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公开(公告)号：US20100035947A1
公开(公告)日：2010-02-11
申请号：US12450699
申请日：2008-04-11
IPC分类号： A61K31/424 , C07D498/04
CPC分类号： C07D309/28 , A61K31/351 , C07C41/60 , C07D231/14 , C07D407/06 , C07D498/04 , C07C43/32
摘要： A method for manufacturing neuraminic acid derivatives is provided, also synthetic intermediates of the neuraminic acid derivatives and methods for their manufacture, and neuraminic acid derivatives having high purity.[Means for Solution]A synthetic intermediate compound represented by the formula (7) is provided: [wherein R3 represents alkyl; R4 and R5 each represents H, alkyl, phenyl, or together represent tetramethylene, pentamethylene, oxo].
摘要翻译： 还提供了制备神经氨酸衍生物的方法，还涉及神经氨酸衍生物的合成中间体及其制备方法和具有高纯度的神经氨酸衍生物。 [解决方案]提供由式（7）表示的合成中间体化合物：[其中R 3表示烷基; R4和R5各自表示H，烷基，苯基，或一起表示四亚甲基，五亚甲基，氧代〕。
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公开(公告)号：US07064209B2
公开(公告)日：2006-06-20
申请号：US10495268
申请日：2002-11-14
IPC分类号： C07D215/14
CPC分类号： C07D215/14
摘要： A novel process for producing an optically active (E)-7-[2-cyclopropyl-4-(4-fluorophenyl quinolin-3-yl]-5-hydroxy-3-oxohept-6-enoic acid ester of formula (III) which is important as an intermediate for synthesizing medicines, comprises reacting 1,3-bis(trimethylsilyloxy)-1-alkoxybuta-1,3-diene of formula (I) with (E)-3-[2-cyclopropyl-4-(4-fluorophenyl)-quinolin-3-yl]-prop-2-en-1-al of formula (II) in the presence of an optically active binaphthol-titanium complex obtained from 1,1′-bi-2-naphthol with titanium tetraisopropoxide, a metal salt and an amine, and then subjecting the reaction product to desilylation
摘要翻译： 制备式（III）的光学活性（E）-7- [2-环丙基-4-（4-氟苯基喹啉-3-基）-5-羟基-3-氧代庚-6-烯酸酯的新方法， 其作为合成药物的中间体是重要的，包括使式（I）的1,3-双（三甲基甲硅烷氧基）-1-烷氧基丁-1,3-二烯与（E）-3- [2-环丙基-4-（ 4-氟苯基） - 喹啉-3-基] - 丙-2-烯-1-醇在由1,1'-双-2-萘酚与 四异丙醇钛，金属盐和胺，然后使反应产物脱甲硅烷基化
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公开(公告)号：US20130107588A1
公开(公告)日：2013-05-02
申请号：US13558346
申请日：2012-07-26
申请人： Taisuke KATAYAMA , Ryuji Suenaga , Kazuhiro Umeo , Eiji Yamamoto
发明人： Taisuke KATAYAMA , Ryuji Suenaga , Kazuhiro Umeo , Eiji Yamamoto
IPC分类号： H02M5/458
CPC分类号： H02M7/49 , H02J3/12 , H02M2007/4835
摘要： A series-connected multi-level power conversion device according to an aspect of embodiments includes a multi-winding transformer and a power conversion unit. The multi-winding transformer has a relationship that n secondary windings respectively connected to n single-phase power converters in the same output phase have a voltage phase difference of 60/n degrees and a relationship that the m secondary windings respectively connected to the m single-phase power converters corresponding to the m output phases have a voltage phase difference of 60/m degrees.
摘要翻译： 根据实施例的一个方面的串联多电平电力转换装置包括多绕组变压器和电力转换单元。 多绕组变压器具有在相同输出相中分别连接到n个单相功率转换器的n个次级绕组具有60 / n度的电压相位差以及分别连接到m单个的m个次级绕组的关系的关系 对应于m个输出相的相电力转换器具有60 / m度的电压相位差。
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公开(公告)号：US20050054853A1
公开(公告)日：2005-03-10
申请号：US10495268
申请日：2002-11-14
IPC分类号： C07D215/14 , C07D215/00
CPC分类号： C07D215/14
摘要： A novel process for producing an optically active (E)-7-[2-cyclopropyl-4-(4-fluorophenyl quinolin-3-yl]-5-hydroxy-3-oxohept-enoic acid ester of formula (III) which is important as an intermediate for synthesizing medicines, comprises reacting 1,3-bis(trimethylsilyloxy)-1-alkoxybuta-1,3-diene of formula (I) with (E)-3-[2-cyclopropyl-4-(fluorophenyl)quinolin-3-yl]-prop-2-en-1-al of formula (II) in the presence of an optically active binaphthol-titanium complex obtained from 1,1′-bi-2-naphthol with titanium tetraisopropoxide, a metal salt and an amine, and then subjecting the reaction product to desilylation.
摘要翻译： 制备式（III）的光学活性（E）-7- [2-环丙基-4-（4-氟苯基喹啉-3-基）-5-羟基-3-氧代庚酸 - 烯酸酯的新方法，其为 作为合成药物的中间体是重要的，包括使式（I）的1,3-双（三甲基甲硅烷氧基）-1-烷氧基丁-1,3-二烯与（E）-3- [2-环丙基-4-（氟苯基） 喹啉-3-基] - 丙-2-烯-1-醇在由1,1'-双-2-萘酚与四异丙氧基钛得到的光学活性联萘酚钛络合物存在下，金属 盐和胺，然后使反应产物脱甲硅烷基化。
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公开(公告)号：US08923024B2
公开(公告)日：2014-12-30
申请号：US13558346
申请日：2012-07-26
申请人： Taisuke Katayama , Ryuji Suenaga , Kazuhiro Umeo , Eiji Yamamoto
发明人： Taisuke Katayama , Ryuji Suenaga , Kazuhiro Umeo , Eiji Yamamoto
CPC分类号： H02M7/49 , H02J3/12 , H02M2007/4835
摘要： A series-connected multi-level power conversion device according to an aspect of embodiments includes a multi-winding transformer and a power conversion unit. The multi-winding transformer has a relationship that n secondary windings respectively connected to n single-phase power converters in the same output phase have a voltage phase difference of 60/n degrees and a relationship that the m secondary windings respectively connected to the m single-phase power converters corresponding to the m output phases have a voltage phase difference of 60/m degrees.
摘要翻译： 根据实施例的一个方面的串联多电平电力转换装置包括多绕组变压器和电力转换单元。 多绕组变压器具有在相同输出相中分别连接到n个单相功率转换器的n个次级绕组具有60 / n度的电压相位差以及分别连接到m单个的m个次级绕组的关系的关系 对应于m个输出相的相电力转换器具有60 / m度的电压相位差。
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