公开(公告)号：US20110071588A1

公开(公告)日：2011-03-24

申请号：US12955218

申请日：2010-11-29

申请人： Jiang Ding ,  Yinghong Yu ,  Andrew P. Kramer ,  Julio Spinelli

发明人： Jiang Ding ,  Yinghong Yu ,  Andrew P. Kramer ,  Julio Spinelli

IPC分类号： A61N1/365

CPC分类号： E21B17/01 ,  A61N1/3627 ,  A61N1/3682 ,  E21B43/36

摘要： A pacing system for providing optimal hemodynamic cardiac function for parameters such as contractility (peak left ventricle pressure change during systole or LV+dp/dt), or stroke volume (aortic pulse pressure) using system for calculating atrio-ventricular delays for optimal timing of a ventricular pacing pulse. The system providing an option for near optimal pacing of multiple hemodynamic parameters. The system deriving the proper timing using electrical or mechanical events having a predictable relationship with an optimal ventricular pacing timing signal.

摘要翻译： 一种起搏系统，用于为诸如收缩性（收缩期峰值左心室压力变化或LV + dp / dt）之间的参数或行程体积（主动脉脉压）提供最佳血液动力学心脏功能，使用用于计算心室延迟的系统以获得最佳时机 心室起搏脉搏。 该系统为多个血液动力学参数的近似最佳起搏提供了选择。 该系统使用与最佳心室起搏定时信号具有可预测关系的电或机械事件导出适当的定时。

公开(公告)号：US20080114410A1

公开(公告)日：2008-05-15

申请号：US12016830

申请日：2008-01-18

申请人： Jiang Ding ,  Julio Spinelli ,  Yinghong Yu ,  Jeffrey Stahmann

发明人： Jiang Ding ,  Julio Spinelli ,  Yinghong Yu ,  Jeffrey Stahmann

IPC分类号： A61N1/365

CPC分类号： A61N1/3627 ,  A61B5/053 ,  A61N1/36521 ,  A61N1/3682 ,  A61N1/3684

摘要： This document discusses, among other things, systems, devices, and methods measure an impedance and, in response, adjust an atrioventricular (AV) delay or other cardiac resynchronization therapy (CRT) parameter that synchronizes left and right ventricular contractions. A first example uses parameterizes a first ventricular volume against a second ventricular volume during a cardiac cycle, using a loop area to create a synchronization fraction (SF). The CRT parameter is adjusted in closed-loop fashion to increase the SF. A second example measures a septal-freewall phase difference (PD), and adjusts a CRT parameter to decrease the PD. A third example measures a peak-to-peak volume or maximum rate of change in ventricular volume, and adjusts a CRT parameter to increase the peak-to-peak volume or maximum rate of change in the ventricular volume.

摘要翻译： 本文件还讨论了系统，设备和方法测量阻抗，并作为响应调整房室（AV）延迟或同步左心室收缩和右心室收缩的其他心脏再同步治疗（CRT）参数。 第一个例子是使用循环区域创建同步分数（SF），在心动周期中使用第一心室容积对第二心室容积进行参数化。 CRT参数以闭环方式调整以增加SF。 第二个例子是测量隔层相位差（PD），并调整CRT参数以减少PD。 第三个例子测量心室容积的峰 - 峰体积或最大变化率，并调整CRT参数以增加心室容积的峰 - 峰体积或最大变化率。

公开(公告)号：US07346393B2

公开(公告)日：2008-03-18

申请号：US10460975

申请日：2003-06-12

申请人： Julio Spinelli ,  Qingsheng Zhu ,  Bruce H. Kenknight ,  Yinghong Yu ,  Jiang Ding

发明人： Julio Spinelli ,  Qingsheng Zhu ,  Bruce H. Kenknight ,  Yinghong Yu ,  Jiang Ding

IPC分类号： A61N1/36

CPC分类号： A61N1/3627

摘要： A cardiac rhythm management system for providing a plurality of therapy modalities. For example, the system may include a cardiac resynchronization therapy module for providing cardiac resynchronization therapy and a pacemaker module for providing bradycardia therapy, as well as a selector module coupled to the cardiac resynchronization therapy module and the bradycardia module. The selector module may select an operating mode from among a plurality of operating modes including the cardiac resynchronization therapy module and the pacemaker module. Various manual and automatic methods may be used to select the operating mode. In addition, a reversion management system may be included to assist the cardiac rhythm management system to recover in case of a disruption to the system.

