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公开(公告)号:US20180346425A1
公开(公告)日:2018-12-06
申请号:US16053879
申请日:2018-08-03
IPC分类号: C07D215/14
CPC分类号: C07D215/14 , C07B2200/13
摘要: The present invention is directed to new crystalline forms of Pitavastatin hemicalcium salt, referred to hereinafter as polymorphic Forms A, B, C, D, E and F, as well as the amorphous form. Furthermore, the present invention is directed to processes for the preparation of these crystalline forms and the amorphous form and pharmaceutical compositions comprising these crystalline forms or the amorphous forms.
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2.
公开(公告)号:US10034879B2
公开(公告)日:2018-07-31
申请号:US15852406
申请日:2017-12-22
发明人: Brian Metcalf , Chihyuan Chuang
IPC分类号: C07D401/00 , A61K31/4985 , C07D215/14 , C07D471/04 , C07D487/04 , C07D213/80 , C07D231/56 , C07D401/04 , C07D257/04 , C07D211/62 , C07D213/30 , C07C69/76 , C07C65/30 , A61K31/192 , A61K31/235 , A61K31/41 , A61K31/416 , A61K31/437 , A61K31/4406 , A61K31/4439 , A61K31/445 , A61K31/47
CPC分类号: A61K31/4985 , A61K31/192 , A61K31/235 , A61K31/41 , A61K31/416 , A61K31/437 , A61K31/4406 , A61K31/4439 , A61K31/445 , A61K31/47 , C07C65/30 , C07C69/76 , C07D211/62 , C07D213/30 , C07D213/80 , C07D215/14 , C07D231/56 , C07D257/04 , C07D401/04 , C07D471/04 , C07D487/04
摘要: Provided are substituted benzaldehydes and derivatives thereof that act as allosteric modulators of hemoglobin, methods and intermediates for their preparation, pharmaceutical compositions comprising the modulators, and methods for their use in treating disorders mediate by hemoglobin and disorders that would benefit from increased tissue oxygenation.
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公开(公告)号:US09981901B2
公开(公告)日:2018-05-29
申请号:US15356292
申请日:2016-11-18
IPC分类号: C07C235/42 , A61K31/166 , C07C65/21 , C07C65/26 , C07C65/11 , C07C233/65
CPC分类号: C07C65/21 , A61K31/11 , A61K31/135 , A61K31/166 , A61K31/192 , A61K31/357 , A61K31/381 , A61K31/505 , A61K31/5375 , A61K31/5377 , C07C47/55 , C07C47/565 , C07C47/575 , C07C65/11 , C07C65/26 , C07C65/30 , C07C205/44 , C07C205/61 , C07C223/02 , C07C233/65 , C07C235/42 , C07C235/84 , C07C251/24 , C07C317/24 , C07C321/04 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D213/48 , C07D213/64 , C07D213/69 , C07D213/74 , C07D215/14 , C07D217/16 , C07D231/12 , C07D235/08 , C07D239/26 , C07D239/54 , C07D241/18 , C07D249/18 , C07D261/08 , C07D277/34 , C07D295/125 , C07D295/15 , C07D295/192 , C07D307/80 , C07D317/54 , C07D319/08 , C07D319/18 , C07D321/10 , C07D333/22 , C07D333/58 , C07D401/12 , C07D403/12 , C07D417/10 , Y02A50/389 , Y02A50/393
摘要: Compounds which directly inhibit IRE-1α activity in vitro, prodrugs, and pharmaceutically acceptable salts thereof. Such compounds and prodrugs are useful for treating diseases associated with the unfolded protein response and can be used as single agents or in combination therapies.
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公开(公告)号:US09969691B2
公开(公告)日:2018-05-15
申请号:US15324972
申请日:2015-07-08
申请人: LUPIN LIMITED
IPC分类号: C07D215/14
CPC分类号: C07D215/14 , C07B2200/13
摘要: The present invention is directed to polymorphic forms of Pitavastatin sodium and processes for preparation of the same.
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5.
公开(公告)号:US20180117040A1
公开(公告)日:2018-05-03
申请号:US15852406
申请日:2017-12-22
发明人: Brian Metcalf , Chihyuan Chuang
IPC分类号: A61K31/4985 , C07C65/30 , C07D215/14 , A61K31/235 , A61K31/41 , A61K31/416 , A61K31/437 , A61K31/4439 , A61K31/445 , A61K31/47 , A61K31/192 , C07D213/30 , C07C69/76 , C07D471/04 , C07D211/62 , C07D257/04 , C07D401/04 , C07D231/56 , C07D213/80 , C07D487/04 , A61K31/4406
CPC分类号: A61K31/4985 , A61K31/192 , A61K31/235 , A61K31/41 , A61K31/416 , A61K31/437 , A61K31/4406 , A61K31/4439 , A61K31/445 , A61K31/47 , C07C65/30 , C07C69/76 , C07D211/62 , C07D213/30 , C07D213/80 , C07D215/14 , C07D231/56 , C07D257/04 , C07D401/04 , C07D471/04 , C07D487/04
摘要: Provided are substituted benzaldehydes and derivatives thereof that act as allosteric modulators of hemoglobin, methods and intermediates for their preparation, pharmaceutical compositions comprising the modulators, and methods for their use in treating disorders mediate by hemoglobin and disorders that would benefit from increased tissue oxygenation.
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6.
