心脏激活序列监测和/或跟踪用于心律失常鉴别的可植入医疗装置。 本发明的实施例涉及使用多个可植入电极感测多个复合心脏信号的装置和方法。 使用感测的多个复合心脏信号进行源分离，并且分离产生与指示缺血的一个或多个心脏激活序列相关联的一个或多个心脏信号载体。 使用一个或多个心脏信号矢量检测一个或多个心脏信号矢量的改变。 使用一个或多个心脏信号载体来区分心律失常。

公开(公告)号：US20080114410A1

公开(公告)日：2008-05-15

申请号：US12016830

申请日：2008-01-18

申请人： Jiang Ding ,  Julio Spinelli ,  Yinghong Yu ,  Jeffrey Stahmann

发明人： Jiang Ding ,  Julio Spinelli ,  Yinghong Yu ,  Jeffrey Stahmann

IPC分类号： A61N1/365

CPC分类号： A61N1/3627 ,  A61B5/053 ,  A61N1/36521 ,  A61N1/3682 ,  A61N1/3684

摘要： This document discusses, among other things, systems, devices, and methods measure an impedance and, in response, adjust an atrioventricular (AV) delay or other cardiac resynchronization therapy (CRT) parameter that synchronizes left and right ventricular contractions. A first example uses parameterizes a first ventricular volume against a second ventricular volume during a cardiac cycle, using a loop area to create a synchronization fraction (SF). The CRT parameter is adjusted in closed-loop fashion to increase the SF. A second example measures a septal-freewall phase difference (PD), and adjusts a CRT parameter to decrease the PD. A third example measures a peak-to-peak volume or maximum rate of change in ventricular volume, and adjusts a CRT parameter to increase the peak-to-peak volume or maximum rate of change in the ventricular volume.

摘要翻译： 本文件还讨论了系统，设备和方法测量阻抗，并作为响应调整房室（AV）延迟或同步左心室收缩和右心室收缩的其他心脏再同步治疗（CRT）参数。 第一个例子是使用循环区域创建同步分数（SF），在心动周期中使用第一心室容积对第二心室容积进行参数化。 CRT参数以闭环方式调整以增加SF。 第二个例子是测量隔层相位差（PD），并调整CRT参数以减少PD。 第三个例子测量心室容积的峰 - 峰体积或最大变化率，并调整CRT参数以增加心室容积的峰 - 峰体积或最大变化率。

公开(公告)号：US20060259086A1

公开(公告)日：2006-11-16

申请号：US11126490

申请日：2005-05-11

申请人： Yinghong Yu ,  Jiang Ding ,  Jeffrey Stahmann

发明人： Yinghong Yu ,  Jiang Ding ,  Jeffrey Stahmann

IPC分类号： A61N1/362

CPC分类号： A61N1/3682 ,  A61N1/3627 ,  A61N1/3706

摘要： Systems and methods to optimize atrioventricular delay during sensing or pacing of the atrium and for a plurality of sensed rates or pacing rates. In one example, a paced atrioventricular delay is calculated using a sensed atrioventricular interval and a paced atrioventricular interval. In another example, a plurality of paced atrioventricular delays for different pacing rates can be calculated. In another example embodiment, a plurality of sensed atrioventricular delays for different sensing rates can be calculated. Combinations of the various systems and methods are also possible.

摘要翻译： 在心房的感测或起搏期间以及多个感测速率或起搏速率下优化房室延迟的系统和方法。 在一个示例中，使用感测的房室间隔和起搏房室间隔来计算起搏房室延迟。 在另一个示例中，可以计算用于不同起搏速率的多个起搏房室延迟。 在另一示例性实施例中，可以计算用于不同感测速率的多个感测的房室延迟。 各种系统和方法的组合也是可能的。

公开(公告)号：US20060271121A1

公开(公告)日：2006-11-30

申请号：US11136894

申请日：2005-05-25

申请人： Jiang Ding ,  Julio Spinelli ,  Yinghong Yu ,  Jeffrey Stahmann

发明人： Jiang Ding ,  Julio Spinelli ,  Yinghong Yu ,  Jeffrey Stahmann

IPC分类号： A61N1/368

CPC分类号： A61N1/3627 ,  A61B5/053 ,  A61N1/36521 ,  A61N1/3682 ,  A61N1/3684

摘要： This document discusses, among other things, systems, devices, and methods measure an impedance and, in response, adjust an atrioventricular (AV) delay or other cardiac resynchronization therapy (CRT) parameter that synchronizes left and right ventricular contractions. A first example uses parameterizes a first ventricular volume against a second ventricular volume during a cardiac cycle, using a loop area to create a synchronization fraction (SF). The CRT parameter is adjusted in closed-loop fashion to increase the SF. A second example measures a septal-freewall phase difference (PD), and adjusts a CRT parameter to decrease the PD. A third example measures a peak-to-peak volume or maximum rate of change in ventricular volume, and adjusts a CRT parameter to increase the peak-to-peak volume or maximum rate of change in the ventricular volume.