摘要翻译： 一种用于提供多种治疗方式的心律管理系统。 例如，该系统可以包括用于提供心脏再同步治疗的心脏再同步治疗模块和用于提供心动过缓治疗的起搏器模块，以及耦合到心脏再同步治疗模块和心动过缓模块的选择器模块。 选择器模块可以从包括心脏再同步治疗模块和起搏器模块的多个操作模式中选择操作模式。 可以使用各种手动和自动方法来选择操作模式。 此外，还可以包括回归管理系统以帮助心律管理系统在系统中断的情况下恢复。

公开(公告)号：US20070021789A1

公开(公告)日：2007-01-25

申请号：US11458286

申请日：2006-07-18

申请人： Joseph Pastore ,  Julio Spinelli ,  Frits Prinzen ,  Richard Cornelussen ,  Ward Vanagt

发明人： Joseph Pastore ,  Julio Spinelli ,  Frits Prinzen ,  Richard Cornelussen ,  Ward Vanagt

IPC分类号： A61N1/00

CPC分类号： A61N1/3622

摘要： A device and method for delivering electrical stimulation to the heart in a manner which provides a protective effect is disclosed. The protective effect is produced by configuring a cardiac pacing device to intermittently switch from a normal operating mode to a stress augmentation mode in which the spatial pattern of depolarization is varied to thereby subject a particular region or regions of the ventricular myocardium to increased mechanical stress.

摘要翻译： 公开了以提供保护作用的方式向心脏递送电刺激的装置和方法。 通过将心脏起搏装置配置为间歇地从正常操作模式切换到应力增强模式，其中去极化的空间模式改变从而使心室心肌的特定区域或区域增加机械应力，从而产生保护作用。

公开(公告)号：US20060253161A1

公开(公告)日：2006-11-09

申请号：US11124791

申请日：2005-05-09

申请人： Imad Libbus ,  Andrew Kramer ,  Julio Spinelli

发明人： Imad Libbus ,  Andrew Kramer ,  Julio Spinelli

IPC分类号： A61N1/365

CPC分类号： A61N1/36057 ,  A61N1/36114 ,  A61N1/36139 ,  A61N1/3621 ,  A61N1/3627 ,  A61N1/36585

摘要： A neural stimulation system senses autonomic activities and applies neural stimulation to sympathetic and parasympathetic nerves to control autonomic balance. The neural stimulation system is capable of delivering neural stimulation pulses for sympathetic excitation, sympathetic inhibition, parasympathetic excitation, and parasympathetic inhibition.

公开(公告)号：US20060052830A1

公开(公告)日：2006-03-09

申请号：US11268284

申请日：2005-11-03

申请人： Julio Spinelli ,  Qingsheng Zhu ,  Jeffrey Stahmann ,  Andrew Kramer

发明人： Julio Spinelli ,  Qingsheng Zhu ,  Jeffrey Stahmann ,  Andrew Kramer

IPC分类号： A61N1/39

CPC分类号： A61N1/3622 ,  A61N1/3684

摘要： A system, method, or device classifies an arrhythmia according to the temporal order in which a depolarization wave associated with a particular heart contraction is received at a plurality of electrodes. One or more antiarrhythmia therapies is mapped to each arrhythmia classification. When a particularly classified arrhythmia is detected, the correspondingly mapped therapy list is selected and an appropriate antiarrhythmia therapy delivered. In one example, the particular therapy delivered in response to an arrhythmia depends at least in part on its historical success in treating arrhythmias of that classification.

公开(公告)号：US20050288720A1

公开(公告)日：2005-12-29

申请号：US10862011

申请日：2004-06-04

申请人： Jeffrey Ross ,  Julio Spinelli ,  Rodney Salo

发明人： Jeffrey Ross ,  Julio Spinelli ,  Rodney Salo

IPC分类号： A61N1/362

CPC分类号： A61N1/3627

摘要： A cardiac rhythm management device is configured to deliver pre-excitation pacing to one or more sites in proximity to an infarcted region of the ventricular myocardium. The pre-excitation pacing in conjunction with counterpulsation therapy serves to either prevent or minimize post-infarct remodeling.