公开(公告)号:US20180029990A1
公开(公告)日:2018-02-01
申请号:US15785193
申请日:2017-10-16
IPC分类号: C07D217/12 , C07D209/12 , A23L33/10 , C07D215/14
CPC分类号: C07D217/12 , A23L33/10 , C07D209/12 , C07D215/14
摘要: Bicyclic compounds for decreasing the expression of bacterial virulence factors thereby preventing, mitigating, or treating bacterial infection are provided.
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公开(公告)号:US20180009757A1
公开(公告)日:2018-01-11
申请号:US15661143
申请日:2017-07-27
申请人: Institut National de la Sante et de la Recherche Medicale (INSERM) , Universite Paul Sabatier Toulouse III , Universite Paris-Sud , Universite d'Orleans
发明人: Frank Lezoualc'h , Rodolphe Fischmeister , Malik Bisserier , Pascal Bouyssou , Jean-Paul Blondeau , Delphine Courilleau
IPC分类号: C07D215/14 , A61K31/47 , C07D215/08 , C07D215/18
CPC分类号: C07D215/14 , A61K31/47 , C07D215/08 , C07D215/18
摘要: The invention relates to tetrahydroquinoline derivatives and their use in the treatment and/or the prevention of a disease wherein the Epac protein is involved, such as inflammation, cancer, vascular diseases, kidney diseases, cognitive disorders and cardiac diseases.
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公开(公告)号:US09850225B2
公开(公告)日:2017-12-26
申请号:US14681772
申请日:2015-04-08
发明人: Louis S. Chupak , Min Ding , Scott W. Martin , Xiaofan Zheng , Piyasena Hewawasam , Timothy P. Connolly , Ningning Xu , Kap-Sun Yeung , Juliang Zhu , David R. Langley , Paul Michael Scola
IPC分类号: C07D319/18 , A61K31/357 , C07D405/12 , A61K31/453 , C07D405/14 , A61K31/4545 , C07D217/16 , A61K31/472 , C07D413/12 , A61K31/5377 , C07D417/12 , A61K31/541 , A61K31/496 , A61K45/06 , C07C255/54 , C07D215/14 , C07D215/18 , C07D231/56 , C07D405/04 , C07D239/26 , C07D261/08 , C07D271/06 , C07D207/26 , C07D207/335 , C07D213/30 , C07C271/28 , C07C317/22 , C07C233/36 , C07C235/42 , C07C255/13 , A61K31/165 , A61K31/277 , A61K31/40 , A61K31/4015 , A61K31/416 , A61K31/4178 , A61K31/4245 , A61K31/427 , A61K31/4433 , A61K31/47 , A61K31/505
CPC分类号: C07D319/18 , A61K31/165 , A61K31/277 , A61K31/357 , A61K31/40 , A61K31/4015 , A61K31/416 , A61K31/4178 , A61K31/4245 , A61K31/427 , A61K31/4433 , A61K31/453 , A61K31/4545 , A61K31/47 , A61K31/472 , A61K31/496 , A61K31/505 , A61K31/5377 , A61K31/541 , A61K45/06 , C07C233/36 , C07C235/42 , C07C255/13 , C07C255/54 , C07C271/28 , C07C317/22 , C07D207/26 , C07D207/335 , C07D213/30 , C07D215/14 , C07D215/18 , C07D217/16 , C07D231/56 , C07D239/26 , C07D261/08 , C07D271/06 , C07D405/04 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , Y02A50/463 , A61K2300/00
摘要: The present disclosure generally relates to compounds useful as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and methods of their use. The disclosure further pertains to pharmaceutical compositions comprising at least one compound according to the disclosure that are useful for the treatment of various diseases, including cancer and infectious diseases.
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公开(公告)号:US09815797B2
公开(公告)日:2017-11-14
申请号:US15101283
申请日:2014-12-08
申请人: UCB BIOPHARMA SPRL
发明人: Rikki Peter Alexander , Gregory Foulkes , Martin Clive Hutchings , Victoria Elizabeth Jackson , Boris Kroeplien , James Thomas Reuberson , Sarah Margaret Rook , Zhaoning Zhu
IPC分类号: C07D239/74 , A61K31/47 , A61K31/472 , A61K31/498 , A61K31/506 , A61K31/517 , C07D215/14 , C07D237/28 , A61K31/502 , C07D215/06 , C07D237/32 , C07D241/44 , A61K45/06 , C07D217/16 , C07D241/42 , C07D403/04
CPC分类号: C07D239/74 , A61K31/47 , A61K31/472 , A61K31/498 , A61K31/502 , A61K31/506 , A61K31/517 , A61K45/06 , C07D215/06 , C07D215/14 , C07D217/16 , C07D237/28 , C07D237/32 , C07D241/42 , C07D241/44 , C07D403/04 , A61K2300/00
摘要: A series of substituted heteroaromatic compounds containing two fused six-membered rings, tivity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
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公开(公告)号:US09815788B2
公开(公告)日:2017-11-14
申请号:US15194745
申请日:2016-06-28
申请人: University College Dublin National University of Ireland, Dublin , The Provost, Fellows, Foundation Scholars, and the other members of Board, of the College of the Holy
发明人: Breandan Noel Kennedy , Alison Reynolds , Claire Kilty , Jacintha O'Sullivan , Andrew Douglas Baxter
IPC分类号: C07D215/14 , A61K31/47 , A61K9/00 , A61K31/4725
CPC分类号: C07D215/14 , A61K9/0014 , A61K9/0019 , A61K9/0048 , A61K31/47 , A61K31/4725
摘要: (E)-2-(2-Quinolin-2-yl-propenyl)-phenol, 2-Quinolin-2-yl-ylethynyl-phenol and salts thereof are useful as medicaments, especially for treatment of an angiogenesis-related disease or disorder.
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