摘要翻译： 心律管理装置被配置为将预激励起搏递送到心室心肌梗塞区域附近的一个或多个部位。 预激励起搏结合反搏疗法可预防或最小化梗死后重塑。

公开(公告)号：US20050283099A1

公开(公告)日：2005-12-22

申请号：US11203756

申请日：2005-08-15

申请人： Qingsheng Zhu ,  Avram Scheiner ,  Julio Spinelli

发明人： Qingsheng Zhu ,  Avram Scheiner ,  Julio Spinelli

IPC分类号： A61N1/05 ,  A61N1/32 ,  A61H1/02

CPC分类号： A61N1/326 ,  A61N1/0587

摘要： A method and device for preventing plaque build-up in a coronary artery includes providing an electrical field generating device, and generating an electrical field in the coronary artery to prevent plaque build-up in the coronary artery. The method further includes sensing the heart rhythm and generating the electrical field after a depolarization wave in the heart. The electrical field is generated by circuitry, in one embodiment implanted circuitry, connected to leads which are epicardially or intracardially positioned on the heart.

摘要翻译： 用于防止冠状动脉斑块积聚的方法和装置包括提供电场产生装置，并且在冠状动脉中产生电场以防止冠状动脉中的斑块积聚。 该方法还包括感测心脏节律并在心脏中去极化波之后产生电场。 电场由电路产生，在一个实施例中，植入电路连接到心外膜或心内置于心脏上的引线。

公开(公告)号：US06766189B2

公开(公告)日：2004-07-20

申请号：US09822790

申请日：2001-03-30

申请人： Yinghong Yu ,  Jiang Ding ,  Julio Spinelli ,  Angelo Auricchio

发明人： Yinghong Yu ,  Jiang Ding ,  Julio Spinelli ,  Angelo Auricchio

IPC分类号： A61B106

CPC分类号： A61N1/3627 ,  A61N1/3682

摘要： A method and apparatus for predicting acute response to cardiac resynchronization therapy is disclosed. The method can comprise measuring a first interval during an intrinsic systolic cycle and measuring a second interval during a stimulated systolic cycle. The acute response can be predicted by comparing the percent change in duration between the first interval and the second interval against a pre-determined threshold value. The first and second time intervals can be measured using, for example, a surface ECG or, alternatively, an intracardiac electrogram. In one embodiment, the first interval can be the duration of an intrinsic QRS complex measured during a non-stimulated systolic cycle. Similarly, the second interval can be the duration of a stimulated QRS complex measured during a stimulated systolic cycle.

公开(公告)号：US06280389B1

公开(公告)日：2001-08-28

申请号：US09439228

申请日：1999-11-12

申请人： Jiang Ding ,  Yinghong Yu ,  Julio Spinelli

发明人： Jiang Ding ,  Yinghong Yu ,  Julio Spinelli

IPC分类号： A61B5021

CPC分类号： A61N1/365 ,  A61N1/3622 ,  A61N1/3627 ,  A61N1/37

摘要： A method and apparatus for determining whether a patient with congestive heart failure (CHF) will benefit from pacing therapy through the use of an implantable cardiac rhythm management device. A patient's right ventricular and left ventricular pressures are measured, and the patient's PP_Area is calculated for each normal heartbeat that occurs during the testing period. Depending upon the value of the patient's mean PP_Area, it can be determined whether the patient will or will not respond well acutely to pacing therapy. A mean PP_Area value of greater than or equal to a predetermined threshold, which is about 0.3, indicates that the patient is a responder to pacing therapy, while a value of less than the predetermined threshold of about 0.3 indicates that the patient is a non-responder.

摘要翻译： 一种用于确定患有充血性心力衰竭（CHF）的患者是否将通过使用植入式心律管理装置从起搏治疗中受益的方法和装置。 测量患者的右心室和左心室压力，并计算在测试期间发生的每个正常心跳的患者的PP_Area。 根据患者平均PP_Area的价值，可以确定患者是否会或不会对起搏治疗产生很好的反应。 大于或等于预定阈值（约0.3）的平均PP_Area值表示患者是起搏治疗的应答​​者，而小于约0.3的预定阈值的值表示患者是非 - 响应者。